Solving a 40-year-old mystery, UNC researchers find new route for better brain disorder treatments
New targeted therapies for pain, Parkinson’s disease, and depression carry the promise of greater benefit for patients without serious side effects.
New targeted therapies for pain, Parkinson’s disease, and depression carry the promise of greater benefit for patients without serious side effects.
In a paper published in Nature Neuroscience on November 10, Juan Song discovers how baby neurons stay alive, a key finding for understanding neurodegenerative diseases, such as Alzheimer’s.
Klaus Hahn (Pharmacology), John Sondek (Pharmacology), Keith Burridge (Cell and Developmental Biology), Alan Hall (Sloan-Kettering Institute), and Gaudenz Danuser (UT Southwestern) have been awarded a 5-year Program Project Grant from the National Institutes of Health to study GEF/Rho GTPase signaling circuitry.
The September 2013 issue of UNC Medical Builletin highlights Zefeng Wang’s paper about gene splicing, introns and splicing repression in the January 2013 issue of Nature Structural and Molecular Biology, “A complex network of factors with overlapping affinities represses splicing through intronic elements.”
Dr. Mike Emanuele, recipient of V Foundation for Cancer Research Award Dr. Mike Emanuele has received a V Scholar Award from the V Foundation for Cancer Research. The title of Mike’s research proposal is “Identification of ubiquitin signaling networks as novel avenues for therapeutic intervention.” Mike’s award is for $200,000 over 2 years. Our congratulations … Read more
Dr. Juan Song, Ph.D. and Dr. Mauro Calabrese, Ph.D. have joined the Pharmacology Department as Assistant Professors. Dr. Song will begin in September, 2013 and Dr. Calabrese will join us starting in March, 2014. Meet Dr. Song and Dr. Calabrese A few words from Dr.Juan Song to introduce herself: I’ll be starting as an Assistant … Read more
Dr Henrik Dohlman, newly elected Associate Editor for JBC Henrik Dohlman, Ph.D., a joint faculty member of the Department of Pharmacology has been elected as an Associate Editor for the Journal of Biological Chemistry (JBC). Dr. Dohlman is currently an editorial board member of JBC with https://www.med.unc.edu/pharm/directory/henrik-dohlman-phd/an area of expertise in signal transduction. He will … Read more
In the first application of this approach, the UNC researchers showed how a protein called Src kinase influences the way cells extend and move, a previously unknown role that is consistent with the protein’s ties to tumor progression and metastasis.
The Roth Lab in collaboration with Ray Stevens’ Lab at Scripps Research Institute had 2 papers published on Science’s advanced online publishing website, Science Express, March 21, 2013. The papers describe the structure of serotonin receptors and how the structure of the receptors shapes drug effects.
Canavan disease is an autosomal recessive degenerative neurological disorder caused by defective ASPA gene. ASPA is responsible for the production of the enzyme aspartoacylase, an enzyme essential for breaking down concentrated brain molecule N-acetyl aspartate. The lack of this breakdown interferes with growth of myelin sheath of the nerve fiber, and as a result, symptoms … Read more