Dr. Graboski successfully defending her thesis, “Characterization and Inhibition of Gut Microbial Tryptophanase and its Implications in Chronic Kidney Disease” under the guidance of Professor Matt Redinbo on September 21.
Dr. Graboski has accepted a scientist position in Boston at Scorpion Therapeutics in their Protein and Structural Sciences division. In this role she will collaborate with computational and medicinal chemists to identify druggable protein regions, make and co-crystallize these proteins, and inform drug design using structural data.
Publications
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Graboski AL, Kowalewski ME, Simpson JB, Cao X, Ha M, Zhang J, Walton WG, Flaherty DP, Redinbo MR. Cell Chem Biol. 2023 Aug 12:S2451-9456(23)00244-1. doi: 10.1016/j.chembiol.2023.07.015. Online ahead of print. PMID: 37633277 Free article.
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate. Simpson JB, Sekela JJ, Graboski AL, Borlandelli VB, Bivins MM, Barker NK, Sorgen AA, Mordant AL, Johnson RL, Bhatt AP, Fodor AA, Herring LE, Overkleeft H, Lee JR, Redinbo MR. Gut Microbes. 2022 Jan-Dec;14(1):2107289. doi: 10.1080/19490976.2022.2107289. PMID: 35953888 Free PMC article.
Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis. Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, Rojas JD, Dayton PA, Huang L, Wang AZ. Cancer Res. 2022 Jan 1;82(1):105-113. doi: 10.1158/0008-5472.CAN-21-2269. Epub 2021 Nov 9. PMID: 34753773 Free PMC article.
Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae. Hewitt CS, Abutaleb NS, Elhassanny AEM, Nocentini A, Cao X, Amos DP, Youse MS, Holly KJ, Marapaka AK, An W, Kaur J, Krabill AD, Elkashif A, Elgammal Y, Graboski AL, Supuran CT, Seleem MN, Flaherty DP. ACS Infect Dis. 2021 Jul 9;7(7):1969-1984. doi: 10.1021/acsinfecdis.1c00055. Epub 2021 Mar 25. PMID: 33765392 Free PMC article.
Gut-Derived Protein-Bound Uremic Toxins. Graboski AL, Redinbo MR. Toxins (Basel). 2020 Sep 11;12(9):590. doi: 10.3390/toxins12090590. PMID: 32932981 Free PMC article. Review.
Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus. Kaur J, Cao X, Abutaleb NS, Elkashif A, Graboski AL, Krabill AD, AbdelKhalek AH, An W, Bhardwaj A, Seleem MN, Flaherty DP. J Med Chem. 2020 Sep 10;63(17):9540-9562. doi: 10.1021/acs.jmedchem.0c00734. Epub 2020 Aug 11. PMID: 32787141 Free PMC article.
Awards & Highlights
Merck/Women Chemists Committee (WCC) Research Award, 2/23/2023 – The award provides a stipend for travel expenses to the ACS Symposium in San Francisco this fall where she will present her research.
Appointed to the Pharmacological Sciences T32 from 2020-2022 and to the Kidney Center T32 from 2022-2023.
Amanda is also an inventor on a provisional patent that was filed!
We wish you all the best, Amanda!