{"id":8488,"date":"2019-01-17T12:39:20","date_gmt":"2019-01-17T17:39:20","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8488"},"modified":"2024-10-15T11:52:36","modified_gmt":"2024-10-15T15:52:36","slug":"t-kendall-harden-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/","title":{"rendered":"T. Kendall Harden, PhD"},"content":{"rendered":"<h3>Research Interests<\/h3>\n<ul>\n<li>Phospholipase C and inositol lipid signaling<\/li>\n<li>P2Y receptors for extracellular nucleotides<\/li>\n<li>G proteins<\/li>\n<\/ul>\n<h3>Research Synopsis<\/h3>\n<p>The physiological responses of many hormones, neurotransmitters, growth factors, and other extracellular stimuli are mediated through phospholipase C (PLC)-catalyzed hydrolysis of membrane phosphoinositides.\u00a0 \u00a0A long-term goal of our research is to delineate the molecular mechanisms whereby PLC activity is modulated by receptor-activated heterotrimeric and Ras superfamily G proteins, as well as by tyrosine phosphorylation.\u00a0 This work focuses on three PLC isozymes:\u00a0(1) PLC-\u03b2 isozymes, which are the prototypical heterotrimeric G protein-regulated PLCs, (2) PLC-\u03b5, which is uniquely directly activated by both Rho and Ras GTPases acting through independent domains, and (3) PLC-\u03b3 isozymes, which are activated by phosphorylation by receptor and non-receptor tyrosine kinases.<\/p>\n<p>Our research also focuses on mechanistic and pharmacological aspects of a class of G protein-coupled receptors (the eight member P2Y receptor family) that are activated by extracellular nucleotides.<\/p>\n<h3>Publications<\/h3>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?cmd=search&amp;db=pubmed&amp;term=Harden+TK+[au]\" target=\"_blank\" rel=\"noopener noreferrer\"><i>Click here for a complete list of his publications (PubMed)<\/i><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Phospholipase C and inositol lipid signaling P2Y receptors for extracellular nucleotides G proteins Research Synopsis The physiological responses of many hormones, neurotransmitters, growth factors, and other extracellular stimuli are mediated through phospholipase C (PLC)-catalyzed hydrolysis of membrane phosphoinositides.\u00a0 \u00a0A long-term goal of our research is to delineate the molecular mechanisms whereby PLC activity &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/\" aria-label=\"Read more about T. Kendall Harden, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":3478,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8488","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["T. Kendall Harden, PhD"],"_upd_reverse_display_name":["Harden, Kendall"],"_upd_last_name":["Harden"],"_upd_first_name":["T. Kendall"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Kenan Distinguished Professor Emeritus<\/strong>\r\nResearch: G protein-mediated signaling\r\n<a href=\"mailto:tkh@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"tkh@med.unc.edu"}]],"_upd_phone":[],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8488\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/3478"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}