Category: Faculty News
Two genomic-based studies from Heart Healthy Lenoir were published in the last month. Heart Healthy Lenoir was a multidisciplinary research project that aimed to reduce cardiovascular disease in Lenoir County, North Carolina by developing new approaches to care, from prevention to treatment. The lead investigator of the Heart Healthy Lenoir genomics study is Jonathan Schisler, PhD, assistant professor in the Department of Pharmacology and McAllister Heart Institute.
Published in Nature, research from the lab of Bryan L. Roth, MD, PhD, Distinguished Professor of Pharmacology, revealed the first-ever crystal structure of the dopamine 2 receptor bound to an antipsychotic drug – a much-needed discovery in the quest to create effective drugs with fewer side effects to treat bipolar disorder, schizophrenia, and other conditions.
In a paper published in Cell, research led by Bryan Roth, MD, PhD, and Roth lab members, Tao Ch, PhD and Daniel Wacker, PhD, show how to activate only one kind of brain receptor vital for pain relief. This receptor is not involved in addiction or respiratory depression that leads to death – the most severe side effects of opioid use.