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Dr. Saran successfully defended her PhD, “Bile Acid Transporters and Hepatotoxicity: Novel Mechanisms and in Vitro Models,” on April 19.

Dr. Chitra Saran after successfully defending her PhD, April 19, 2022.

Title of Defense talk: “Bile Acid Transporters and Hepatotoxicity: Novel Mechanisms and in Vitro Models” 

Mentor: Dr. Kim Brouwer

Highlights& Awards

Pharmacology Student Scholar Award 2020

Journal of Pharmacology and Experimental Therapeutics Highlighted Trainee Author for the February 2022 issue

Invited Presentation – ISSX Webinar titled “Mechanistic Insights into the Role of Transporters in Drug Pharmacokinetics, Toxicology and Physiology”

Publications

Brouwer KLR, Evers R, Hayden E, Hu S, Li CY, Meyer Zu Schwabedissen HE, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl J, Stahl SH, Yue W. Regulation of Drug Transport Proteins – From Mechanisms to Clinical Impact; A White Paper on Behalf of the ITC. Clin Pharmacol Ther. 2022 Apr 7. doi: 10.1002/cpt.2605. Epub ahead of print. PMID: 35390174.

Saran C, Sundqvist L, Ho H, Niskanen J, Honkakoski P, Brouwer KLR. Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors. J Pharmacol Exp Ther. 2022 Feb;380(2):114-125. doi: 10.1124/jpet.121.000828. Epub 2021 Nov 18. PMID: 34794962.

Saran C, Beaudoin JJ, Pfeifer ND, Brouwer KLR: Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes. In: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery: Methods in Pharmacology and Toxicology, Springer, 2021.

Murphy WA, Saran C, Honkakoski P and Brouwer KLR: Mechanism-Based Experimental Models for the Evaluation of BSEP Inhibition and DILI. In: Transporters and Drug Metabolizing Enzymes in Drug Toxicity, Wiley, 2021.

Bezençon J, Saran C, Hussner J, Beaudoin JJ, Zhang Y, Shen H, Fallon JK, Smith PC, Meyer Zu Schwabedissen HE, Brouwer KLR. Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR) Rats. J Pharm Sci. 2021 Jan;110(1):404-411. doi: 10.1016/j.xphs.2020.10.017. Epub 2020 Oct 13. PMID: 33058892; PMCID: PMC7767637.

Kang HE, Malinen MM, Saran C, Honkakoski P, Brouwer KLR. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions. Drug Metab Dispos. 2019 Oct;47(10):1222-1230. doi: 10.1124/dmd.119.087676. Epub 2019 Aug 1. PMID: 31371422; PMCID: PMC6756293.

 

Pics from Chitra’s defense. Click for larger images.

Congratulations, Chitra, we are very proud of you! We wish you all the best!