{"id":8014,"date":"2018-11-29T16:44:22","date_gmt":"2018-11-29T21:44:22","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8014"},"modified":"2026-04-20T16:33:27","modified_gmt":"2026-04-20T20:33:27","slug":"j-mauro-calabrese-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/j-mauro-calabrese-phd\/","title":{"rendered":"J. Mauro Calabrese, PhD"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11601\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png\" alt=\"\" width=\"300\" height=\"204\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-768x522.png 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-1024x696.png 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/h2>\n<h2>Research Interests<\/h2>\n<ul>\n<li>epigenetic control by long noncoding RNAs, genomics, stem cells, cancer, human genetic disorders<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>The Calabrese lab seeks to make fundamental discoveries in genomics that unlock new innovations in medicine and biotechnology. Our current focus is on understanding how non-catalytic RNAs (lncRNAs) regulate gene expression inside of the nucleus. For reasons that remain unclear, mammalian genomes are pervasively transcribed. However, evidence suggests that prior to export from the nucleus, RNA coordinates a multitude of gene regulatory events that are essential for normal human health and homeostasis. We are working to delineate the relationships between sequence, structure, and function in regulatory RNAs, as well as the mechanisms that regulatory RNAs employ to control molecular events within the context of the chromatin environment. Given the centrality of gene regulation in human health and disease, we expect that successful completion of our research objectives will lead to the discovery of etiologies and therapeutic opportunities in many settings.<\/p>\n<p>Motivated graduate students and post-doctoral fellows interested in joining the group are encouraged to contact Dr. Calabrese via email.<\/p>\n<h3><strong>Publications<\/strong><\/h3>\n<p><strong><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/j%20mauro.calabrese.1\/bibliography\/44735528\/public\/?sort=date&amp;direction=descending\" rel=\"noopener noreferrer\">View complete list of publications in NCBI library<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests epigenetic control by long noncoding RNAs, genomics, stem cells, cancer, human genetic disorders Research Synopsis The Calabrese lab seeks to make fundamental discoveries in genomics that unlock new innovations in medicine and biotechnology. Our current focus is on understanding how non-catalytic RNAs (lncRNAs) regulate gene expression inside of the nucleus. For reasons that &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/j-mauro-calabrese-phd\/\" aria-label=\"Read more about J. Mauro Calabrese, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":20091,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8014","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["J. Mauro Calabrese, PhD"],"_upd_reverse_display_name":["Calabrese"],"_upd_last_name":["Calabrese"],"_upd_first_name":["J. Mauro"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Professor and Director of Graduate Studies<\/strong>\r\n<span style=\"background-color: #007fae;color: #fff\">Accepting Rotation Students<\/span>\r\nResearch: Epigenetic control by long noncoding RNAs, genomics, stem cells, cancer, human genetic disorders\r\nOffice: 4093 GMB\r\nPhone: <a href=\"tel:9198433257\">(919) 843-3257<\/a> \/ <a href=\"tel:9198433171\">(919) 843-3171<\/a>\r\n<a href=\"https:\/\/www.med.unc.edu\/pharm\/calabreselab\/\" rel=\"noopener\">Lab Website<\/a>\r\n<a href=\"mailto:jmcalabr@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"jmcalabr@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-3257","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"120 Mason Farm Rd.","address-2":"4093 Genetic Medicine","campus-box":"CB # 7365","city":"Chapel Hill","state":"NC","zip":"27599-7365"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":3,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8014\/revisions"}],"predecessor-version":[{"id":25746,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8014\/revisions\/25746"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/20091"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}