{"id":5,"date":"2017-06-21T15:13:49","date_gmt":"2017-06-21T15:13:49","guid":{"rendered":"https:\/\/med-template.sites.unc.edu\/home\/"},"modified":"2026-02-17T12:01:09","modified_gmt":"2026-02-17T17:01:09","slug":"home","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/","title":{"rendered":"Home"},"content":{"rendered":"
\n

 <\/p>\n

\"Shown<\/a><\/p>\n

Project 1<\/h3>\n

We are defining the role of DVL paralogs in mediating oncogenic signaling
\nand regulating\u00a0immune evasion in the tumor microenvironment.<\/p>\n

Project 2<\/h3>\n

We are defining the role that estrogen synthesis and signaling play in regulating
\nmalignant properties of cancers such as colorectal cancer.<\/p>\n

Project 3<\/h3>\n

We are elucidating the role of epigenetic regulators such as DNA methylation readers and histone
\nmodifying enzymes in mediating oncogenic signaling in breast and colorectal cancer.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Project 1 We are defining the role of DVL paralogs in mediating oncogenic signaling and regulating\u00a0immune evasion in the tumor microenvironment. Project 2 We are defining the role that estrogen synthesis and signaling play in regulating malignant properties of cancers such as colorectal cancer. Project 3 We are elucidating the role of epigenetic regulators … Read more<\/a><\/p>\n","protected":false},"author":1369,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/front-page.php","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-5","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nHome - Pruitt Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home - Pruitt Lab\" \/>\n<meta property=\"og:description\" content=\"  Project 1 We are defining the role of DVL paralogs in mediating oncogenic signaling and regulating\u00a0immune evasion in the tumor microenvironment. Project 2 We are defining the role that estrogen synthesis and signaling play in regulating malignant properties of cancers such as colorectal cancer. Project 3 We are elucidating the role of epigenetic regulators … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/\" \/>\n<meta property=\"og:site_name\" content=\"Pruitt Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-17T17:01:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1050\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/\",\"name\":\"Home - Pruitt Lab\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3-300x210.png\",\"datePublished\":\"2017-06-21T15:13:49+00:00\",\"dateModified\":\"2026-02-17T17:01:09+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3.png\",\"width\":1500,\"height\":1050,\"caption\":\"Shown are schematics of three core projects of the Pruitt lab.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/\",\"name\":\"Pruitt Lab\",\"description\":\"Department of Pharmacology\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Home - Pruitt Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/","og_locale":"en_US","og_type":"article","og_title":"Home - Pruitt Lab","og_description":"  Project 1 We are defining the role of DVL paralogs in mediating oncogenic signaling and regulating\u00a0immune evasion in the tumor microenvironment. Project 2 We are defining the role that estrogen synthesis and signaling play in regulating malignant properties of cancers such as colorectal cancer. Project 3 We are elucidating the role of epigenetic regulators … Read more","og_url":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/","og_site_name":"Pruitt Lab","article_modified_time":"2026-02-17T17:01:09+00:00","og_image":[{"width":1500,"height":1050,"url":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/","url":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/","name":"Home - Pruitt Lab","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3-300x210.png","datePublished":"2017-06-21T15:13:49+00:00","dateModified":"2026-02-17T17:01:09+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/pharm\/pruittlab\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#primaryimage","url":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3.png","contentUrl":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-content\/uploads\/sites\/1395\/2026\/02\/Pruitt_lab_homepage-1500-3.png","width":1500,"height":1050,"caption":"Shown are schematics of three core projects of the Pruitt lab."},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/"},{"@type":"ListItem","position":2,"name":"Home"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/#website","url":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/","name":"Pruitt Lab","description":"Department of Pharmacology","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/users\/1369"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":8,"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":2476,"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/pages\/5\/revisions\/2476"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/pruittlab\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}