{"id":8455,"date":"2019-01-17T10:54:14","date_gmt":"2019-01-17T15:54:14","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8455"},"modified":"2025-06-17T17:16:45","modified_gmt":"2025-06-17T21:16:45","slug":"jeanette-gowen-cook-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/jeanette-gowen-cook-phd\/","title":{"rendered":"Jeanette Gowen Cook, PhD"},"content":{"rendered":"<h3><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-11601 alignnone\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png\" alt=\"\" width=\"300\" height=\"204\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-768x522.png 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-1024x696.png 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/h3>\n<h2>Research Interests<\/h2>\n<ul>\n<li><i>Cell Cycle Control in Human Cells<\/i><\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>Our lab studies the regulation of the mammalian cell cycle with a\u00a0particular focus on the cell\u00a0cycle phase transitions\u00a0related to DNA replication and\u00a0to cell cycle exit. \u00a0Cells coordinate progression through the cell division cycle with a wide variety of extracellular and intracellular information by regulating the activity and abundance of key cell cycle proteins.\u00a0\u00a0Many proteins have more than one function in the cell cycle, and one of our goals is to understand how those different functions are integrated to ensure normal cell proliferation and genome stability.<\/p>\n<p>We manipulate cell cycle proteins in human cell lines using a variety of molecular genetic tools. We deplete proteins from cells using siRNA techniques, overproduce proteins using recombinant plasmid or viral vectors, and inhibit activities with pharmacological reagents. New projects employ live cell imaging and quantitative single cell analysis of protein abundance during the cell cycle. Ultimately we hope to achieve a greater understanding of normal cell cycle control so that future therapeutic tools related to regeneration and cancer treatment can be developed.<\/p>\n<div>\n<p>For more detailed information, as well as an introduction to the members of the Cook lab, visit our webpage:\u00a0<strong><a class=\"external-link\" title=\"\" href=\"https:\/\/sites.google.com\/site\/cooklabgroup\/home\" rel=\"noopener noreferrer\">https:\/\/sites.google.com\/site\/cooklabgroup\/home<\/a><\/strong><\/p>\n<p>Core Techniques:<\/p>\n<ul>\n<li>human cell culture<\/li>\n<li>live cell imaging<\/li>\n<li>RNAi<\/li>\n<li>protein-protein and protein-chromatin interactions<\/li>\n<li>recombinant DNA technology<\/li>\n<\/ul>\n<\/div>\n<h2>Publications<\/h2>\n<p><strong><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/jeanette.cook.1\/bibliograpahy\/40322918\/public\/?sort=date&amp;direction=descending\" rel=\"noopener noreferrer\">View complete list of publications in NCBI library<\/a><\/strong><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=PureSearch&amp;db=PubMed&amp;details_term=cook%20jg%20AND%20(dna%20OR%20kinase)\" target=\"_blank\" rel=\"noopener noreferrer\"><br \/>\n<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Cell Cycle Control in Human Cells Research Synopsis Our lab studies the regulation of the mammalian cell cycle with a\u00a0particular focus on the cell\u00a0cycle phase transitions\u00a0related to DNA replication and\u00a0to cell cycle exit. \u00a0Cells coordinate progression through the cell division cycle with a wide variety of extracellular and intracellular information by regulating the &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/jeanette-gowen-cook-phd\/\" aria-label=\"Read more about Jeanette Gowen Cook, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":11585,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8455","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Jeanette Gowen Cook, PhD"],"_upd_reverse_display_name":["Cook, Jeanette"],"_upd_last_name":["Cook"],"_upd_first_name":["Jeanette"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Professor &amp; Chair of\r\nBiochemistry &amp; Biophysics<\/strong>\r\n<span style=\"background-color: #007fae;color: #fff\">Accepting Rotation Students<\/span>\r\nResearch: Cell Cycle Control in Human Cells\r\nOffice: 3062 GMB\r\nPhone: <a href=\"tel:9198433867\">(919) 843-3867<\/a>\r\n<a href=\"https:\/\/sites.google.com\/site\/cooklabgroup\/home\" rel=\"noopener\">Lab Website<\/a>\r\n<a href=\"mailto:jean_cook@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"jean_cook@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-3867"}]],"_upd_address":[[{"address":{"address-1":"120 Mason Farm Rd.","address-2":"3062 Genetic Medicine","campus-box":"CB #7260","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":2,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8455\/revisions"}],"predecessor-version":[{"id":25394,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8455\/revisions\/25394"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/11585"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}