{"id":8044,"date":"2018-11-29T17:26:18","date_gmt":"2018-11-29T22:26:18","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8044"},"modified":"2025-06-12T16:40:16","modified_gmt":"2025-06-12T20:40:16","slug":"john-sondek-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/","title":{"rendered":"John Sondek, PhD"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11601\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png\" alt=\"\" width=\"300\" height=\"204\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-768x522.png 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-1024x696.png 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/h2>\n<h2>Research Interests<\/h2>\n<ul>\n<li>Rho GTPases<\/li>\n<li>Dbl-family RhoGEFs<\/li>\n<li>Phospholipase C isozymes<\/li>\n<li>Drug discovery<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>Our laboratory studies signal transduction systems controlled by heterotrimeric G proteins as well as Ras-related GTPases. The superfamily of GTPases control numerous signaling cascades based upon the regulated binding, hydrolysis, and exchange of guanine nucleotides; GTPases bound to GTP are active in downstream signaling while those bound to GDP are inactive. Mutant GTPases with abnormal GDP\/GTP cycling are implicated in numerous human diseases, including cancer. It is our desire to better understand the regulation of heterotrimeric G proteins and Ras-related GTPases at the molecular level with the ultimate goal of using this information to design therapies to correct abnormal signaling mediated by these proteins and thereby treat associated pathologies.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=sondek%20j[Author]\" rel=\"noopener noreferrer\">View complete list of publications in PubMed<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Rho GTPases Dbl-family RhoGEFs Phospholipase C isozymes Drug discovery Research Synopsis Our laboratory studies signal transduction systems controlled by heterotrimeric G proteins as well as Ras-related GTPases. The superfamily of GTPases control numerous signaling cascades based upon the regulated binding, hydrolysis, and exchange of guanine nucleotides; GTPases bound to GTP are active in &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/\" aria-label=\"Read more about John Sondek, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":3440,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8044","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>John Sondek, PhD | Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"John Sondek, PhD | Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Research Interests Rho GTPases Dbl-family RhoGEFs Phospholipase C isozymes Drug discovery Research Synopsis Our laboratory studies signal transduction systems controlled by heterotrimeric G proteins as well as Ras-related GTPases. The superfamily of GTPases control numerous signaling cascades based upon the regulated binding, hydrolysis, and exchange of guanine nucleotides; GTPases bound to GTP are active in &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-12T20:40:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/sondek5.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"130\" \/>\n\t<meta property=\"og:image:height\" content=\"150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/\",\"name\":\"John Sondek, PhD | Pharmacology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/sondek5.jpg\",\"datePublished\":\"2018-11-29T22:26:18+00:00\",\"dateModified\":\"2025-06-12T20:40:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/sondek5.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/sondek5.jpg\",\"width\":130,\"height\":150},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pharm\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"John Sondek, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"name\":\"UNC Pharmacology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pharm\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\",\"name\":\"UNC Department of Pharmacology\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"width\":488,\"height\":329,\"caption\":\"UNC Department of Pharmacology\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"John Sondek, PhD | Pharmacology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pharm\/directory\/john-sondek-phd\/","og_locale":"en_US","og_type":"article","og_title":"John Sondek, PhD | Pharmacology","og_description":"Research Interests Rho GTPases Dbl-family RhoGEFs Phospholipase C isozymes Drug discovery Research Synopsis Our laboratory studies signal transduction systems controlled by heterotrimeric G proteins as well as Ras-related GTPases. 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7365","city":"Chapel Hill","state":"NC","zip":"27599-7365"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8044\/revisions"}],"predecessor-version":[{"id":25324,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8044\/revisions\/25324"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/3440"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}