{"id":8411,"date":"2019-01-17T08:55:35","date_gmt":"2019-01-17T13:55:35","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8411"},"modified":"2025-06-12T14:42:48","modified_gmt":"2025-06-12T18:42:48","slug":"channing-der-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/","title":{"rendered":"Channing Der, PhD"},"content":{"rendered":"<h2>Research Interests<\/h2>\n<ul>\n<li>Ras oncogenes<\/li>\n<li>Rho family small GTPases<\/li>\n<li>protein kinases<\/li>\n<li>signal transduction<\/li>\n<li>target-based anti-cancer drug discovery<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>The broad goal of our research is to delineate the molecular basis of cancer to identify novel approaches for cancer treatment. One major focus of our studies is the study of the Ras oncoproteins, which are key regulators of signal transduction pathways that control normal cell growth and differentiation. Mutationally activated Ras proteins are found in 30% of all human cancers and are validated drivers of cancer cell growth, invasion, and metastasis. Our studies focus on neoplasms with high frequency RAS mutations &#8211; cancers of the pancreas, colon, lung and skin. We are evaluating how aberrant Ras proteins alter the regulation of metabolism, protein kinases and the phosphoproteome, and gene expression to promote oncogenesis. One facet of these studies involves a dissection of the complex signaling mechanisms that are deregulated by Ras in cancer cells, including the Raf-MEK-ERK mitogen-activated protein kinase and the PI3K-AKT-mTOR signaling cascades. Another major aspect of our studies involves the study of Ras-related proteins. The human Ras proteins are but a small branch of a larger superfamily of Ras-related GTPases. We focus on the Ras homologous (Rho) small GTPases (Rac1, RhoA), recently found mutated in human cancers. Our studies utilize patient tumor-derived xenografts (PDX) and PDX-derived cell lines, organoid cultures and mouse models of cancer. Finally, we apply chemical and genetic functional screens, gene expression, protein kinase activation and phosphoprotein profiling, to identify novel therapeutic strategies to block mutant RAS for cancer treatment.<\/p>\n<figure id=\"attachment_9276\" class=\"thumbnail wp-caption aligncenter\" style=\"width: 422px\"><a href=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/03\/RAS-heart.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9276\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/03\/RAS-heart-300x168.png\" alt=\"\" width=\"412\" height=\"231\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/03\/RAS-heart-300x168.png 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/03\/RAS-heart-768x431.png 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/03\/RAS-heart-1024x574.png 1024w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/03\/RAS-heart.png 1700w\" sizes=\"auto, (max-width: 412px) 100vw, 412px\" \/><\/a><figcaption class=\"caption wp-caption-text\"><strong>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 The Ras &#8220;heart&#8221;<\/strong><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h2>Publications<\/h2>\n<p><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/myncbi\/channing.der.1\/bibliography\/40525359\/public\/?sort=date&amp;direction=descending\" rel=\"noopener noreferrer\"><strong>View complete list of publications in NCBI library<\/strong><br \/>\n<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Ras oncogenes Rho family small GTPases protein kinases signal transduction target-based anti-cancer drug discovery Research Synopsis The broad goal of our research is to delineate the molecular basis of cancer to identify novel approaches for cancer treatment. One major focus of our studies is the study of the Ras oncoproteins, which are key &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/\" aria-label=\"Read more about Channing Der, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":3425,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8411","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Channing Der, PhD | Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Channing Der, PhD | Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Research Interests Ras oncogenes Rho family small GTPases protein kinases signal transduction target-based anti-cancer drug discovery Research Synopsis The broad goal of our research is to delineate the molecular basis of cancer to identify novel approaches for cancer treatment. One major focus of our studies is the study of the Ras oncoproteins, which are key &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-12T18:42:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/der.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"130\" \/>\n\t<meta property=\"og:image:height\" content=\"150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/\",\"name\":\"Channing Der, PhD | Pharmacology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/der.jpg\",\"datePublished\":\"2019-01-17T13:55:35+00:00\",\"dateModified\":\"2025-06-12T18:42:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/der.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/der.jpg\",\"width\":130,\"height\":150},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pharm\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Channing Der, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"name\":\"UNC Pharmacology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pharm\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\",\"name\":\"UNC Department of Pharmacology\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"width\":488,\"height\":329,\"caption\":\"UNC Department of Pharmacology\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Channing Der, PhD | Pharmacology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pharm\/directory\/channing-der-phd\/","og_locale":"en_US","og_type":"article","og_title":"Channing Der, PhD | Pharmacology","og_description":"Research Interests Ras oncogenes Rho family small GTPases protein kinases signal transduction target-based anti-cancer drug discovery Research Synopsis The broad goal of our research is to delineate the molecular basis of cancer to identify novel approaches for cancer treatment. 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signal transduction and oncogenesis\r\nOffice: 32-012 LCCC\r\nPhone: <a href=\"tel:9199665634\">(919) 966-5634<\/a>\r\n<a href=\"http:\/\/cancer.med.unc.edu\/derlab\/\" rel=\"noopener\">Lab Website<\/a>\r\n<a href=\"mailto:cjder@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"cjder@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-966-5634","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"Lineberger Comprehensive Cancer Center","address-2":"450 West Drive, Room 32-012","campus-box":"CD #7295","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8411\/revisions"}],"predecessor-version":[{"id":25293,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8411\/revisions\/25293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/3425"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}