Rudolph L. Juliano

Rudolph L.  Juliano

Boshamer Distinguished Professor
Department of Pharmacology

Assoc. Dean for Research & Graduate Education, Division of Molecular Pharmacy, School of Pharmacy

Ph.D., Biophysics
University of Rochester, NY

Biosketch [.pdf]

Juliano Lab Website
School of Pharmacy Division of Molecular Pharmacy
Carolina Center of Cancer Nanotechnology Excellence

Contact Information  ->>

Research Interests

  • Oligonucleotide-based therapeutics
  • Development of small molecules to enhance oligonucleotide therapeutics
  • Intracellular trafficking of antisense and siRNA oligonucleotides in cancer cells

Research Synopsis

Development of Small Molecules that Enhance the Delivery and the Pharmacological Effects of Oligonucleotides

A key impediment to oligonucleotide-based therapeutics is the difficulty in delivering these large, highly polar molecules to their sites of action in the cytosol or nucleus of tissue cells. While chemical modification of oligonucleotides and the utilization of various nanotechnology-based delivery approaches have been helpful, the delivery problem remains largely unresolved. We have taken an orthogonal approach to this problem and have developed small molecule compounds that enhance the functional delivery and pharmacological effectiveness of oligonucleotides by manipulating their intracellular trafficking.

Intracellular Trafficking of Antisense and siRNA Oligonucleotides in Cancer Cells

Antisense and siRNA oligonucleotides have great potential for cancer therapeutics.  However our ability to use these molecules effectively is limited by lack of detailed molecular understanding of their cellular uptake and intracellular trafficking. We are addressing these issues using a variety of pharmacological, molecular and imaging techniques in single cells, multi-cellular assemblies, and tumors in vivo. This integrated approach will provide a rich stream of novel information that will enhance and expedite the development of oligonucleotides as therapeutic agents in cancer.


Click here for Pubmed publications.

Contact Information

Office Location:
1072 Genetic Medicine

Mailing Address:
CB # 7362
UNC-CH School of Medicine
Chapel Hill, NC 27599-7362

Office Phone: 919-966-4383
Lab Phone: 919-966-4343
Fax: 919-966-5640



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