For the first time, UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.
UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.
Dr. David Lawrence Scientists at the University of North Carolina at Chapel Hill have developed a breakthrough technique that uses light to activate a drug stored in circulating red blood cells so that it is released exactly when and where it is needed. The work, led by Fred Eshelman Distinguished Professor David Lawrence in … Read more
UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.
UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is “Engineering extrinsic disorder to control protein activity in living cells.”
Congratulations to Brent Asrican, Research Assistant Professor in the Song Lab, for receiving a prestigious Junior Faculty Development Award! The award, which he was notified of this week, will provide support to Brent’s research in 2017. Brent proposes to use electrophysiology, optogenetics and chemogenetics to determine how neuropeptides, such as CCK, interact with neuronal circuits … Read more
Jones Lab paper featured on cover on Science Signaling September 20, 2016 issue View Cover The Online Cover “features a Research Article that describes the evolution and function of two distinct families of Gα proteins in plants. The XLG family is similar to the hare, rapidly evolving to enable adaptation to living on land; whereas … Read more
Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.
The new compound could reduce overdoses and possibly curb addiction, while addressing the needs of millions of people suffering with chronic pain.
The Song lab will use the fund to study the cellular targets of Zika Virus (ZIKV) in the adult brain using a mouse model of ZIKV pathogenesis.
