{"id":2216,"date":"2014-07-08T13:15:00","date_gmt":"2014-07-08T17:15:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/pharm\/calabreselab\/calabreselab\/"},"modified":"2025-08-06T05:48:50","modified_gmt":"2025-08-06T09:48:50","slug":"calabreselab","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/","title":{"rendered":"Calabrese Lab"},"content":{"rendered":"
\n

 <\/p>\n

The Calabrese lab at UNC<\/h4>\n

\"\"<\/h6>\n

The lab in May 2023<\/p>\n

From left to right: (top) Shuang, Mickey, Rachel, Elizabeth, Mauro; (bottom) Sam, Aki, Quinn, Ryan, Jackson<\/p>\n

 <\/p>\n

The Calabrese lab seeks to make fundamental discoveries in genomics that unlock innovations in medicine and biotechnology. Our current research focuses on understanding how non-catalytic RNAs (lncRNAs) regulate gene expression inside of the nucleus. For reasons that are not entirely clear, mammalian genomes are pervasively transcribed. However, evidence suggests that prior to export from the nucleus, RNA coordinates a multitude of gene regulatory events that are essential for normal human health and homeostasis. We are working to determine the scope of RNA-mediated gene regulation in mammals, to delineate the relationships between sequence, structure, and function in regulatory RNAs, and to determine the mechanisms that regulatory RNAs employ to control molecular events within the context of the chromatin environment. Given the centrality of gene regulation in human health and disease, we expect our research to lead to discovery of etiologies and therapeutic opportunities in many areas.<\/p>\n

 <\/p>\n<\/div>\n

Motivated individuals interested in genomics, epigenetics, chromatin, or RNA biology are encouraged to email Dr. Calabrese their CV, a brief statement of interest, and the names of 3 references who can speak on their behalf.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

  The Calabrese lab at UNC The lab in May 2023 From left to right: (top) Shuang, Mickey, Rachel, Elizabeth, Mauro; (bottom) Sam, Aki, Quinn, Ryan, Jackson   The Calabrese lab seeks to make fundamental discoveries in genomics that unlock innovations in medicine and biotechnology. Our current research focuses on understanding how non-catalytic RNAs (lncRNAs) … Read more<\/a><\/p>\n","protected":false},"author":3206,"featured_media":0,"parent":0,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2216","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nCalabrese Lab - Calabrese Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calabrese Lab - Calabrese Lab\" \/>\n<meta property=\"og:description\" content=\"  The Calabrese lab at UNC The lab in May 2023 From left to right: (top) Shuang, Mickey, Rachel, Elizabeth, Mauro; (bottom) Sam, Aki, Quinn, Ryan, Jackson   The Calabrese lab seeks to make fundamental discoveries in genomics that unlock innovations in medicine and biotechnology. Our current research focuses on understanding how non-catalytic RNAs (lncRNAs) … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\" \/>\n<meta property=\"og:site_name\" content=\"Calabrese Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-06T09:48:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\",\"name\":\"Calabrese Lab - Calabrese Lab\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg\",\"datePublished\":\"2014-07-08T17:15:00+00:00\",\"dateModified\":\"2025-08-06T09:48:50+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Calabrese Lab\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\",\"name\":\"Calabrese Lab\",\"description\":\"Department of Pharmacology\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Calabrese Lab - Calabrese Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/","og_locale":"en_US","og_type":"article","og_title":"Calabrese Lab - Calabrese Lab","og_description":"  The Calabrese lab at UNC The lab in May 2023 From left to right: (top) Shuang, Mickey, Rachel, Elizabeth, Mauro; (bottom) Sam, Aki, Quinn, Ryan, Jackson   The Calabrese lab seeks to make fundamental discoveries in genomics that unlock innovations in medicine and biotechnology. Our current research focuses on understanding how non-catalytic RNAs (lncRNAs) … Read more","og_url":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/","og_site_name":"Calabrese Lab","article_modified_time":"2025-08-06T09:48:50+00:00","og_image":[{"url":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/","url":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/","name":"Calabrese Lab - Calabrese Lab","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg","datePublished":"2014-07-08T17:15:00+00:00","dateModified":"2025-08-06T09:48:50+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/pharm\/calabreselab\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#primaryimage","url":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg","contentUrl":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-content\/uploads\/sites\/772\/2023\/05\/IMG_8450-scaled-e1683308426614-1024x840.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/"},{"@type":"ListItem","position":2,"name":"Calabrese Lab"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/#website","url":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/","name":"Calabrese Lab","description":"Department of Pharmacology","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/pages\/2216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/users\/3206"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/comments?post=2216"}],"version-history":[{"count":21,"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/pages\/2216\/revisions"}],"predecessor-version":[{"id":2715,"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/pages\/2216\/revisions\/2715"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/wp-json\/wp\/v2\/media?parent=2216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}