{"id":24752,"date":"2025-02-27T15:57:34","date_gmt":"2025-02-27T20:57:34","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?p=24752"},"modified":"2025-03-11T16:32:52","modified_gmt":"2025-03-11T20:32:52","slug":"new-pagers-technology-builds-on-roth-labs-dreadds","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pharm\/new-pagers-technology-builds-on-roth-labs-dreadds\/","title":{"rendered":"New PAGERs technology builds on Roth lab&#8217;s DREADDs"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\"><p class=\"lead\">Dr. Bryan Roth and his lab previously developed synthetic GPCRs called DREADDs. This technology has in turn laid the foundation for a new technology, PAGERs, which has an innovative approach to controlling cell activity. <\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-23917\" src=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2024\/10\/Bryan-Roth-Westheimer-Award-lecture-300x200.jpeg\" alt=\"Bryan Roth, MD PhD, Michael J. Hooker Distinguished Professor Pharmacology delivers the Frank H. Westheimer Prize Lecture at Harvard.\" width=\"400\" height=\"267\" srcset=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2024\/10\/Bryan-Roth-Westheimer-Award-lecture-300x200.jpeg 300w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2024\/10\/Bryan-Roth-Westheimer-Award-lecture-1024x683.jpeg 1024w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2024\/10\/Bryan-Roth-Westheimer-Award-lecture-768x512.jpeg 768w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2024\/10\/Bryan-Roth-Westheimer-Award-lecture-600x400.jpeg 600w, https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2024\/10\/Bryan-Roth-Westheimer-Award-lecture.jpeg 1200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p><span class=\"s3\">\u00a0<strong>DREADDs <\/strong>(<span class=\"s1\">Designer Receptors Exclusively Activated by Designer Drugs)<\/span> are synthetic GPCRs that are activated in cells or transgenic animals only when researchers administer a specific drug. The new technology, called <\/span><span class=\"s1\"><b>PAGERs <\/b>(Programmable Antigen-gated G-protein-coupled Engineered Receptors) provide modular, customizable G-protein-coupled receptors for cell-signalling studies.\u00a0<\/span><\/p>\n<p><span class=\"s1\">The PAGERs <\/span><span class=\"s3\">modular system developed by Alice Ting of Sanford) and Yulong Li (Peking University), builds on Roth\u2019s existing DREADDs technology.\u00a0 <\/span><span class=\"s3\">Ting&#8217;s and Li&#8217;s paper \u201c<\/span><span class=\"s1\">Synthetic GPCRs for programmable sensing and control of cell behaviour,\u201d was published in Nature in December 2024.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The Nature article by Stephanie Melchor highlighting PAGERs includes an interview with Bryan Roth: <a href=\"https:\/\/www.nature.com\/articles\/d41586-024-04178-4\"><em>&#8220;Build your own receptor: modular system can be tailored to any antigen&#8221;<\/em><\/a>\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PAGERs, which has an innovative approach to controlling cell activity, was highlighted in Nature, including an interview with Bryan Roth<\/p>\n","protected":false},"author":22429,"featured_media":20166,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[18,2],"tags":[],"class_list":["post-24752","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty-news","category-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2023\/01\/bryan-roth-2022-250sq-2.png","featured_image_medium":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2023\/01\/bryan-roth-2022-250sq-2.png","featured_image_medium_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2023\/01\/bryan-roth-2022-250sq-2.png","featured_image_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2023\/01\/bryan-roth-2022-250sq-2.png","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2023\/01\/bryan-roth-2022-250sq-2-150x150.png","featured_image_alt":"Bryan Roth, MD, PhD","category_details":[{"name":"Faculty News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/faculty-news\/"},{"name":"News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/24752","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/comments?post=24752"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/24752\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/20166"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=24752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/categories?post=24752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/tags?post=24752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}