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Scientists Elucidate How DREADD Technology Highjacks Neuronal Activity

December 8, 2022

The Bryan Roth lab got some nice press for their recent Nature paper, revealing structural details of his chemogenetic technology called DREADD – designer receptors exclusively activated by designer drugs – that recognize drug-like but physiologically inert compounds. Postdoc Shicheng Zhang, PhD, led this research published in Nature.

Scientists Create Non-Psychedelic Compound with Same Anti-depressant Effect

October 14, 2022

The Roth Lab and collaborators from UC San Francisco, Yale, Duke, and Stanford developed a new compound that hits the same brain cell target as psychedelic drugs, triggering long-lasting anti-depressant action without psychedelic effects in mice. Kuglae Kim is co-first author of the Nature paper.