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Dr. Taylor Enrico successfully defended her PhD, “Control of Proliferation by the Ubiquitin Proteasome System,” on March 4.

Taylor Enrico, PhD

Title of defense talk: “Control of Proliferation by the Ubiquitin Proteasome System”

Mentor: Dr. Michael Emanuele

Dr. Enrico will be starting a new position as a consultant with Boston Consulting Group in Boston.

Highlights & Awards

2021 – Thomas Collum Butler Award, UNC Pharmacology

Publications

Enrico TP, Stallaert W, Wick ET, Ngoi P, Wang X, Rubin SM, Brown NG, Purvis JE, Emanuele MJ. Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. Elife. 2021 Dec 1;10:e70691. doi: 10.7554/eLife.70691. PMID: 34851822; PMCID: PMC8670743.

Wasserman D, Nachum S, Noach-Hirsh M, Auerbach N, Sheinberger-Chorni E, Enrico TP, Lahmi R, Emanuele MJ, Tzur A. Elucidating Human Mitosis Using an Anaphase-Like Cell-Free System. Methods Mol Biol. 2021;2329:143-164. doi: 10.1007/978-1-0716-1538-6_11. PMID: 34085221; PMCID: PMC8628539.

Franks JL, Martinez-Chacin RC, Wang X, Tiedemann RL, Bonacci T, Choudhury R, Bolhuis DL, Enrico TP, Mouery RD, Damrauer JS, Yan F, Harrison JS, Major MB, Hoadley KA, Suzuki A, Rothbart SB, Brown NG, Emanuele MJ. In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. PLoS Biol. 2020 Dec 11;18(12):e3000975. doi: 10.1371/journal.pbio.3000975. PMID: 33306668; PMCID: PMC7758050.

Emanuele MJ, Enrico TP, Mouery RD, Wasserman D, Nachum S, Tzur A. Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin. Trends Cell Biol. 2020 Aug;30(8):640-652. doi: 10.1016/j.tcb.2020.05.002. Epub 2020 Jun 5. PMID: 32513610; PMCID: PMC7859860.

Wasserman D, Nachum S, Cohen M, Enrico TP, Noach-Hirsh M, Parasol J, Zomer- Polak S, Auerbach N, Sheinberger-Chorni E, Nevenzal H, Levi-Dadon N, Wang X, Lahmi R, Michaely E, Gerber D, Emanuele MJ, Tzur A. Cell cycle oscillators underlying orderly proteolysis of E2F8. Mol Biol Cell. 2020 Apr 1;31(8):725-740. doi: 10.1091/mbc.E19-12-0725. Epub 2020 Jan 29. PMID: 31995441; PMCID: PMC7185961.

Emanuele MJ, Enrico TP. Ubiquitin Signaling in Regulation of the Start of the Cell Cycle. In: Summers M, ed. Ubiquitin Proteasome System: Current Insights in Mechanism, Cellular Regulation, and Disease. London; 2019:3-23.

Congratulations, Taylor, we are very proud of you!  We wish you all the best!