Andrea Nackley

Andrea Nackley Neely

Assistant Professor

Center for Neurosensory Disorders
Dept. of Endodentics, School of Dentistry

Ph.D., Neuroscience and Behavior
University of Georgia

Biosketch [.pdf]

Nackley Lab Website

Contact Information  ->>

Research Interests

  • Pain Neurobiology and Genetics
  • Biomarkers for persistent pain conditions

Research Synopsis

Chronic pain is one of our nation’s most significant healthcare problems. Although our understanding of pain neurobiology has grown over the last several years, few new therapeutics have been developed. Thus, it is imperative that further research is conducted to better understand chronic pain; its causes, effects, and treatments. Recent studies conducted by our laboratory and others demonstrate that a great deal of individual variability exists in pain sensitivity and likelihood to develop chronic pain conditions. Furthermore, there is significant individual variability in the efficacy, tolerance, and side-effect profiles for conventional analgesics used to treat pain. Variability in experimental pain, the development of chronic pain conditions, and analgesic responsiveness is due to a combination of environmental and genetic factors.

My research objectives are to 1) identify and characterize signalling processes that drive persistent pain conditions, 2) evaluate the potential functionality of common genetic polymorphisms that interact with environmental events to produce persistent pain conditions, and 3) identify biological markers predictive for the development of persistent pain conditions, including the severity and duration of the disorder as well as optimal management strategies for different individuals. Thus, my lab integrates molecular genetics, animal models, and clinical epidemiologic measures to better understand the neurobiological processes underlying persistent pain as well as to identify unique markers for the diagnosis of clinical pain conditions in order to ultimately provide novel targets for the development of effective individualized pain therapeutics.


Click here for complete list of published works (NCBI bibliography).

Contact Information

Office Location:
Room 5506, Koury Oral Health Sciences Building

Mailing Address:
Center for Neurosensory Disorders
Koury Oral Health Sciences Building
385 South Columbia Street
Chapel Hill, NC 27599-7455

Office Phone: 919-537-3204
Lab Phone: 919-537-3339
Fax: 919-966-5339



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