{"id":2254,"date":"2013-09-04T18:30:00","date_gmt":"2013-09-04T22:30:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/johnsonlab\/publications\/"},"modified":"2020-08-24T16:27:32","modified_gmt":"2020-08-24T20:27:32","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pharm\/johnsonlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
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Journal Highlights<\/h2>\n

Cover of Journal of Cell Biology April 16, 2010<\/strong>\"Johnson<\/strong>
\n“Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype.” <\/i><\/strong><\/span><\/p>\n

About the cover:<\/strong> Cerebral cavernous malformations (CCM) are vascular lesions causing seizure and stroke. Mutations in one of three genes, ccm1, ccm2,<\/em> or ccm3,<\/em> cause an increase in RhoA expression and activation. Increased RhoA and Rho kinase activity inhibits endothelial cell vessel-like tube formation. A small molecule inhibitor of Rho kinase rescues the CCM endothelial cell phenotype, defining Rho kinase as a therapeutic target to rescue endothelial cells from loss of CCM protein function. For details see the article by Borikova et al<\/em>., pages 11760\u201311764 (online at JBC).<\/a><\/strong>
\nView larger cover image<\/a><\/strong><\/p>\n

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Selected Recent Publications<\/h2>\n