Post Traumatic Stress Disorder
If you have questions concerning the projects this workgroup is undertaking, please contact the work group chair(s).
Core Analytical Group Director: Caroline Nievergelt
Data Receiving Committee Representative: Nikolaos Daskalakis
Data Access Committee Representative: Adam Maihofer
PGC-PTSD Electronic Health Records Workgroup Directors: Karestan Koenen
PGC-PTSD Traumatic Brain Injury Workgroup Directors: Seth Disner
PGC-PTSD Local Ancestry Workgroup Directors: Elizabeth Atkinson
PGC-PTSD Microbiome Workgroup Directors: Sian Hemmings
If you have questions concerning this web page or our social media accounts, and/or you have resources that you would like to share with the public, please contact the work group outreach liaison(s).
Data Access Committee (DAC) Representative:
If you have any questions about accessing PGC PTSD data, please contact the DAC representative.PTSD Data Access Portal
The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD) was founded in 2013 with the goal of conducting the first meta-analysis of genome-wide association study (GWAS) data for symptoms and diagnosis of PTSD. During that time, our membership has grown to include data from 60 studies, with over 200 investigators from 12 countries.
Drs. Karestan Koenen, Caroline Nievergelt, Kerry Ressler, and Murray Stein currently chair our group. Our interdisciplinary membership includes graduate and postdoctoral trainees in psychiatric genetics as well as distinguished faculty in Psychology, Genetics, Biostatistics, Epidemiology, Psychiatry, and Medicine. Working together we have laid the groundwork for our first large-scale GWAS, which will contain over 3,000 cases and 17,000 controls (see PMC4538342) and recently followed this work with a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls (see PMC6783435). We are currently looking to increase the number of studies with genotype and clinical information on individuals with PTSD, including those from overlooked ancestry groups. Our current objectives include:
1) Optimize the contribution of diverse ancestry groups in PGC-PTSD to identify causal variants and ensure that advances in our genetic understanding of PTSD extend across ancestral backgrounds.
2) Use post-GWAS approaches to identify functional consequences of variants identified in GWAS meta-analyses and prioritize variants, genes, networks and pathways for functional validation.
3) Use polygenic risk scores (PRS) of PTSD and PTSD components to provide insights into genetic architecture, relation to other disorders, traits and protective factors, and advance causal inference.
We are also seeking to expand our studies by linking genetic data with copy number variations (CNVs), epigenetics, gene expression, brain imaging, physical health, psychophysiology, systems biology, Electronic Health Records (EHR), traumatic brain injury, substance use disorder, local ancestry and microbiome.
Logue, M. W., Amstadter, A. B., Baker, D. G., Duncan, L., Koenen, K. C., Liberzon, I., … Uddin, M. (2015). The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 40(10), 2287–2297. http://doi.org/10.1038/npp.2015.118
Duncan LE, Ratanatharathorn A, Aiello AE, et al. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. 2018;23(3):666‐673. doi:10.1038/mp.2017.77
Nievergelt CM, Maihofer AX, Klengel T, et al. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nat Commun. 2019;10(1):4558. Published 2019 Oct 8. doi:10.1038/s41467-019-12576-w
Complete publication list: