Journal Highlights

Journal Covers and highlighted articles by Pharmacology faculty.
Click on images for larger views.
dashed line
Song Lab - Bao and Crowther Stem Cell Reports Cover 2018

SongLab - Cover of Stem Cell Reports March 13, 2018

Andrew J. Crowther*, A.J., Szu-Aun Lim*, Brent Asrican, Blake H. Albright, Josh Wooten, Chia-Yu Yeh, Hechen Bao, Domenic H. Cerri, Jessica Hu, Yen-Yu Ian Shih, Aravind Asokan, Juan Song. An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus. Stem Cell Reports 10(3): 1146–1159, 2018. PMC5918266 *Co-first authors. Cover credit: Hechen Bao, Mengting Dai, and Andrew Crowther.  online article | pubmed

dashed line
On the cover: In this issue, Bao et al. (604–617) show that long-range GABAergic projections from medial septum (MS) are necessary and sufficient for regulating neurogenesis through dentate local PV interneurons. The cover image is an artistic modification of the MS GABAergic projections acquired from Micro-Optical Sectioning Tomography (MOST) by Dr. Hui Gong from HUST. Flying birds allude to messengers sending GABA transmitter to the neurogenic niche. The lake and forest pictured below represent local PV interneurons nourishing neural stem cells. Cover designed by Hechen Bao and Mengting Dai.

SongLab - Cover of Cell Stem Cell November 2, 2017

Bao, Hechen*, African, Brent*, Li, W.*, Gu, B., Wen, Z., Lim, S.A., Haniff, I., Ramakrishnan, C., Deisseroth, K., Philpott  B., Song, J. Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 21(5): 604-617.e5, 2017. doi: 10.1016/j.stem.2017.10.003. PMC5689456 *Co-first authors. Cover credit: Hechen Bao and Mengting Dai. UPDATE: This article and cover were selected by Cell Stem Cell as one of eight "Best Articles" in 2017 and one of five "Best Covers" in 2017!  online article | pubmed
dashed line
Alan Jones Science Signaling Cover

Jones Lab - Cover of The Journal of Science Signaling September 20, 2016

"Saltatory evolution of the heterotrimeric G protein signaling mechanisms in the plant kingdom," Urano, D, et al., Science Signaling, 9(446): ra93, 2016. doi: 10.1126/scisignal.aaf9558. online article | pubmed

dashed line
Song Lab Cover of J. Neuroscience May 2016 - 100

Song Lab - Cover of The Journal of Neuroscience May 4, 2016.

"Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory,"Winkle and Olsen, et al., J. Neuroscience, 36(18): 4940-4958, 2016. online article | pubmed

dashed line
Nature Neuroscience 100

Song Lab - Paper Published in Nature Neuroscience November 2013.

"Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus." Song et al., Nature Neuroscience 16: 1728-1730, 2013. online article | pubmed

dashed line
Samulski Science Translational Medicine 100

Samulski Lab - Paper Published in Science Translational Medicine, December 2012.

"Follow-Up After Gene Therapy for Canavan Disease." Leone et al., Science Translational Medicine Vol. 4, Issue 165, p. 165ra163, 2012. DOI: 10.1126/scitranslmed.3003454. doi:10.1038/nsmb.2377. online article

dashed line
Jobin lab Science paper - 100

Jobin Lab - Paper Published in Science, October, 2012.

"Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota." Arthur et al., Science 338 (6103): 120-123, 2012. doi:10.1038/nsmb.2377. online article

dashed line
Wang-Fig. 1 - 100

Wang Lab - Paper Published in Nature Sturctural & Molecular Biology Sept. 16, 2012.

"Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules." Nature Struct Mol Biol., published online doi:10.1038/nsmb.2377. online article

dashed line
Positive roles for negative regulators in the mating response of yeast - Elston lab 100

Elston Lab -  Paper Nominated as Being of Special Significance by F1000. 7, 2012

"Positive roles for negative regulators in the mating response of yeast." Mol.Sys. Biol., June 5, 2012. online article

Anuj Kumar and Cole Johnson's article in F1000 Research on the paper's special significance for the field of Genomics & Genetic: July 20, 20112.

dashed line
Johnson Lab Cell Stem Cell 100

Johnson Lab - Cell Stem Cell publication May 6, 2011.

"MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells." Cell Stem Cell  8(5): 525-537, 2011.   online article

Commentary: "An Epigenetic Mark that Protects the Epithelial Phenotype in Health and Disease" in Cell Stem Cell 8(5): 462-463, 2011. online article

dashed line
Dohlman Lab Science Signaling Image sm

Dohlman Lab - Science Signaling publication February 8, 2011.

Highlighted in Science  Editor's Choice February 25, 2011 as "Cell Signaling: Receptor Free Signaling."

"The Crystal Structure of a Self-Activating G Protein Alpha Subunit Reveals Its Distinct Method of Signal Initiation." Science Signaling 4(159): ra8, 2010. online article

dashed line
Dohlman Lab Mol Cell image - 100

Dohlman Lab - Molecular Cell publication June 11, 2010.

Highlighted in Science Signaling Editor's Choice June 29, 2010 as "G Protein Signaling Is Not a Done Deal."

"Systematic Analysis of Essential Genes Reveals Important Regulators of G Protein Signaling." Molecular Cell 38(5): 746-757, 2010. online article
dashed line
Harden and Sondek Labs Science 100

Harden Lab and Sondek Lab - Science publication October 21, 2010.

"Kinetic Scaffolding Mediated by a Phospholipase C-β and Gq Signaling Complex." Science 330: 974-980, 2010.  online article

dashed line
Whitehurst MCB Cover

Whitehurst Lab - Cover of Molecular and Cellular Biology, Nov., 2010.

"Symplekin Specifies Mitotic Fidelity by Supporting Microtubule Dynamics."  Mol Cell Biol. 30(21):5135-44, 2010. online article

dashed line
Whitehurst Cancer Research 2010

Whitehurst Lab - Publication highlighted on cover of Cancer Research, October 1, 2010.

"Tumor Antigen Acrosin Binding Protein Normalizes Mitotic Spindle Function to Promote Cancer Cell Proliferation."  Cancer Res. 70(19): 7652-7661, 2010. online article

dashed line
Hahn - Nature Reviews Molecular Cell Biology 10th Anniversary

Hahn Lab - Research with biosensors and photoactivatable proteins highlighted in the 10th Anniversary Issue of Nature Reviews Molecular Cell Biology October 2010, 11(10): 680.

"Sensing and Controlling Protein Dyanmics" by Katherine H. Wrighton. article

"The work of Klaus Hahn has transformed biosensors into major cell biological tools that have revealed new and important insights." ~Rick Horwitz, University of Virginia

dashed line
Hahn Lab Endeavors photo - 100

Hahn Lab - Research using the LOV protein to control the ability to move and activiate cells with light is highlighted in the Fall 2010 edition of Endeavors, UNC's Research and Creative Activity Magazine.

"Send in the Cells" by Susan Hardy article

Hahn Lab cell cinema movies of moving cells with light

dashed line
Cox-Der SmallGTPases Cover 2010

Cox and Der Labs - Small GTPases Cover  Vol 1, Issue 1, July-August, 2010

"Ras History: The Saga Continues." Small GTPases 1(1):2-27.

This is the first volume, first issue, first article, and first cover of Small GTPases journal. About the cover

Online Article

dashed line
Hahn Lab Nature Biotechnology - 100

Hahn Lab - Nature Biotechnology highlighted publication, June 27, 2010

"Engineered allosteric activation of kinases in living cells." Nature Biotechnology June 27, 2010 [epub before publication].
Online Article

Article in UNC School of Medicine news

dashed line
Johnson Lab JBC Cover 2010 - 100

Johnson Lab - Cover of Journal of Biological Chemistry, April 16, 2010

"Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype." J Biol Chem 285:11760-11764. Online Article

dashed line
Cox Molecular Cell Biol Cover 2010 - 100

Cox Lab - Cover of Molecular and Cellular Biology, Feb., 2010

Online cover image and description

Related article: "The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis." Mol Cell Biol 29(4): 1035-1049. Online Article

dashed line
McCarthy Lab Science

McCarthy Lab - Science publication, March 5, 2010

"Hippocampal Short- and Long-term Plasticity are not Modulated by Astrocyte Ca2+ Signaling." Science 327(5970): 1250-1254, 2010. Online Article in Science
Commentary in Science on paper
Nature's Highlighting of paper
Nature Review Neuroscience's Highlighting of paper

A link for free access to Science's online full text article can be found on the McCarthy faculty page under publications.

dashed line
Roth Lab - Nature - 2009

Roth Lab - Nature publication, Nov. 12, 2009

"Predicting new molecular targets for known drugs." Nature 462(7270):175-81, 2009. Online Article

dashed line
Cell Cover - 2009 - Polleux Lab

Polleux Lab - Cover of Cell, September 4, 2009

"The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis." Cell 138:990-1004. Online Article

dashed line
Nature image Hahn Lab 2009

Hahn Lab - Highlighted Nature publication - Published back to back in same issue with Nature paper listed below.

"Genetically-encoded photoactivatable Rac reveals spatiotemporal coordination of Rac and Rho during cell motility." Nature 461: 104-110, 2009. View movie of cell ruffles induced in a HeLa cell expressing PA-Rac1. See more supplemental moviesOnline Article

dashed line
Hahn-Johnson Labs Nature image

Hahn and Johnson Labs - Nature publication - Published back to back in same issue with Nature paper listed above.

"Coordination of Rho GTPase activities during cell protrusion." Nature, 461: 99-103, 2009. Onine Article

dashed line
Hahn Lab - Immunology Cover - Mar 2009

Hahn Lab - Cover of Immunology

"RhoA GTPase Activation by TLR2 and TLR3 Ligands: Connecting via Src to NF-B." Abstract

dashed line
Samulski Virology Cover March 2009 - 100

Samulski Lab - Cover of Virology

"Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus." Abstract

dashed line
Molecular Cell Cover - Harden Lab

Harden and Sondek Labs - Cover of Molecular Cell

"General and versatile autoinhibition of phospholipase C isozymes. " Abstract

dashed line
Samulski Lab Molecular Therapy Cover, June 2008

Samulski Lab - Cover of Molecular Therapy

"Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles" Abstract


dashed line
Siderovski Issue of CCHTS

David Siderovski and Francis Willard are Guest Editors for a two-issue set of papers in the journal Combinatorial Chemistry and High Throughput Screening describing "new technologies and new opportunities for screening compound libraries for modulators of GPCR signaling."

Their editorial introduction to the June 2008 issue can be read here.
dashed line
Samulski Lab cover of Virology

Samulski Lab - Cover of Virology

"Surface loop dynamics in adeno-associated virus capsid assembly." Abstract

dashed line
Zhang Lab  Cancer Cell Cover

Zhang Lab - Cover of Cancer Cell

"Targeted inactivation of Mdm2 E3 ubiquitin ligase activity in the mouse reveals novel mechanistic insights into p53 regulation." Abstract

dashed line
Samulski Lab Cover of Virology

Samulski Lab - Cover of Virology

"Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions." Abstract

dashed line
Richard Mailman's cover of Trends in Pharacological Sciences

Richard Mailman - Cover of Trends in Pharmacological Sciences

"GPCR functional selectivity has therapeutic impact" Abstract

dashed line
McCarthy Lab Neuron article figure

McCarthy Lab - Neuron publication

"Selective Stimulation of Astrocyte Calcium In Situ Does Not Affect Neuronal Excitatory Synaptic Activity" Abstract

dashed line
Oncogene cover

Gary Johnson is Guest Editor for the May 14, 2007 issue of Oncogene, along with DN Dhanasekaran. Oncogene issue

Their introduction to the issue is titled "MAPKs: function, regulation, role in cancer and therapeutic targeting." Article

Figure 1: "Integration of the MAPK pathway in the cellular response to environmental stimuli." Artwork by Betsy Clarke.

dashed line
Picture Perfect Proteins article in Endeavors

Siderovski Lab - Research on G-alpha proteins is highlighted in the Spring 2007 edition of Endeavors, UNC's Research and Creative Activity Magazine.

"Picture Perfect Proteins" by Molly Davis Article

Before and After Photo of protein-crystallization image stablized by the addition of a peptide, making the image crystal clear.

dashed line
Wang Lab's cover of Molecular Cell

Wang Lab - Cover of Molecular Cell

"General and specific functions of exonic splicing silencers in splicing control."Abstract

dashed line
Johnson Lab cover of JBC

Johnson Lab - Cover of Journal of Biological Chemistry

"MEKK4 is an effector of the embryonic TRAF4 for JNK activation." Abstract

dashed line
Parise Endeavors

Parise Lab - Research on sickle cell adhesion is highlighted in the Spring 2006 edition of Endeavors, UNC's Research and Creative Activity Magazine.

"Getting Past Stickiness" by Jan McColm Article

Photo of Leslie Parise, Julie Brittain and Sheritha Lee.

dashed line
Hahn Lab cover of Cytometry

Hahn Lab - Cover of Cytometry

"Functional Proteometrics for Cell Migration" Abstract

dashed line
Cox Lab Cover of Molecular Cell

Cox Lab - Cover of Molecular Cell

"PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-XL on Mitochondria and Induces Apoptosis" Abstract

dashed line
Hahn Lab Nature publication

Hahn Lab - Nature publication

"Spatiotemporal dynamics of RhoA activity in migrating cells" Abstract

dashed line
Nicholas Lab highlighted paper in Journal of Bacteriology

Nicholas Lab - Selected as the highlight paper in Journal of Bacteriology

"Porin-Mediated Antibiotic Resistance in Neisseria gonorrhoeae: Ion, Solute, and Antibiotic Permeation through PIB Proteins with penB Mutations" Abstract

dashed line
Parise Lab Cover of Journal of Cell Biology

Parise Lab - Cover of the Journal of Cell Biology

"Essential role of CIB1 in regulating PAK1 activation and cell migration" Abstract

dashed line
Sondek Lab cover of Structure

Sondek Lab - Cover of Structure

"Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis" Abstract