{"id":8016,"date":"2018-11-29T16:47:43","date_gmt":"2018-11-29T21:47:43","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8016"},"modified":"2026-03-10T14:12:50","modified_gmt":"2026-03-10T18:12:50","slug":"henrik-dohlman-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/henrik-dohlman-phd\/","title":{"rendered":"Henrik Dohlman, PhD"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11601\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png\" alt=\"\" width=\"300\" height=\"204\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-768x522.png 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-1024x696.png 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/h2>\n<h2>Research Interests<\/h2>\n<ul>\n<li>Regulators of G protein Signaling<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<h3 class=\"p1\">Mechanisms of Cell Desensitization: Regulators of G protein Signaling.<\/h3>\n<p class=\"p2\">Research in the <a href=\"https:\/\/www.med.unc.edu\/pharm\/dohlmanlab\/research\">Dohlman Lab<\/a> is centered on\u00a0G proteins\u00a0and\u00a0G protein-coupled receptors\u00a0(GPCRs). GPCRs are the target of many pharmaceuticals, hormones and neurotransmitters, as well as most environmental signals. Generally speaking, persistent stimulation of G proteins lead to desensitization. Familiar examples\u00a0include desensitization to light, odors and chemical stimulants such as caffeine.<\/p>\n<p class=\"p2\">Receptors, G proteins, and effector MAP kinases are conserved in evolution and are even found in the simplest eukaryotes such as yeast.\u00a0Through large-scale genomics, proteomics and metabolomics analysis the lab has identified new mutants with altered signaling and desensitization properties. These are then characterized biochemically and biophysically using homologous proteins in humans. This approach led to the identification\u00a0in yeast of a family of desensitization factors called\u00a0RGS proteins\u00a0(Regulator of G protein signaling). Whereas GPCRs activate G proteins,\u00a0RGS proteins inactivate G proteins, by\u00a0accelerating their GTPase activity.<\/p>\n<p class=\"p2\">Thus, RGS proteins serve as the molecular &#8216;brakes&#8217; in cell signaling: they diminish our sensitivity to enviromental signals, neurotransmitters and\u00a0pharmaceuticals over time.<\/p>\n<p class=\"p2\">Building on the RGS work, the lab is currently investigating how nutritional and stress signals, and their consequent molecular processes (e.g. feedback phosphorylation, protein ubiquitination, intracellular pH changes) can limit activation of competing signaling pathways. Efforts in collaboration with Tim Elston&#8217;s group seek to construct computational models of constituent signaling networks and pathways. The long-term objective is to devise predictive models of signal transduction in more complex systems, and ultimately determine how specific stimuli or drugs will influence the signaling network, in addition to specific target enzymes or receptors.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/henrik.dohlman.1\/bibliography\/public\/\">View complete list of publications in NCBI bibliography<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Regulators of G protein Signaling Research Synopsis Mechanisms of Cell Desensitization: Regulators of G protein Signaling. Research in the Dohlman Lab is centered on\u00a0G proteins\u00a0and\u00a0G protein-coupled receptors\u00a0(GPCRs). GPCRs are the target of many pharmaceuticals, hormones and neurotransmitters, as well as most environmental signals. Generally speaking, persistent stimulation of G proteins lead to desensitization. &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/henrik-dohlman-phd\/\" aria-label=\"Read more about Henrik Dohlman, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":19989,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8016","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Henrik Dohlman, PhD "],"_upd_reverse_display_name":["Dohlman, Henrik"],"_upd_last_name":["Dohlman"],"_upd_first_name":["Henrik"],"_upd_sortorder_override":["on"],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Sanford Steelman Distinguished Professor and Chair of the Department of <\/strong><strong>Pharmacology<\/strong>\r\nResearch: Regulation of G proteins\r\nOffice: 4016 GMB\r\nPhone: <a href=\"tel:9198436894\">(919) 843-6894<\/a>\r\n<a href=\"https:\/\/www.med.unc.edu\/pharm\/dohlmanlab\/\" rel=\"noopener\">Lab Website<\/a>\r\n<a href=\"mailto:henrik_dohlman@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"henrik_dohlman@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-6894","phone_type":"Office Phone","phone_override":""},{"phone_text":"919-843-4836 (Lab)"}]],"_upd_address":[[{"address":{"address-1":"120 Mason Farm Rd.","address-2":"4016 Genetic Medicine","campus-box":"CB # 7365","city":"Chapel Hill","state":"NC","zip":"27599-7365"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":3,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8016\/revisions"}],"predecessor-version":[{"id":27641,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8016\/revisions\/27641"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/19989"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}