Obsessive Compulsive Disorder and Tourette Syndrome (OCD/TS)

Workgroup Chairs: Jeremiah Scharf and Manuel Mattheisen

OCD Data Access Portal TS Data Access Portal

 

The OCD/TS workgroup has been a part of the PGC since 2013. During that time, our membership has grown to include nearly 100 investigators from 17 countries. Our group focuses on the study of chronic tic and obsessive compulsive spectrum disorders.

Dr. Carol Mathews from the University of Florida chairs our group. Other leaders include Dr. Jeremiah Scharf, who, with Dr. Mathews, co-chairs the Tourette Syndrome Association International Consortium for Genetics (TSAICG), Drs. Jim Knowles and Evelyn Stewart, who co-chair the International Obsessive Compulsive Disorder Genetics Collaborative (IOCDF-GC), Dr. Gerry Nestadt, who chairs the OCD Collaborative Genetics Association Study (OCGAS), and Dr. Matthew State, who chairs TIC Genetics.  Our interdisciplinary membership includes graduate and postdoctoral trainees in psychiatric genetics as well as distinguished faculty in psychiatry, child psychiatry, neurology, psychology, biostatistics, genetics, and genetic epidemiology. Working together we have completed three genome-wide association studies (PMID 228899242288992124821223), and a TS/OCD cross-disorder study (PMID 25158072), as well as a CNV analysis (PMID 25062598), and studies exploring the genetic architecture of Tourette Syndrome and OCD (PMID 24204291).  Our current goals are to expand our sample size for additional genome wide association studies of TS and OCD, and to explore the genetic relationships between these disorders and other neuropsychiatric disorders.

Members of the workgroup stay connected through regular conference calls every third Friday of the month and through a TS/OCD Working group Google group. If you are interested in learning more about the workgroup, please contact Carol Mathews.

If you are a member of the TS/OCD workgroup and have questions about a specific analysis or if you are interested in joining an ongoing project, please contact the investigator leading that project.

Select Publications

Davis, L. K., Yu, D., Keenan, C. L., Gamazon, E. R., Konkashbaev, A. I., Derks, E. M., … Scharf, J. M. (2013). Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genetics, 9(10), e1003864. http://doi.org/10.1371/journal.pgen.1003864

Mattheisen, M., Samuels, J. F., Wang, Y., Greenberg, B. D., Fyer, A. J., McCracken, J. T., … Nestadt, G. (2015). Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Molecular Psychiatry, 20(3), 337–344. http://doi.org/10.1038/mp.2014.43

McGrath, L. M., Yu, D., Marshall, C., Davis, L. K., Thiruvahindrapuram, B., Li, B., … Scharf, J. M. (2014). Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. Journal of the American Academy of Child and Adolescent Psychiatry, 53(8), 910–919. http://doi.org/10.1016/j.jaac.2014.04.022

Scharf, J. M., Yu, D., Mathews, C. A., Neale, B. M., Stewart, S. E., Fagerness, J. A., … Pauls, D. L. (2013). Genome-wide association study of Tourette’s syndrome. Molecular Psychiatry, 18(6), 721–728. http://doi.org/10.1038/mp.2012.69

Yu, D., Mathews, C. A., Scharf, J. M., Neale, B. M., Davis, L. K., Gamazon, E. R., … Pauls, D. L. (2015). Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD. The American Journal of Psychiatry, 172(1), 82–93. http://doi.org/10.1176/appi.ajp.2014.13101306

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