Alan M. Jones

Alan M. Jones

Professor

Department of Biology

Ph.D., Plant Biology
University of Illinois, Urbana

Curriculum Vitae [.pdf]

Department of Biology

Contact Information  ->>

Research Interests

  • Signal Perception and the Regulation of Growth and Development

Research Synopsis

The Jones lab is interested in heterotrimeric G protein-coupled signaling and uses genetic model systems to dissect signaling networks. The G-protein complex serves as the nexus between cell surface receptors and various downstream enzymes that ultimately alter cell behavior. Metazoans have a hopelessly complex repertoire of G-protein complexes and cell surface receptors so we turned to the reference plant, Arabidopsis thaliana, and the yeast, Saccharomyces cerevisiae, as our models because these two organisms have only two potential G protein complexes and few cell surface receptors. Their simplicity and the ability to genetically "knock out" or "knock up" the expression of genes in these organisms make them powerful tools. At present, we are most interested in novel signaling networks that are used for sensing sugars and other networks used to sense extracellular nucleotides. We work closely with several other labs in the Dept. of Pharmacology and use a variety of cell biology approaches, including sophisticated imaging techniques, 3-D protein structure analyses, forward and reverse genetic approaches, and biochemistries.

( Fig. 1 - Arabidopsis Thaliana, Fig. 2 - THF1 Plastid Localization r, Fig. 3 - Root hair movie )

Fig. 4 - Collage of localization and recycling

Publications

pubmed

Click above for PubMed publications.

Contact Information


Office Location:
317 Coker Hall

Mailing Address:
CB # 7365
UNC-CH School of Medicine
Chapel Hill, NC 27599-7365

Office Phone: 919-962-6932
Lab Phone:
Fax: 919-962-9672
alan_jones[at]unc.edu

 

 

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