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Workgroup Chairs:

Professor Cynthia Bulik, Professor Gerome Breen, and Dr Laura Huckins

If you have questions concerning the projects this workgroup is undertaking, please contact the work group chair(s).

Core Analytical Group Directors: 

Gerome Breen, Melissa Munn-Chernoff, Jet Termorshuizen, and Jonathan Coleman 

Outreach Liaison:

Position currently vacant. If interested Cynthia Bulik.

If you have questions concerning this web page or our social media accounts, and/or you have resources that you would like to share with the public, please contact the work group outreach liaison(s).

Data Access Committee (DAC) Representative:

Karen Mitchell

If you have any questions about accessing PGC ED data, please contact the DAC representative.

ED Data Access Portal

About Us

The eating disorders workgroup (PGC-ED) has been a part of the PGC since 2013. During that time, our membership has grown to include investigators from over 20 countries spanning North America, Europe, Asia, and Australasia. Our group focuses on the study of anorexia nervosa, bulimia nervosa, binge-eating disorder, avoidant/restrictive food intake disorder (ARFID), and other eating disorders.

Prof. Cynthia Bulik (University of North Carolina at Chapel Hill and Karolinska Institutet, Stockholm, Sweden), Prof. Gerome Breen (King’s College London, UK), and Asst. Prof. Laura Huckins (Icahn School of Medicine at Mount Sinai) chair our group. Our interdisciplinary membership includes graduate and postdoctoral trainees from a range of disciplines as well as distinguished faculty in psychiatry, psychology, biostatistics, genetics, nutrition, nursing, and related fields. We are currently working toward uniting researchers and clinicians globally to create the largest collection of DNA from individuals with eating disorders in the world. Our current goals are to rapidly increase sample size for our anorexia nervosa studies and to expand our scope to complete GWAS for bulimia nervosa, binge-eating disorder, and ARFID.

Members of the workgroup stay connected through regular conference calls on the first Thursday of every month and via the PGC-ED listserv. Please contact Andri Savva if interested in learning more about the conference calls. If you are a member of the PGC-ED and have questions about a specific analysis or if you are interested in joining an ongoing approved secondary analysis project, please contact the investigator leading that project.

We are an open and welcoming group. If you have samples from patients or individuals with eating disorders and would like to join the group and have your samples genotyped, please contact us. If you are interested in hearing more, please contact either Cynthia Bulik, Gerome Breen, or Laura Huckins.

Becoming A PGC-ED Member

PGC-ED Welcome packet 

Information for new sites about how to become a contributing member of the PGC-ED.

Publications

Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V, Bulik-Sullivan B, Ripke S; Eating Disorders Working Group of the Psychiatric Genomics Consortium, Thornton L, Hinney A, Daly M, Sullivan PF, Zeggini E, Breen G, Bulik CM. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry 174, 850-858 (2017). doi: 10.1176/appi.ajp.2017.16121402 PMID: 28494655; PMCID: PMC5581217.

Watson, H.J., Yilmaz, Z., Thornton, L.M. et al. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosaNat Genet 51, 1207–1214 (2019). https://doi.org/10.1038/s41588-019-0439-2

Hübel, C., Gaspar, H.A., Coleman, J.R.I. et al. Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependentNat Commun 10, 5765 (2019). https://doi.org/10.1038/s41467-019-13544-0

Hübel C, Gaspar HA, Coleman JRI, Finucane H, Purves KL, Hanscombe KB, Prokopenko I; MAGIC investigators, Graff M, Ngwa JS, Workalemahu T; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, O’Reilly PF, Bulik CM, Breen G. Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. Am J Med Genet B Neuropsychiatr Genet 180, 428-438 (2019). doi: 10.1002/ajmg.b.32709. PMID: 30593698; PMCID: PMC6751355.

Yao S, Kuja-Halkola R, Martin J, Lu Y, Lichtenstein P, Norring C, Birgegård A, Yilmaz Z, Hübel C, Watson H, Baker J, Almqvist C; Eating Disorders Working Group of the Psychiatric Genomics Consortium, Thornton LM, Magnusson PK, Bulik CM, Larsson H. Associations between attention-deficit/hyperactivity disorder and various eating disorders: A Swedish nationwide population study using multiple genetically informative approaches. Biol Psychiatry 86,577-586 (2019). doi: 10.1016/j.biopsych.2019.04.036. PMID: 31301758; PMCID: PMC6776821.

Munn‐Chernoff, MA, Johnson, EC, Chou, Y‐L, et al. Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studiesAddiction Biology. 2020; e12880.  https://doi.org/10.1111/adb.12880

Yilmaz Z, Halvorsen M, Bryois J, Yu D, Thornton LM, Zerwas S, Micali N, Moessner R, Burton CL, Zai G, Erdman L, Kas MJ, Arnold PD, Davis LK, Knowles JA, Breen G, Scharf JM, Nestadt G, Mathews CA, Bulik CM, Mattheisen M, Crowley JJ; Eating Disorders Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive–Compulsive Disorder Working Group of the Psychiatric Genomics Consortium. Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder. Mol Psychiatry 25, 2036-2046 (2020). doi: 10.1038/s41380-018-0115-4. PMID: 30087453; PMCID: PMC6367065.

Funders

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