Class Schedules – Fall 2019
Fall 2019
Please email arnoldn@email.unc.edu to register for all PHCO courses.PHCO 701 – Introduction to Molecular Pharmacology*
(3 cr. hr)
M/W/F @ 9:05 – 9:50 am (Full semester course)
4007 Genetic Medicine Building
Course Director: Dr. Terry Kenakin
Course Outline
PHCO 732 – Fellowship/Grant Writing
(2 cr. hr)
**Starts September 11, will meet on Wednesdays @ 10:00 am – 12:00 pm
**Starting on October 23, will meet on Thursdays @ 10:00 am – 12:00 pm
4007 Genetic Medicine Building
Course Director: Dr. Adrienne Cox
Course Outline
PHCO 737 – Target-based Anticancer Drug Discovery and Development
(2 cr. hr)
**Must have permission of Dr. Cox to register
**Starts September 6
Friday @ 10:00 – 11:50 am
Location: Varies by date, please see below.
Course Instructors: Dr. Adrienne Cox and Dr. Channing Der
| Date | Location |
|---|---|
| 9/06 | Marsico 2004 |
| 9/13 | LCCC 12-001 |
| 9/20 | Marsico 2004 |
| 9/27 | Marsico 2004 |
| 10/04 | Marsico 2004 |
| 10/11 | LCCC 12-001 |
| 10/18 | Marsico 2004 |
| 10/25 | Marsico 2004 |
| 11/01 | Marsico 2004 |
| 11/08 | LCCC 12-001 |
| 11/15 | Marsico 2004 |
| 11/22 | Marsico 2004 |
| 12/06 | MEJ 3104 |
| 12/13 | LCCC 12-001 |
Course Description:
The number of signal transduction-targeted anticancer drugs entering the clinic has increased dramatically in recent years, with many more in the pipeline. This course covers the process and complexity of targeted drug development for cancer treatment. It includes lectures, student-led discussions of relevant papers selected by faculty, and a team-based semester-long project in which students will select a real target and then develop mock data in support of a mock drug directed against that target. Teams will make presentations to convince “venture capitalists” (i.e., lead instructors) that they have identified viable candidates for support as targeted anti-cancer drugs of the future. Mock investments, real grades and prizes will be awarded. Several teams from previous classes developed mock drugs that had high degrees of similarity to eventual real drugs.
Topics include:
- Conventional cancer chemotherapy
- Target identification and validation
- Identification of hits – high-throughput screening, rational drug design, lead identification
- Lead compound evaluation – in vitro to cell-based assays
- Lead compound evaluation – preclinical animal studies
- Clinical trials – design and implementation
- Roles of academia, industry, and government
- State of the art – what is in the pipeline?
The course is directed by Drs. Adrienne Cox and Channing Der. They have served as consultants for the drug discovery programs of numerous pharmaceutical companies, and target-based drug discovery is an essential and significant component of their research programs. Their research has been funded in part by a National Cooperative Drug Discovery Grant from the NIH.
PHCO 740-750 Contemporary Topics in Cell Signaling.
Prerequisites, students are expected to have had undergraduate courses in biochemistry and cell & molecular biology or to have acquired knowledge in those fields. Permission required of each module leader. Each module is taught in 5-week blocks and will investigate principles and mechanisms of signal transduction and cell proliferation control with an emphasis on in-depth discussion of current literature and unanswered questions in the field. Modules are team-taught as a combination of lectures and discussions with major themes repeating no less frequently than alternate years (740-742 & 750 typically taught consecutively in odd-numbered years, and 743-745 in even-numbered years). Themes include protein kinases, GTPases, cell cycle control, signaling specificity and feedback (networks), tumor suppressors and oncogenes, signaling in development and stem cell biology, and intercellular signaling in development and disease.
Module 1 – PHCO 750 Proteomics Methods and Applications – Starts Oct. 28
**Starts October 28, for 5 weeks
M/W @ 10:30 am – 12:00 pm
( 1 cr. hr)
4007 Genetic Medicine Building
Course Director: Dr. Laura Herring
Course Outline
Topics include:
- Introduction to mass spectrometry-based proteomics
- Proteomics applications such as post-translational modification identification, protein-protein interaction analysis, expression proteomics, kinome profiling – with real data!
- Practical considerations when conducting a proteomics experiment (experimental design, controls, sample preparation)
- Statistical and bioinformatics analysis of proteomics data
- Hands-on experience in the lab
***Email arnoldn@email.unc.edu to register for all PHCO courses. Meeting times may change to accommodate schedules. Tuesdays, PHCO Dept Seminars, 4 p.m
Tuesdays, PHCO Dept Seminars, 4 p.m