{"id":27852,"date":"2026-04-30T12:47:53","date_gmt":"2026-04-30T16:47:53","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?p=27852"},"modified":"2026-04-30T12:47:53","modified_gmt":"2026-04-30T16:47:53","slug":"congratulations-to-our-new-phd-cole-martin","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pharm\/congratulations-to-our-new-phd-cole-martin\/","title":{"rendered":"Congratulations to our new PhD, Cole Martin!"},"content":{"rendered":"

<\/p>Dr. Martin successfully defended his PhD thesis,\u00a0“Changing The Guardian’s Playbook: Dissecting How Cancer Driver Rewire p53 Gene Regulatory Networks,” under the guidance of Dr. John Morris IV!<\/span>[\\lead]\n

\"Cole
Cole P. Martin, PhD, being congratulated at his defense.<\/figcaption><\/figure>\n

Publications<\/h2>\n

p53 and YAP\/TAZ-TEAD activities determine metaplastic heterogeneity in pancreatic cancer.\u00a0<\/a>Cole P.\u00a0Martin,\u00a0Scott\u00a0Bang,\u00a0Joseph R.\u00a0Gomes,\u00a0William B.\u00a0Sullivan,\u00a0Yusha\u00a0Liu,\u00a0Matthew D.\u00a0Smith,\u00a0A. Cole\u00a0Edwards,\u00a0Channing J.\u00a0Der,\u00a0John P.\u00a0Morris\u00a0IV.\u00a0bioRxiv\u00a02025.12.11.693520;\u00a0doi: https:\/\/doi.org\/10.64898\/2025.12.11.693520.<\/p>\n

p53 activity licenses transcriptional regulation by YAP\/TAZ-TEAD to shape expression landscapes during tumorigenesis.\u00a0<\/a>Cole\u00a0Martin,\u00a0William B.\u00a0Sullivan,\u00a0Scott\u00a0Bang,\u00a0Joseph R.\u00a0Gomes,\u00a0A. Cole\u00a0Edwards,\u00a0Channing J.\u00a0Der,\u00a0Cheng\u00a0Fan,\u00a0Yusha\u00a0Liu,\u00a0John P.\u00a0Morris\u00a0IV.\u00a0bioRxiv\u00a02025.09.29.679387;\u00a0doi: https:\/\/doi.org\/10.1101\/2025.09.29.679387.<\/p>\n

Mutant IDH uncouples p53 from target gene regulation to disable tumor suppression.<\/a>\u00a0Cole\u00a0Martin,\u00a0William B.\u00a0Sullivan,\u00a0Jacqueline\u00a0Brinkman,\u00a0Deena\u00a0Scoville,\u00a0Jossie J\u00a0Yashinskie,\u00a0Sha\u00a0Tian,\u00a0Riccardo E.\u00a0Mezzadra,\u00a0Yu-Jui\u00a0Ho,\u00a0Richard P.\u00a0Koche,\u00a0Timour\u00a0Baslan,\u00a0Jesse\u00a0Raab,\u00a0David\u00a0Corcoran,\u00a0Lydia W.S.\u00a0Finley,\u00a0Scott W.\u00a0Lowe,\u00a0John P.\u00a0Morris\u00a0IV.\u00a0bioRxiv\u00a02024.09.30.615916;\u00a0doi: https:\/\/doi.org\/10.1101\/2024.09.30.615916.<\/p>\n

Honors, Awards & Highlights<\/h2>\n

Best Oral Presentation at the Pharmacology, 2025 Retreat<\/p>\n

Thomas Collum Butler Award from the Department of Pharmacology in 2024 for outstanding research by a pharmacology trainee.<\/p>\n

UNC Pharmacology Laboratory Mentorship Shoutout 2024<\/p>\n

Mechanistic and Interdisciplinary Program T32 Training Grant<\/p>\n

We wish you all the best, Cole!<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Martin successfully defended his PhD thesis,\u00a0“Changing The Guardian’s Playbook: Dissecting How Cancer Driver Rewire p53 Gene Regulatory Networks,” under the guidance of Dr. John Morris IV!<\/p>\n","protected":false},"author":22429,"featured_media":27860,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,2,19],"tags":[],"class_list":["post-27852","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","category-news","category-student-postdoc-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/04\/ColeMartin-defense-250CR.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/04\/ColeMartin-defense-250CR.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/04\/ColeMartin-defense-250CR.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/04\/ColeMartin-defense-250CR.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/04\/ColeMartin-defense-250CR-150x150.jpg","featured_image_alt":"Cole P. Martin, PhD at his defense","category_details":[{"name":"Featured News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/featured\/"},{"name":"News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/"},{"name":"Student & Postdoc News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/student-postdoc-news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/27852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/comments?post=27852"}],"version-history":[{"count":7,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/27852\/revisions"}],"predecessor-version":[{"id":27863,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/27852\/revisions\/27863"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/27860"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=27852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/categories?post=27852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/tags?post=27852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}