{"id":9286,"date":"2019-04-01T10:46:10","date_gmt":"2019-04-01T14:46:10","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=9286"},"modified":"2025-06-18T15:29:03","modified_gmt":"2025-06-18T19:29:03","slug":"maria-m-aleman-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/maria-m-aleman-phd\/","title":{"rendered":"Maria M. Aleman, PhD"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-11601\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png\" alt=\"\" width=\"300\" height=\"204\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-768x522.png 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-1024x696.png 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/h2>\n<h2>Research Interests<\/h2>\n<ul>\n<li>Blood and vascular biology<\/li>\n<li>Erythropoiesis<\/li>\n<li>Iron metabolism<\/li>\n<li>RNA regulation<\/li>\n<li>Coagulation<\/li>\n<li>Non-malignant hematology<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>The broad goal of our research is to understand basic mechanisms regulating erythropoiesis (red blood cell differentiation and maturation). Erythropoiesis begins in the bone marrow where hematopoietic stem cells differentiate through multiple stages of multipotent progenitor cells until ultimately committing to the erythroid lineage. Subsequent differentiation down this track involves coordinated gene expression, including RNA regulation, and accumulation of iron for heme biosynthesis and hemoglobin production.\u00a0 Our current work focuses on a family of dual functional proteins (poly C binding proteins) which both regulate RNA processing and chaperone iron within cells. Using biochemical, cellular, and in vivo models we explore the cross talk between iron trafficking and RNA regulation mediated by poly C binding proteins and how these activities are modulated by disease.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/maria%20m..aleman.1\/bibliography\/public\/\">View complete list of publications in NCBI library<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Blood and vascular biology Erythropoiesis Iron metabolism RNA regulation Coagulation Non-malignant hematology Research Synopsis The broad goal of our research is to understand basic mechanisms regulating erythropoiesis (red blood cell differentiation and maturation). Erythropoiesis begins in the bone marrow where hematopoietic stem cells differentiate through multiple stages of multipotent progenitor cells until ultimately &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/maria-m-aleman-phd\/\" aria-label=\"Read more about Maria M. Aleman, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":20236,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-9286","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Maria M. Aleman, PhD"],"_upd_reverse_display_name":["Aleman, Maria M."],"_upd_last_name":["Aleman"],"_upd_first_name":["Maria M."],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Assistant Professor\r\n<\/strong>Research: Non-malignant hematology with a focus on erythropoiesis, RNA regulation, and iron metabolism\r\nOffice: 4092 GMB\r\nPhone: <a href=\"tel:9199666375\">(919) 966-6375<\/a>\r\n<a href=\"https:\/\/tarheels.live\/alemanlab\/\" rel=\"noopener\">Lab Website<\/a>\r\n<a class=\"mail-link\" href=\"mailto:mmaleman@email.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"mmaleman@email.unc.edu"}]],"_upd_phone":[[{"phone_text":"(919) 966-6375","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"120 Mason Farm Rd.","address-2":"4092 Genetic Medicine Bldg.","campus-box":"CB# 7365","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/9286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/9286\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/20236"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=9286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}