{"id":8574,"date":"2019-01-18T07:29:10","date_gmt":"2019-01-18T12:29:10","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8574"},"modified":"2024-10-15T11:59:31","modified_gmt":"2024-10-15T15:59:31","slug":"alan-m-jones-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/alan-m-jones-phd\/","title":{"rendered":"Alan M. Jones, PhD"},"content":{"rendered":"<h2>Research Interests<\/h2>\n<ul>\n<li>Signal Perception and the Regulation of Growth and Development<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>The Jones lab is interested in heterotrimeric G protein-coupled signaling and uses genetic model systems to dissect signaling networks. The G-protein complex serves as the nexus between cell surface receptors and various downstream enzymes that ultimately alter cell behavior. Metazoans have a hopelessly complex repertoire of G-protein complexes and cell surface receptors so we turned to the reference plant,\u00a0<i>Arabidopsis thaliana<\/i>, and the yeast,\u00a0<i>Saccharomyces cerevisiae<\/i>, as our models because these two organisms have only two potential G protein complexes and few cell surface receptors. Their simplicity and the ability to genetically &#8220;knock out&#8221; or &#8220;knock up&#8221; the expression of genes in these organisms make them powerful tools. At present, we are most interested in novel signaling networks that are used for sensing sugars and other networks used to sense extracellular nucleotides. Our work shows the great plasticity of the activation mechanism in eukaryotic cells. \u00a0We work closely with several other labs in the Dept. of Pharmacology and use a variety of cell biology approaches, including sophisticated imaging techniques, 3-D protein structure analyses, forward and reverse genetic approaches, biochemistries, and mathematical modeling.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?cmd=search&amp;db=pubmed&amp;term=arabidopsis[MESH+Terms]+OR+plant*[text+word]+AND+Jones+AM+[au]\" rel=\"noopener noreferrer\">View complete list of publications in Pubmed<\/a><\/strong><\/p>\n<p>Fig. 1 &#8211; <i>Arabidopsis Thaliana<\/i>, Fig. 2 &#8211;\u00a0<i>THF1 Plastid Localization r,<\/i> Fig. 3\u00a0 &#8211; Collage of localization and recycling<\/p>\n<figure id=\"attachment_4314\" class=\"thumbnail wp-caption alignnone\" style=\"width: 185px\"><a href=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/jones-arabidopsisThaliana_WS.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4314 size-full\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/jones-arabidopsisThaliana_WS.jpg\" alt=\"A top view of an Arabidopsis Thailiana plant with green leaves in a container.\" width=\"175\" height=\"205\" \/><\/a><figcaption class=\"caption wp-caption-text\">Fig. 1: Arabidopsis Thaliana<\/figcaption><\/figure>\n<figure id=\"attachment_4318\" class=\"thumbnail wp-caption alignnone\" style=\"width: 310px\"><a href=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/jones-thf1_plastid_localization_r-500.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4318 size-medium\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/jones-thf1_plastid_localization_r-500-300x268.jpg\" alt=\"A slide of a narrow finger-shaped cell with green spots along the interior of the cell membrane \" width=\"300\" height=\"268\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/jones-thf1_plastid_localization_r-500-300x268.jpg 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/jones-thf1_plastid_localization_r-500.jpg 500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Fig. 2: Thf1 plastid localization r<\/figcaption><\/figure>\n<div class=\"mceTemp\"><\/div>\n<figure id=\"attachment_4316\" class=\"thumbnail wp-caption alignnone\" style=\"width: 310px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4316 size-medium\" style=\"font-weight: bold\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/collage-of-localization-and-recycling-300x279.jpg\" alt=\"Red protein blobs in a green circle surround a yellow and blue nucleus with an overlay of 3 pink recycling arrows in a circle.\" width=\"300\" height=\"279\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/collage-of-localization-and-recycling-300x279.jpg 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/collage-of-localization-and-recycling.jpg 464w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"caption wp-caption-text\">Fig. 3: Collage of localization and recycling<\/figcaption><\/figure>\n<p>About Fig. 3: G protein-coupled signaling at the membrane is received by proteins located at many locations in the cell, including the nucleus. Cells regulate these connections by protein trafficking.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Signal Perception and the Regulation of Growth and Development Research Synopsis The Jones lab is interested in heterotrimeric G protein-coupled signaling and uses genetic model systems to dissect signaling networks. The G-protein complex serves as the nexus between cell surface receptors and various downstream enzymes that ultimately alter cell behavior. Metazoans have a &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/alan-m-jones-phd\/\" aria-label=\"Read more about Alan M. Jones, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":18463,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8574","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Alan M. Jones, PhD"],"_upd_reverse_display_name":["Jones, Alan"],"_upd_last_name":["Jones"],"_upd_first_name":["Alan"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Kenan Distinguished Professor Emeritus<\/strong>\r\nResearch: Signal Perception and the Regulation of Growth and Development\r\n<a href=\"mailto:alan_jones@unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"alan_jones@unc.edu"}]],"_upd_phone":[],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/8574\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/18463"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}