{"id":9308,"date":"2019-04-01T12:21:02","date_gmt":"2019-04-01T16:21:02","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=9308"},"modified":"2025-06-12T14:04:48","modified_gmt":"2025-06-12T18:04:48","slug":"leon-coleman-md-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/leon-coleman-md-phd\/","title":{"rendered":"Leon Coleman, MD, PhD"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11601 size-medium\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png\" alt=\"\" width=\"300\" height=\"204\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-300x204.png 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-768x522.png 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2019\/01\/OGE-Trained-mentor-badge-webCR2-1024x696.png 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/h2>\n<h2>Research Interests<\/h2>\n<ul>\n<li>Immune mechanisms in drug addiction and critical illness, neurodegeneration, extracellular vesicle signaling<\/li>\n<\/ul>\n<h2>Research Synopsis<\/h2>\n<p>The overriding goal of Dr. Coleman\u2019s work is to identify novel treatments for alcohol use disorders (AUD) and associated peripheral disease pathologies.\u00a0 Currently, this includes:<\/p>\n<h3>Neuroimmune Signaling in AUD<\/h3>\n<p>The goal of this project is to determine the role of innate immune induction in the pathology of AUD across the lifespan.\u00a0 This project examines the overall hypothesis that chronic ethanol induces innate immune signaling via Toll-like Receptors and cytokines, contributing to neurotoxicity and behavioral phenotypes associated with AUD.\u00a0 Specific immune pathways are assessed for their involvement in models of chronic alcohol abuse and postmortem human alcoholic brain.<\/p>\n<h3>Alcohol-associated Immune Dysfunction in Associated Disease States<\/h3>\n<p>Alcohol abuse causes altered central and peripheral immune function, which can contribute to worsened outcomes in the setting of systemic inflammation and increased risk for other diseases.\u00a0 The goal of this project is to determine the contribution of alcohol-induced immune dysfunction to the pathology other disease states that may be associated with alcohol and other substance abuse such as Alzheimer\u2019s disease, sepsis, and cancer. \u00a0We hope to identify common pathways associated with alcohol and\/or other substance abuse and these associated conditions that can be targeted for intervention to improve patient outcomes.<\/p>\n<h3>Extracellular Vesicles as key signaling mediators<\/h3>\n<p>Extracellular vesicles (e.g. microvesicles and exosomes) are key components in extracellular fluid compartments and tissue extracellular matrices that can facilitate cell-cell communication.\u00a0 Dr. Coleman is interested in understanding the role of extracellular vesicle-mediated signaling in AUD and other systemic inflammatory disease states, and their potential use as biomarkers or vehicles for targeted drug delivery.<\/p>\n<h2>Publications<\/h2>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/leon.coleman.1\/bibliography\/public\/\" rel=\"noopener noreferrer\">View complete list of publications in NCBI library<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Immune mechanisms in drug addiction and critical illness, neurodegeneration, extracellular vesicle signaling Research Synopsis The overriding goal of Dr. Coleman\u2019s work is to identify novel treatments for alcohol use disorders (AUD) and associated peripheral disease pathologies.\u00a0 Currently, this includes: Neuroimmune Signaling in AUD The goal of this project is to determine the role &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/leon-coleman-md-phd\/\" aria-label=\"Read more about Leon Coleman, MD, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":11869,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-9308","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Leon Coleman, MD, PhD"],"_upd_reverse_display_name":["Coleman, Leon"],"_upd_last_name":["Coleman"],"_upd_first_name":["Leon"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Assistant Professor<\/strong>\r\n<span style=\"background-color: #007fae;color: #fff\">Accepting Rotation Students<\/span>\r\nResearch: Immune mechanisms in drug addiction and critical illness, neurodegeneration, extracellular vesicle signaling\r\nOffice: 1007C Thurston Bowles\r\nPhone: <a href=\"tel:9199660501\">(919) 966-0501<\/a>\r\n<a class=\"mail-link\" href=\"mailto:leon_coleman@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["MD"],"_upd_degree2":["PhD"],"_upd_email":[[{"email_text":"leon_coleman@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"(919) 966-0501","phone_type":"Office Phone","phone_override":""},{"phone_text":"(919) 966-5679","phone_type":"Fax","phone_override":""},{"phone_text":"(919) 966-0501 (Lab)"}]],"_upd_address":[[{"address":{"address-1":"104 Manning Dr.","address-2":"1007C Thurston Bowles Bldg","campus-box":"CB# 7178","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/9308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/9308\/revisions"}],"predecessor-version":[{"id":25281,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/directory\/9308\/revisions\/25281"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/11869"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=9308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}