Dr. Fennell defended her thesis, “Profiling the Multi-omic Response to Mitochondrial Protease ClpP Activation in Triple-Negative Breast Cancer Cells,” November 22!
Mentor: Dr. Lee Graves
Thesis title: “Profiling the Multi-omic Response to Mitochondrial Protease ClpP Activation in Triple-Negative Breast Cancer Cells”
Publications
Graves PR, Aponte-Collazo LJ, Fennell EMJ, Graves AC, Hale AE, Dicheva N, Herring LE, Gilbert TSK, East MP, McDonald IM, Lockett MR, Ashamalla H, Moorman NJ, Karanewsky DS, Iwanowicz EJ, Holmuhamedov E, Graves LM. Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues. ACS Chem Biol. 2019 May 17;14(5):1020-1029. https://doi.org/10.1021/acschembio.9b00222. Epub 2019 May 1. Erratum in: ACS Chem Biol. 2022 Aug 19;17(8):2377-2378. PMID: 31021596; PMCID: PMC6528275.
Fennell EMJ, Aponte-Collazo LJ, Wynn JD, Drizyte-Miller K, Leung E, Greer YE, Graves PR, Iwanowicz AA, Ashamalla H, Holmuhamedov E, Lang H, Karanewsky DS, Der CJ, Houry WA, Lipkowitz S, Iwanowicz EJ, Graves LM. Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP. Pharmacol Res Perspect. 2022 Aug;10(4):e00993. https://doi.org/10.1002/prp2.993. PMID: 35929764; PMCID: PMC9354705.
Greer YE, Hernandez L, Fennell EMJ, Kundu M, Voeller D, Chari R, Gilbert SF, Gilbert TSK, Ratnayake S, Tang B, Hafner M, Chen Q, Meerzaman D, Iwanowicz E, Annunziata CM, Graves LM, Lipkowitz S. Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis. Cancer Res Commun. 2022 Oct 10;2(10):1144-1161. https://doi.org/10.1158/2767-9764.CRC-22-0142. PMID: 36388465; PMCID: PMC9645232.
Lucas J. Aponte-Collazo, Emily M. J. Fennell, Michael P. East, Thomas S. K. Gilbert, Paul R. Graves, Hani Ashamalla, Edwin J. Iwanowicz, Yoshimi Endo Greer, Stanley Lipkowitz, Lee M. Graves. Small Molecule ClpP agonists induce senescence and alter trail-mediated apoptotic response of triple-negative breast cancer cells. bioRxiv. 2022.07.11.499620; doi: https://doi.org/10.1101/2022.07.11.499620
Awards & Highlights
2021 UNC Pharmacology Thomas Collum Butler Award