{"id":2219,"date":"2015-09-10T17:37:50","date_gmt":"2015-09-10T21:37:50","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/sondeklab\/"},"modified":"2020-12-11T09:35:53","modified_gmt":"2020-12-11T14:35:53","slug":"sondeklab","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/","title":{"rendered":"Sondek Lab"},"content":{"rendered":"
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Welcome to the Sondek Lab<\/h1>\n<\/div>\n
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\n\"Sondek<\/div>\n
\n\"Last
\nLast (virtual) group meeting of 2020<\/div>\n<\/div>\n
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Structural Biology of Signal Transduction<\/h2>\n

Our laboratory studies signal transduction systems controlled by heterotrimeric G proteins as well as Ras-related GTPases. The superfamily of GTPases control numerous signaling cascades based upon the regulated binding, hydrolysis, and exchange of guanine nucleotides; GTP-bound GTPases are active in downstream signaling while those bound to GDP are inactive. Mutant GTPases with abnormal GDP\/GTP cycling are implicated in numerous human diseases, including cancer. It is our desire to better understand the regulation of heterotrimeric G proteins and Ras-related GTPases at the molecular level with the ultimate goal of using this information to design therapies to correct abnormal signaling mediated by these proteins and thereby treat associated pathologies.<\/p>\n\n\n\n
\"Annual<\/th>\n\"SOM<\/th>\n\"Lineberger<\/th>\n\"MolCellBiophys<\/th>\n\"Pew<\/th>\n\"DR<\/th>\n\"NatureReviews<\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Welcome to the Sondek Lab Structural Biology of Signal Transduction Our laboratory studies signal transduction systems controlled by heterotrimeric G proteins as well as Ras-related GTPases. The superfamily of GTPases control numerous signaling cascades based upon the regulated binding, hydrolysis, and exchange of guanine nucleotides; GTP-bound GTPases are active in downstream signaling while those bound … Read more<\/a><\/p>\n","protected":false},"author":22429,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2219","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/wp-json\/wp\/v2\/pages\/2219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/wp-json\/wp\/v2\/comments?post=2219"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/wp-json\/wp\/v2\/pages\/2219\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/sondeklab\/wp-json\/wp\/v2\/media?parent=2219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}