Chancellor's Emin. Professor of Chemistry, UNC
William R. Kenan, Jr. Distinguished Professor
Department of Chemistry
Curriculum Vitae [.pdf]
- Polymer synthesis and characterization
- Top-down fabrication strategies for applications in nanomedicine
- Photovoltaics and new strategies for energy storage
The recent breakthroughs in the DeSimone laboratories using specifically-designed materials for imprint lithography have enabled an extremely versatile and flexible method for the direct fabrication and harvesting of monodisperse, shape-specific nano-biomaterials. The method, referred to as Particle Replication In Non-wetting Templates, or PRINT, allows for the fabrication of monodisperse particles with simultaneous control over structure (i.e. shape, size, composition) and function (i.e. cargo, surface structure). Unlike other particle fabrication techniques, PRINT is delicate and general enough to be compatible with a variety of important next-generation cancer therapeutic, detection and imaging agents, including various cargos (e.g. DNA, proteins, chemotherapy drugs, biosensor dyes, radio-markers, contrast agents), targeting ligands (e.g. antibodies, cell targeting peptides) and functional matrix materials (e.g. bioabsorbable polymers, stimuli responsive matrices, etc). PRINT particles are presently being designed to reach new understandings and therapies in cancer prevention, diagnosis and treatment. Early detection via targeted delivery of the imaging agent goes hand in hand with these new directions. Cellular targeting can be accomplished by attaching cell-specific ligands to the surface of the PRINT particle. Potential cell-specific ligands include the integrin receptor peptide (GRGDSP), melanocyte stimulating hormone, vasoactive intestional peptide, anti-Her2 mouse antibodies, cell-penetrating peptides, and a variety of vitamins. Once targeted with a cell specific ligand, the PRINT particle can be delivered and imaged at the desired site. In this respect, PRINT particles promise great potential, since it is possible to utilize the ability to specifically target, be shape and size-specific, possess tunable matrixes, as well as the ability to incorporate imaging contrast agents. The PRINT technology from the DeSimone lab is playing an integral part in the NIH PPG as well as the newly awarded Carolina Cancer Center of Nanotechnology Excellence Grants.
Click above for PubMed publications.
- Merkel, T.J., and DeSimone, M.M. (2011) Dodging Drug-resistant Cancer with diamonds. Science Translational Medicine 3: 1-3.
- Enlow, E.M., LUft, C., Napier, M.E., and DeSimone, J.M. (2011) Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings. Nanoletters, DOI: 10.1021/nl104117p.
- Wang, Y., Betts, D.E., Finlay, J.A., Brewer, L., Callow, M.E., Callow, J.A., Wendt, D.E., and DeSimone, J.M. (2011) Photocurable Amphiphilic Perfluoropolyether/Poly(ethylene gycol) Networks for Fouling-Release Coatings. Macromolecules, DOI: 10.1021/ma102271t.
- Wang, Y., Merkel, T., Chen, K., Fromen, C., Betts, D., and DeSimone, J.M. (2011) Generation of a Library of Particles Having Controlled Sizes and Shapes via the Mechanical Elongation of Master Templates. Langmuir 27(2): 524-528.
- Merkel, T.J., Jones, S.W., Herlihy, K.P., Kersey, F.R., Shields, A.R., Napier, M.E., Luft, J.C., Wu, H., Zamboini, W.C., Wang, A.Z., Bear, J.E., and DeSimone, J.M. (2011) Using Mechano-biological Mimicry of Red Blood Cells to Extend Circulation Times of Hydrogel Microparticles. PNAS 108(2): 586-591.
- Kim, J., Rolland, J.P., Carbonell, R., and DeSimone, J.M. (2010) Ultrathin Cross-Linked Perfluoropolyether Film Coatings from Liquid CO2 and Subsequent UV Curing. Chem. Mater. 22(8): 2411-2413.
- Parrott, M.C., Luft, J.C., Byrne, J.D., Fain, J.H., Napier, M.E., and DeSimone, J.M. (2010) Tunable Bi-functional Silyl Ether Cross-Linkers for the Design of Acid Sensitive Biomaterials. J. Am. Chem. Soc. 132(50): 17928-17932.
- Hu, Z., Pitet, L.M., Hillmyer, M.A., and DeSimone, J.M. (2010) High Modulus, Low Surface Energy, Photochemically Curable Materials. Macromolecules 43(24): 10397-10405.
- Galloway, A.L., Murphy, A., Rolland, J.P., Herlihy, K.P., Petros, R.A., Napier, M.E., and DeSimone, J.M. (2010) "Micromolding for the Fabrication of Biological Microarrays." in Biological Microarrays: Methods and Protocols, Springer Protocols: Methods in Molecular Biology; Editors Khademhosseini, A., Suh, K-Y., Zourob, M.; Humana Press: Springer: New York, p. 249-260.
- Brown, E., Zhang, H., Forman, N.A., Maynor, B.W., Betts, D.E., DeSimone, J.M., and Jaeger, H.M. (2010) Shear Thickening in Densely Packed Suspensions of Spheres and Rods Confined to Few Layers. Journal of Rheology 54: 1023-1046.
- Nunes, J., Ertas, M., Du, L., and DeSimone, J.M. (2010) Hierarchical Control of Polymer Composite Nano- and Micro-structure with Lithography. Chemistry of Materials 22(13): 4069-4075.
- Merkel, T.J., Herlilhy, K.P., Nunes, J., Orgel, R.M., Rolland, J.P., and DeSimone, J.M. (2010) Scalable, Shape-Specific, Top-Down, Fabrication Methods for the Synthesis of Engineered Colloidal Particles. Langmuir 26(16): 13086-13096.
- Wang, J., Petros, R.A., Napier, M.E., and DeSimone, J.M. (2010) The Complex Role of Multivalency in Nanoparticles Targeting the Tranferrin Receptor for Cancer Therapies. J. Am. Chem. Soc. 132(32): 11306-11313.
- Jeong, W., Napier, M., and DeSimone*, J. M. (2010) Challenging Nature’s Monopoly on the Creation of Well-defined Particles. Nanomedicine 5(4): 633-639.
- Nunes, J., Herlihy, K., Mair, L., Superfine, R., and DeSimone*, J. M. (2010) Multifunctional Shape and Size Specific Magneto-Polymer Composite Particles. Nanoletters 10(4): 1113-1119.
- Petros, R. A., and DeSimone*, J. M. (2010) Strategies in the Design of Nanoparticles for Therapeutic Applications. Nature Reviews Drug Discovery 9: 615-627.
- Williams, S.S., Retterer, S., Lopez, R., Ruiz, R., Samulski, E. T., and DeSimone*, J. M. (2010) High Resolution PFPE-based Molding Techniques for Nanofabrication of High Pattern Density Sub-20 nm Features: A Fundamental Materials Approach. Nano Letters 10(4): 1421-1428.
- Brown, E., Forman, N.A., Orellana, C. S., Zhang, H., Maynor, B. W., Betts, D. E., DeSimone, J. M., Jaeger, H. M. (2010) Generality of Shear Thickening in Dense Suspensions. Nature Materials 9: 220-224. Abstract
- Hampton, M. J., Templeton, J. L., DeSimone*, J. M. (2010) Direct Patterning of CdSe Quantum Dots into Sub-100 nm Structures. Langmuir 26 (5): 3012-3015. Abstract