Post-Traumatic Stress Disorder (PTSD)

Workgroup Chairs: Karestan Koenen, Caroline Nievergelt, Israel Liberzon, Kerry Ressler

PTSD Data Access Portal

Our group focuses on the study of Post-Traumatic Stress Disorder (PTSD). The PTSD workgroup has been a part of the PGC since 2012. During that time, our membership has grown to include 81 investigators from 46 institutions representing 7 countries.

Drs. Karestan Koenen, Kerry Ressler, and Israel Liberzon chair our group. The PGC PTSD workgroup also has two subgroups focused on Epigenetics and Imaging Genetics. Drs. Caroline Nievergelt, Monica Uddin, and Alicia Smith lead the Epigenetic subgroup and Drs. Rajendra Morey and Mark Logue lead the Imaging Genetics subgroup. Our interdisciplinary membership includes graduate and postdoctoral trainees in psychiatric genetics as well as distinguished faculty in Psychology, Genetics, Biostatistics, Epidemiology, Psychiatry, and Medicine. Working together we have laid the groundwork for our first large-scale GWAS, which will contain over 3,000 cases and 17,000 controls (see PMC4538342). Our current goals are:

  1. to conduct our first GWAS meta-analysis,
  2. analyze Copy Number Variants (CNVs) and burden measures across PTSD studies in conjunction with the PGC CNV group,
  3. continue increasing the PTSD GWAS dataset through additional genotyping on the PsychChip,
  4. conduct our first Epigenome-Wide Association Study (EWAS) meta-analysis, and
  5. conduct our first Imaging meta-analysis

Members of the workgroup stay connected through regular conference calls the first and third Tuesdays of the month and in-person meetings twice a year at Academic conferences, usually the Society of Biological Psychiatry or Anxiety and Depression Association of America in the Spring and International Society for Traumatic Stress Studies in the Fall.

If you are a member of the PTSD workgroup and have questions about a specific analysis or if you are interested in joining an ongoing project, please contact Dr. Karestan Koenen. If you are interested in learning about the Epigenetics subgroup, please contact Dr. Caroline Nievergelt. If you would like to learn more about the Imaging Genetics subgroup, please contact Dr. Rajendra Morey.

More information about this workgroup can be found at their website: https://pgc-ptsd.com/

Select Publications

Logue, M. W., Amstadter, A. B., Baker, D. G., Duncan, L., Koenen, K. C., Liberzon, I., … Uddin, M. (2015). The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 40(10), 2287–2297. http://doi.org/10.1038/npp.2015.118

Funders
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