{"id":24731,"date":"2025-02-27T16:08:50","date_gmt":"2025-02-27T21:08:50","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?p=24731"},"modified":"2025-05-30T12:16:48","modified_gmt":"2025-05-30T16:16:48","slug":"congratulations-to-our-new-phd-kaeli-welsh","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pharm\/congratulations-to-our-new-phd-kaeli-welsh\/","title":{"rendered":"Congratulations to our new PhD, Kaeli Welsh"},"content":{"rendered":"

Dr. Welsh successfully defended her PhD Thesis, \u201cRegulating the Anaphase-Promoting Complex\/Cyclosome (APC\/C): Intrinsic Mechanisms and Cell Cycle Inhibitors”<\/em> under the guidance of Dr. Nicholas Brown.<\/p>\n

\"Kaeli<\/p>\n

Publications<\/h2>\n

The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment.<\/a> Ledvin L, Gassaway BM, Tawil J, Urso O, Pizzo D,\u00a0Welsh KA<\/strong>, Bolhuis DL, Fisher D, Bonni A, Gygi SP, Brown NG, Ferguson CJ. Dev Cell. 2023 Dec 4;58(23):2666-2683.e9. doi: 10.1016\/j.devcel.2023.10.002. Epub 2023 Oct 23. PMID: 37875116. \u00a0PMC10872926<\/a><\/p>\n

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex\/cyclosome (APC\/C).<\/a> Bodrug T,\u00a0Welsh KA<\/strong>, Bolhuis DL, Paul\u0430konis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Nat Struct Mol Biol. 2023 Nov;30(11):1663-1674. doi: 10.1038\/s41594-023-01105-5. Epub 2023 Sep 21. PMID: 37735619 . PMC10643132<\/a><\/p>\n

Examining the mechanistic relationship of APC\/CCDH1<\/sup>\u00a0and its interphase inhibitor EMI1.<\/a> Bolhuis DL*, Martinez-Chacin RC*,\u00a0Welsh KA*<\/strong>, Bodrug T, Cui L, Emanuele MJ, Brown NG. Protein Sci. 2022 Jun;31(6):e4324. doi: 10.1002\/pro.4324. PMID: 35634770. PMC9112349<\/a><\/p>\n

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.<\/a> Welsh KA*<\/strong>, Bolhuis DL*, Nederstigt AE, Boyer J, Temple BRS, Bonacci T, Gu L, Ordureau A, Harper JW, Steimel JP, Zhang Q, Emanuele MJ, Harrison JS, Brown NG. EMBO J. 2022 Feb 1;41(3):e108823. doi: 10.15252\/embj.2021108823. Epub 2021 Dec 23. PMID: 34942047.\u00a0PMC8804933<\/a><\/p>\n

Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex\/Cyclosome and Its Role in Chromatin Regulation.<\/a> Bodrug T*,\u00a0Welsh KA*<\/strong>, Hinkle M, Emanuele MJ, Brown NG. Front Cell Dev Biol. 2021 May 24;9:687515. doi: 10.3389\/fcell.2021.687515. eCollection 2021. PMID: 34109183. PMC8182066<\/a><\/p>\n

*These authors contributed equally<\/p>\n

Dr. Welsh is also an author on a paper that has been accepted by Nature Communications which will be published shortly.<\/p>\n

Honors, Awards & Highlights<\/h2>\n

American Heart Association Award, January 2023<\/a>
\nKaeli Welsh, PhD student in Nicholas Brown\u2019s lab, received the Pre-doctoral Fellowship for her project, \u201cVisualizing Essential Molecular Mechanisms That Promote Mitotic Exit.\u201d<\/p>\n

Kaeli Welsh featured scholar in Carolina Grad Student F1rsts, April 2021<\/a>
\nCongratulations to graduate student, Kaeli Welsh (Brown Lab) for being a Carolina Grad Student F1rsts featured scholar!<\/p>\n

Pharmacology Thomas Collum Butler Award, December 2022<\/a>
\nThe Thomas Collum Butler Award recognizes the outstanding work of a PhD or MD\/PhD PHCO Graduate Student currently working in a core or joint PHCO lab. Selection is on the basis of merit.<\/p>\n

Congratulations, Kaeli, we wish you all the best!<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Welsh successfully defended her PhD Thesis, \u201cRegulating the Anaphase-Promoting Complex\/Cyclosome (APC\/C): Intrinsic Mechanisms and Cell Cycle Inhibitors” under the guidance of Dr. Nicholas Brown.<\/p>\n","protected":false},"author":22429,"featured_media":15921,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,19],"tags":[],"class_list":["post-24731","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-student-postdoc-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2021\/04\/KaeliWelsh-250sq.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2021\/04\/KaeliWelsh-250sq.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2021\/04\/KaeliWelsh-250sq.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2021\/04\/KaeliWelsh-250sq.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2021\/04\/KaeliWelsh-250sq-150x150.jpg","featured_image_alt":"Kaeli Welsh","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/"},{"name":"Student & Postdoc News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/student-postdoc-news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/24731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/comments?post=24731"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/24731\/revisions"}],"predecessor-version":[{"id":25198,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/24731\/revisions\/25198"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/15921"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=24731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/categories?post=24731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/tags?post=24731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}