Please email to register for all PHCO courses.

PHCO 702 – Principles of Pharmacology & Physiology

Permission of the instructor required. Introduces the major areas of pharmacology and physiology and serves as a basis for most advanced courses in Pharmacology. Three lecture hours a week. Lecture Course

(3 Credits)
Full Semester Course
M/W/F 9:00 – 9:50 am
4007 Genetic Medicine Bldg.
Dr.Terry Kenakin, Course Director
Course Outline

PHCO 740-745 Contemporary Topics in Cell Signaling.

Prerequisites, students are expected to have had undergraduate courses in biochemistry and cell & molecular biology or to have acquired knowledge in those fields. Permission required of each module leader. Each module is taught in 5-week blocks and will investigate principles and mechanisms of signal transduction and cell proliferation control with an emphasis on in-depth discussion of current literature and unanswered questions in the field. Modules are team-taught as a combination of lectures and discussions with major themes repeating no less frequently than alternate years (740-742 typically taught consecutively in odd-numbered years, and 743-745 in even-numbered years). Themes include protein kinases, GTPases, cell cycle control, signaling specificity and feedback (networks), tumor suppressors and oncogenes, signaling in development and stem cell biology, and intercellular signaling in development and disease.

Spring 2018 PHCO 740-745 Offerings:

PHCO 745 – Intercellular Signaling in Development & Disease.

(1 Credit)
(5 weeks Module) Jan 9 – Feb 8
T/TH 2 PM-3:30 PM
5007 Genetic Medicine Bldg ***ROOM CHANGE
Dr. Yuliya Pylayeva-Gupta
Course Outline

This graduate-level course concentrates on up-to-date views of intercellular signal processing, with emphasis on signal transduction mechanisms as they relate to cellular/physiological responses in both normal development and disease. Signaling mechanisms that will be discussed include paracrine, juxtacrine signaling and cell-matrix interactions. Model systems will include examples from neurobiology, gastrointestinal biology, cardiovascular system and immune system. The role of intercellular signaling and its targeting in cancer will be discussed. The course format will combine lectures and in-class discussion of assigned readings, with particular emphasis on state-of-the-art research methods to study cell signaling between cells. In addition to materials focused on recent advances, hallmark historical papers will be discussed. Students are expected to have prior knowledge of genetics, cell biology and molecular biology. Be advised this course does start on January 9.

PHCO 744-Stem Cell Biology and Regenerative Medicine

(2 credit)
(10 weeks module) Feb 13 – April 24
T/TH 9:30 AM-10:45 AM
3007 Genetic Medicine Bldg.
Dr. Steve Crews
Course Outline

This graduate-level course addresses key issues in stem cell biology and regenerative medicine while providing insights into important aspects of developmental biology, stem cell technology, and human disease. Experimental systems to be studied include human stem cells as well as the mouse, zebrafish, and Drosophila model systems. Cell types to be explored include iPS and ES cells, the nervous system, epidermis, intestine, and cardiovascular system. The role of stem cells in human oncogenesis and their therapeutic use in human disease will be discussed. The class format combines lectures and in-class discussion of assigned readings selected from both seminal works and recent articles. Students are expected to have taken courses in genetics, cell biology, and molecular biology or to have acquired knowledge in those fields.

PHCO 749 – Practical RNA-SEQ

(2 cr hr)
M/W/F 1:30 – 3:00pm – (March 19 – April 30)
Health Science Library Biogen Idec Room 307
Drs. Mauro Calabrese, Hemant Kelkar, Joel Parker
Course Outline

This module is designed to familiarize students with everything needed to run an RNA-Seq experiment, including the concepts behind experimental design, how to prepare samples, running them on a NextSeq 500, and analyzing data. There will be minimal emphasis on theory and heavy focus on practical aspects. There are no formal prerequisites required for this course and no prior experience with UNIX or the command line interface is expected. Registration is by Mauro Calabrese consent, and before registering, students need to send Mauro Calabrese a 250 word essay about why they will be using RNA-seq. (March 19-April 30). Module Lab Course.

***Email to register for all PHCO courses. Meeting times may change to accommodate schedules. Tuesdays, PHCO Dept Seminars, 4 p.m

Tuesdays, PHCO Dept Seminars, 4 p.m

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