{"id":8522,"date":"2019-01-17T13:45:38","date_gmt":"2019-01-17T18:45:38","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8522"},"modified":"2025-06-17T17:26:35","modified_gmt":"2025-06-17T21:26:35","slug":"clyde-hodge-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/clyde-hodge-phd\/","title":{"rendered":"Clyde Hodge, PhD"},"content":{"rendered":"<h2>Research Interests<\/h2>\n<ul>\n<li>Discover the neural circuits and molecular mechanisms that mediate the reinforcing and pleasurable subjective effects of alcohol and other drugs<\/li>\n<li>Identify the long-term effects of cocaine and alcohol abuse during adolescence<\/li>\n<li>Identify novel neural targets and validate pharmacological compounds that may be used to treat problems associated with alcohol and drug abuse<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p align=\"justify\">Our studies have shown that the limbic system and extended amygdala regulate alcohol-seeking behavior and conditioned discriminative stimulus effects of alcohol. We established that neuropeptide-Y in the hypothalamus modulates excessive alcohol drinking similar to its role in obesity via the Y1 receptor, and that NPY-Y5 receptor blockade reduces the reinforcing effects of alcohol. Also, using gene knockout mice, we have shown that Protein Kinase C-\u03b5 regulates alcohol drinking, reinforcement, sensitivity, withdrawal, and mesolimbic dopamine release through enhancement of GABA-A receptor function. Other studies have shown that adolescent exposure to cocaine leads to enhanced vulnerability to the rewarding effects of cocaine during adulthood in mice via activation of the limbic system.<\/p>\n<h2>Publications<\/h2>\n<p><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?cmd=search&amp;db=pubmed&amp;term=Hodge+Clyde+[au]\" rel=\"noopener\"><strong>View complete list of publications in Pubmed<\/strong><br \/>\n<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Discover the neural circuits and molecular mechanisms that mediate the reinforcing and pleasurable subjective effects of alcohol and other drugs Identify the long-term effects of cocaine and alcohol abuse during adolescence Identify novel neural targets and validate pharmacological compounds that may be used to treat problems associated with alcohol and drug abuse Research &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/clyde-hodge-phd\/\" aria-label=\"Read more about Clyde Hodge, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":18455,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8522","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Clyde Hodge, PhD"],"_upd_reverse_display_name":["Hodge, Clyde"],"_upd_last_name":["Hodge"],"_upd_first_name":["Clyde"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Professor\r\nPsychiatry<\/strong>\r\nResearch: Molecular mechanisms mediating the reinforcing\/pleasurable subjective effects of alcohol &amp; other drugs\r\nOffice: 1025A Thurston Bowles\r\nPhone: <a href=\"tel:9198434823\">(919) 843-4823<\/a>\r\n<a href=\"https:\/\/hodgelab.web.unc.edu\/\">Lab Website<\/a>\r\n<a href=\"mailto:chodge@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"chodge@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-4823","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"1025A Thurston Bowles Bldg.","address-2":"","campus-box":"CB #7178","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":2,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8522\/revisions"}],"predecessor-version":[{"id":25403,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8522\/revisions\/25403"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/18455"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}