Fall 2020

Please email arnoldn@email.unc.edu to register for all PHCO courses.

PHCO 701 – Introduction to Molecular Pharmacology*

(3 cr. hr)
M/W/F @ 9:05 – 9:50 am (Full semester course)
Location: TBA
Course Director: Dr. Terry Kenakin
Course Outline
Course Description This is a graduate-level first year course outlining the basics of molecular pharmacology, including molecular biology, bioinformatics, drug/receptor interactions, receptor and ion channels, regulation of second messengers, drug metabolism and system pharmacology. Permission of the instructor required for registration. Three credit hours a week.

Course objectives (learning outcomes): The objectives of this course are to provide graduate students in biomedical research programs familiarity with the molecular principles of pharmacology involved in the design and action of drugs. Students will increase critical thinking skills in the context of the specific topics listed in the syllabus, which includes molecular biology underlying drug development, key drugable pathways and the interactions between drugs and human body. By the end of this course students should be familiar with molecular principles of drug development including knowledge of gene expression pathways related to drugs, key drugable targets and the interaction between drugs and their receptors. Students should have working knowledge sufficient to apply those principles to new research topics and to propose appropriate strategies to solve relevant research questions.

PHCO 732 – Fellowship/Grant Writing* 

(2 cr. hr)
Time: TBA
Location: TBA
Course Director: Dr. Adrienne Cox
Course Outline

PHCO 740-750 Contemporary Topics in Cell Signaling.

Prerequisites, students are expected to have had undergraduate courses in biochemistry and cell & molecular biology or to have acquired knowledge in those fields. Permission required of each module leader. Each module is taught in 5-week blocks and will investigate principles and mechanisms of signal transduction and cell proliferation control with an emphasis on in-depth discussion of current literature and unanswered questions in the field. Modules are team-taught as a combination of lectures and discussions with major themes repeating no less frequently than alternate years (740-742 & 750 typically taught consecutively in odd-numbered years, and 743-745 in even-numbered years). Themes include protein kinases, GTPases, cell cycle control, signaling specificity and feedback (networks), tumor suppressors and oncogenes, signaling in development and stem cell biology, and intercellular signaling in development and disease.

Module 1 – PHCO 750 Proteomics Methods and Applications*

( 1 cr. hr)
Location: TBA
Course Director: Dr. Laura Herring
Course Outline

Topics include:

  • Introduction to mass spectrometry-based proteomics
  • Proteomics applications such as post-translational modification identification, protein-protein interaction analysis, expression proteomics, kinome profiling – with real data!
  • Practical considerations when conducting a proteomics experiment (experimental design, controls, sample preparation)
  • Statistical and bioinformatics analysis of proteomics data
  • Hands-on experience in the lab


***Email arnoldn@email.unc.edu to register for all PHCO courses. Meeting times may change to accommodate schedules.

Tuesdays, PHCO Dept Seminars, 4 p.m

Fridays, PHCO Student Research Seminars, 12 p.m.

Link to Quantitative Skills Resources

Link to UNC Academic Calendar

View Spring 2020 Class Schedule