{"id":8565,"date":"2019-01-17T14:44:32","date_gmt":"2019-01-17T19:44:32","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8565"},"modified":"2025-08-04T13:24:31","modified_gmt":"2025-08-04T17:24:31","slug":"yanping-zhang-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/","title":{"rendered":"Yanping Zhang, PhD"},"content":{"rendered":"<h2>Research Interests<\/h2>\n<ul>\n<li>Genetics and molecular mechanisms of cancer<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p class=\" \">My lab studies the function and regulation of the Mdm2-p53 tumor suppression pathway<\/p>\n<h3 class=\" \">In vivo\u00a0function of Mdm2 E3 ubiquitin ligase\u00a0in p53 regulation<\/h3>\n<p class=\" \"><b><\/b>The tumor suppressor p53 is a critical mediator of the cellular stress response, maintaining genomic integrity and preventing oncogenic transformation. Mdm2, the primary negative regulator for p53, controls p53 through functioning as an E3 ubiquitin ligase targeting p53 for proteasomal degradation. Our recent studies with mouse models expressing knock-in mutant Mdm2 have revealed a surprisingly dispensable nature for the Mdm2 E3 ligase under unstressed conditions. We are interested in defining the function of Mdm2 in p53 regulation, thereby providing insight into the Mdm2-p53 regulatory loop and solutions to the current problems surrounding the development of effective cancer therapeutics targeting the p53 pathway.<\/p>\n<h3 class=\" \">The ribosomal protein-Mdm2-p53 signaling pathway in energy metabolism and cancer prevention<\/h3>\n<p class=\"DataField11pt-Single\">Cellular growth and division are two fundamental processes that are exquisitely sensitive and responsive to environmental fluctuations. One of the most energetically demanding functions of these processes is ribosome biogenesis, a key component to regulating overall protein synthesis and cell growth. Our previous studies have established the RP-Mdm2-p53 signaling pathway that is critical in glucose tolerance and energy homeostasis. We are interested in delineating the function and mechanism of this pathway in preventing oncogenic induced tumorigenesis and dietary induced obesity and diabetes.<\/p>\n<h3 class=\" \">Multifaceted mitochondrial p32 in the regulation of apoptotic cell death<\/h3>\n<p class=\" \"><b><\/b>Apoptosis is a tightly regulated form of programmed cell death that is critical for proper embryonic development, tissue homeostasis and immune response, and aberrant regulation of this process contributes to autoimmune disorders, neurodegenerative disease and cancer. We have previously identified mitochondrial protein p32 as a critical mediator of p53\u2019s apoptotic function. We are interested in characterizing the role of p32 in coordinating mitochondrial metabolism with apoptotic cell death, and exploring the potential of p32 as a therapeutic target for the treatment of cancers.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/yanping.zhang.1\/bibliography\/40651128\/public\/?sort=date&amp;direction=descending\" rel=\"noopener noreferrer\">View complete list of publications in NCBI library<\/a><\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Genetics and molecular mechanisms of cancer Research Synopsis My lab studies the function and regulation of the Mdm2-p53 tumor suppression pathway In vivo\u00a0function of Mdm2 E3 ubiquitin ligase\u00a0in p53 regulation The tumor suppressor p53 is a critical mediator of the cellular stress response, maintaining genomic integrity and preventing oncogenic transformation. Mdm2, the primary &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/\" aria-label=\"Read more about Yanping Zhang, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":3376,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8565","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Yanping Zhang, PhD | Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yanping Zhang, PhD | Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Research Interests Genetics and molecular mechanisms of cancer Research Synopsis My lab studies the function and regulation of the Mdm2-p53 tumor suppression pathway In vivo\u00a0function of Mdm2 E3 ubiquitin ligase\u00a0in p53 regulation The tumor suppressor p53 is a critical mediator of the cellular stress response, maintaining genomic integrity and preventing oncogenic transformation. Mdm2, the primary &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-04T17:24:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"130\" \/>\n\t<meta property=\"og:image:height\" content=\"150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/\",\"name\":\"Yanping Zhang, PhD | Pharmacology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg\",\"datePublished\":\"2019-01-17T19:44:32+00:00\",\"dateModified\":\"2025-08-04T17:24:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg\",\"width\":130,\"height\":150,\"caption\":\"Dr. YanPing Zhang, PhD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pharm\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Yanping Zhang, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"name\":\"UNC Pharmacology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pharm\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#organization\",\"name\":\"UNC Department of Pharmacology\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png\",\"width\":488,\"height\":329,\"caption\":\"UNC Department of Pharmacology\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Yanping Zhang, PhD | Pharmacology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/","og_locale":"en_US","og_type":"article","og_title":"Yanping Zhang, PhD | Pharmacology","og_description":"Research Interests Genetics and molecular mechanisms of cancer Research Synopsis My lab studies the function and regulation of the Mdm2-p53 tumor suppression pathway In vivo\u00a0function of Mdm2 E3 ubiquitin ligase\u00a0in p53 regulation The tumor suppressor p53 is a critical mediator of the cellular stress response, maintaining genomic integrity and preventing oncogenic transformation. Mdm2, the primary &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/","og_site_name":"Pharmacology","article_publisher":"https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/","article_modified_time":"2025-08-04T17:24:31+00:00","og_image":[{"width":130,"height":150,"url":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/","url":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/","name":"Yanping Zhang, PhD | Pharmacology","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/pharm\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg","datePublished":"2019-01-17T19:44:32+00:00","dateModified":"2025-08-04T17:24:31+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg","contentUrl":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/zhang2.jpg","width":130,"height":150,"caption":"Dr. YanPing Zhang, PhD"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/pharm\/directory\/yanping-zhang-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/pharm\/"},{"@type":"ListItem","position":2,"name":"Yanping Zhang, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/pharm\/#website","url":"https:\/\/www.med.unc.edu\/pharm\/","name":"UNC Pharmacology","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/pharm\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/pharm\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/pharm\/#organization","name":"UNC Department of Pharmacology","url":"https:\/\/www.med.unc.edu\/pharm\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/Pharmacology_logo_2c_rgb_v.png","width":488,"height":329,"caption":"UNC Department of Pharmacology"},"image":{"@id":"https:\/\/www.med.unc.edu\/pharm\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/UNC-Pharmacology-693103474191364\/"]}]}},"_upd_display_name":["Yanping Zhang, PhD"],"_upd_reverse_display_name":["Zhang, Yanping"],"_upd_last_name":["Zhang"],"_upd_first_name":["Yanping"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Professor Emeritus<\/strong>\r\nResearch: Molecular basis of cancer\r\n<a href=\"mailto:ypzhang@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"ypzhang@med.unc.edu"}]],"_upd_phone":[],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":2,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8565\/revisions"}],"predecessor-version":[{"id":25750,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8565\/revisions\/25750"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/3376"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}