Dr. Seth Rubin of UC Santa Cruz presents

Seth Rubin, PhD
Professor
Department of Chemistry and Biochemistry
UC Santa Cruz

Title of Talk: “Noncanonical activators and pharmacological inhibitors of cyclin dependent kinases”

This seminar will be in 1131 Bioinformatics.

Please join us and show support for our seminar speakers!

(For those unable to attend, a zoom link is available upon request to April Villanueva.)

Host: Mike Emanuele

Dr. Rubin studies the role of the CDK-RB pathway and its regulation. His research is at the intersection of kinase signaling and gene regulation. This pathway is of vital importance to many cancer types. He approaches this important question using a variety of structural biology approaches.

“Our broad research interests are in understanding the biochemical mechanisms that control the cell cycle. Cell growth and division are carefully coordinated by a shifting network of biomolecular interactions. Protein interactions regulate enzymatic activities responsible for key cell cycle events such as DNA replication, chromosome segregation, and cytokinesis. These events have strict spatial and temporal requirements for proper cell cycle function, and deregulation of protein interaction networks is commonly associated with aberrant cell proliferation and cancer. Understanding mechanisms of cell cycle control requires a detailed molecular picture of protein-protein interactions and how these interactions regulate enzymatic function and cellular architecture. Our laboratory seeks to elucidate the biochemical determinants of protein interaction affinity and specificity and how these factors are affected by regulatory modifications to protein composition and structure. We apply a variety of structural and biochemical techniques to learn in molecular detail how structural changes and chemical modifications affect biological function.”
~ https://rubinlab.sites.ucsc.edu/people-2/