{"id":25689,"date":"2025-07-28T14:34:14","date_gmt":"2025-07-28T18:34:14","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?p=25689"},"modified":"2025-09-29T11:12:19","modified_gmt":"2025-09-29T15:12:19","slug":"congratulations-to-our-new-phd-bryan-guzman","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pharm\/congratulations-to-our-new-phd-bryan-guzman\/","title":{"rendered":"Congratulations to Our New PhD, Bryan Guzm\u00e1n!"},"content":{"rendered":"

Dr. Guzm\u00e1n successfully defended his PhD thesis, “Characterizing RNA G-quadruplex Recognition by Disordered Domains of RNA-Binding Proteins,” under the guidance of Dr. Daniel Dominguez.<\/p>\n

\"Bryan<\/p>\n

Publications<\/h2>\n

Guzm\u00e1n, B. B.*<\/strong>, Goda, G. A.*<\/strong>, Jimenez, A., Martyr, J. G., Hu, Y., Cavazos, F. F., Aleman, M. M., & Dominguez, D. (2025). Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR. bioRxiv<\/em>, 2025.05.01.651718. https:\/\/doi.org\/10.1101\/2025.05.01.651718<\/a><\/p>\n

Martyr, J. G.*<\/strong>, Guzm\u00e1n, B. B.*<\/strong>, Hu, Y., Rothacher, R. L., Mustoe, A. M., Aleman, M. M., & Dominguez, D. (2025). Massively parallel characterization of RNA G-quadruplex stability and molecular recognition. bioRxiv<\/em>, 2025.04.29.651304. https:\/\/doi.org\/10.1101\/2025.04.29.651304<\/a><\/p>\n

Gentile, G. M., Blue, R. E., Goda, G. A., Guzman, B. B.<\/strong>, Szymanski, R. A., Lee, E. Y., Engels, N. M., Hinkle, E. R., Wiedner, H. J., Bishop, A. N., Harrison, J. T., Zhang, H., Wehrens, X. H. T., Dominguez, D., & Giudice, J. (2025). Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases. RNA Biology<\/em>, 15476286.2025.2491160. https:\/\/doi.org\/10.1080\/15476286.2025.2491160<\/a><\/p>\n

Moffatt, C., Arora, A., Vaeth, K. F., Guzman, B. B.<\/strong>, Bhardwaj, G., Hoelscher, A., Gifford, L. B., Russ, H. A., Dominguez, D., & Taliaferro, J. M. (2025). TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability. bioRxiv<\/em>. https:\/\/doi.org\/10.1101\/2025.02.25.640092<\/a><\/p>\n

Harris, S. E., Hu, Y., Bridges, K., Cavazos, F. F., Martyr, J. G., Guzm\u00e1n, B. B.<\/strong>, Murn, J., Aleman, M. M., & Dominguez, D. (2025). Dissecting RNA selectivity mediated by tandem RNA-binding domains. The Journal of Biological Chemistry<\/em>, 108435. https:\/\/doi.org\/10.1016\/j.jbc.2025.108435<\/a><\/p>\n

Sahoo, B. R., Kocman, V., Clark, N., Myers, N., Deng, X., Wong, E. L., Yang, H. J., Kotar, A., Guzman, B. B.<\/strong>, Dominguez, D., Plavec, J., & Bardwell, J. C. A. (2024). Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation. Nucleic Acids Research<\/em>, 52<\/em>(8), 4702\u20134722. https:\/\/doi.org\/10.1093\/nar\/gkae229<\/a><\/p>\n

Zhuang, F., Gutman, D., Islas, N., Guzman, B. B.<\/strong>, Jimenez, A., Jewell, S., Hand, N. J., Nathanson, K., Dominguez, D., & Barash, Y. (2024). G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic data. bioRxiv<\/em>. https:\/\/doi.org\/10.1101\/2024.10.01.616124<\/a><\/p>\n

Sahoo, B. R., Deng, X., Wong, E. L., Clark, N., Yang, H., Subramanian, V., Guzman, B. B.<\/strong>, Harris, S. E., Dehury, B., Miyashita, E., Hoff, J. D., Kocaman, V., Saito, H., Dominguez, D., Plavec, J., & Bardwell, J. C. A. (2023). Visualizing liquid-liquid phase transitions. bioRxiv<\/em>. https:\/\/doi.org\/10.1101\/2023.10.09.561572<\/a><\/p>\n

Pimenta, F. M., Huh, J., Guzman, B.<\/strong>, Amanah, D., Marston, D. J., Pinkin, N. K., Danuser, G., & Hahn, K. M. (2023). Rho MultiBinder, a fluorescent biosensor that reports the activity of multiple GTPases. Biophysical Journal<\/em>, 122<\/em>(18), 3646\u20133655. https:\/\/doi.org\/10.1016\/j.bpj.2023.04.020<\/a><\/p>\n

Guzman, B. B.*<\/strong>, Son, A.*<\/strong>, Litberg, T. J.*<\/strong>, Huang, Z.*<\/strong>, Dominguez, D., & Horowitz, S. (2023). Emerging roles for G-quadruplexes in proteostasis. The FEBS Journal<\/em>, 290<\/em>(19), 4614\u20134625. https:\/\/doi.org\/10.1111\/febs.16608<\/a><\/p>\n

Hinkle, E. R., Wiedner, H. J., Torres, E. V., Jackson, M., Black, A. J., Blue, R. E., Harris, S. E., Guzman, B. B.<\/strong>, Gentile, G. M., Lee, E. Y., Tsai, Y.-H., Parker, J., Dominguez, D., & Giudice, J. (2022). Alternative splicing regulation of membrane trafficking genes during myogenesis. RNA<\/em>, 28<\/em>(4), 523\u2013540. https:\/\/doi.org\/10.1261\/rna.078993.121<\/a><\/p>\n

Guzman, B. B.<\/strong>, Schauer, A. P., Dunn, J. A., Cottrell, M. L., & Sykes, C. (2021). A quantitative LC\u2013MS\/MS method for the determination of tissue brincidofovir and cidofovir diphosphate in a MuPyV\u2010infected mouse model. Biomedical Chromatography<\/em>, 35<\/em>(5), e5061. https:\/\/doi.org\/10.1002\/bmc.5061<\/a><\/p>\n

Goering, R., Hudish, L. I., Guzman, B. B.<\/strong>, Raj, N., Bassell, G. J., Russ, H. A., Dominguez, D., & Taliaferro, J. M. (2020). FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences. eLife<\/em>, 9<\/em>, e52621. https:\/\/doi.org\/10.7554\/eLife.52621<\/a><\/p>\n

Sykes, C., Blake, K., White, N., Schauer, A. P., Guzman, B. B.<\/strong>, Cottrell, M. L., Tamraz, B., & Kashuba, A. D. M. (2018). Development and validation of an LC-MS\/MS assay for the quantification of dolutegravir extracted from human hair. Analytical and Bioanalytical Chemistry<\/em>, 410<\/em>(29), 7773\u20137781. https:\/\/doi.org\/10.1007\/s00216-018-1394-y<\/a><\/p>\n

\"Bryan<\/a>
Bryan presents his thesis defense<\/div><\/div>
\"Dr.<\/a>
Henrik congratulates Bryan after his defense<\/div><\/div><\/div><\/div>\n

Congratulations, Bryan, we wish you all the best!<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Guzman successfully defended his PhD thesis, “Characterizing RNA G-quadruplex Recognition by Disordered Domains of RNA-Binding Proteins,” under the guidance of Dr. Daniel Dominguez.<\/p>\n","protected":false},"author":22429,"featured_media":25699,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,19],"tags":[],"class_list":["post-25689","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-student-postdoc-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2025\/07\/Bryan-guzman-phd-defense-250.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2025\/07\/Bryan-guzman-phd-defense-250.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2025\/07\/Bryan-guzman-phd-defense-250.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2025\/07\/Bryan-guzman-phd-defense-250.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2025\/07\/Bryan-guzman-phd-defense-250-150x150.jpg","featured_image_alt":"","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/"},{"name":"Student & Postdoc News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/student-postdoc-news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/25689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/comments?post=25689"}],"version-history":[{"count":7,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/25689\/revisions"}],"predecessor-version":[{"id":26786,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/25689\/revisions\/26786"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/25699"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=25689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/categories?post=25689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/tags?post=25689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}