{"id":8426,"date":"2019-01-17T09:46:13","date_gmt":"2019-01-17T14:46:13","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8426"},"modified":"2025-06-12T15:24:42","modified_gmt":"2025-06-12T19:24:42","slug":"thomas-kash-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/","title":{"rendered":"Thomas Kash, PhD"},"content":{"rendered":"<h2>Research Interests<\/h2>\n<ul>\n<li>Synaptic Transmission and Plasticity<\/li>\n<li>Identification of neuronal substrates that underlie alcohol and drug abuse induced behaviors<\/li>\n<li>Determining the impact of stress on neuronal circuitry important for emotional behavior<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain.\u00a0 There is strong evidence for the existence of both endogenous stress and anti-stress systems.\u00a0 Chronic exposure to drugs of abuse and stress are hypothesized to modulate the relative balance of activity of these systems within key circuitry in the brain leading to dysregulated emotional behavior.\u00a0 One of the primary focuses of the Kash lab is to understand how chronic drugs of abuse and stress alter neuronal function, focusing on these stress and anti-stress systems in brain circuitry important for anxiety-like behavior.\u00a0 In particular, we are interested in defining alterations in synaptic function, modulation and plasticity using a combination of whole-cell patch-clamp physiology, biochemistry and mouse models.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?Db=pubmed&amp;Cmd=DetailsSearch&amp;Term=kash+tl%5BAuthor%5D\" rel=\"noopener noreferrer\">View complete list of publications in Pubmed<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Synaptic Transmission and Plasticity Identification of neuronal substrates that underlie alcohol and drug abuse induced behaviors Determining the impact of stress on neuronal circuitry important for emotional behavior Research Synopsis Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain.\u00a0 There is strong &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/\" aria-label=\"Read more about Thomas Kash, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":3433,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8426","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Thomas Kash, PhD | Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thomas Kash, PhD | Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Research Interests Synaptic Transmission and Plasticity Identification of neuronal substrates that underlie alcohol and drug abuse induced behaviors Determining the impact of stress on neuronal circuitry important for emotional behavior Research Synopsis Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain.\u00a0 There is strong &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-12T19:24:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/kash2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"130\" \/>\n\t<meta property=\"og:image:height\" content=\"150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/\",\"name\":\"Thomas Kash, PhD | Pharmacology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/kash2.jpg\",\"datePublished\":\"2019-01-17T14:46:13+00:00\",\"dateModified\":\"2025-06-12T19:24:42+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/kash2.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/kash2.jpg\",\"width\":130,\"height\":150,\"caption\":\"Dr. Tom Kash\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pharm\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Thomas Kash, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"name\":\"UNC Pharmacology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pharm\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\",\"name\":\"UNC Department of Pharmacology\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"width\":488,\"height\":329,\"caption\":\"UNC Department of Pharmacology\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Thomas Kash, PhD | Pharmacology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pharm\/directory\/thomas-kash-phd\/","og_locale":"en_US","og_type":"article","og_title":"Thomas Kash, PhD | Pharmacology","og_description":"Research Interests Synaptic Transmission and Plasticity Identification of neuronal substrates that underlie alcohol and drug abuse induced behaviors Determining the impact of stress on neuronal circuitry important for emotional behavior Research Synopsis Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain.\u00a0 There is strong &hellip; 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Andrews Distinguished Professor and Director, Bowles Center for Alcohol Studies<\/strong>\r\nResearch: Neurophysiological alterations underlying dysregulated emotional behavior\r\nPhone: <a href=\"tel:9199667116\">(919) 966-7116<\/a>\r\n<a href=\"http:\/\/www.kash-lab.org\/\" rel=\"noopener\">Lab Website<\/a>\r\n<a href=\"mailto:tkash@email.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"tkash@email.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-966-7116","phone_type":"Office Phone"}]],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8426\/revisions"}],"predecessor-version":[{"id":25302,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8426\/revisions\/25302"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/3433"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}