{"id":27948,"date":"2026-05-13T14:28:40","date_gmt":"2026-05-13T18:28:40","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?p=27948"},"modified":"2026-05-13T14:29:33","modified_gmt":"2026-05-13T18:29:33","slug":"congratulations-to-our-new-phd-sabrina-daglish","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pharm\/congratulations-to-our-new-phd-sabrina-daglish\/","title":{"rendered":"Congratulations to our new PhD, Sabrina Daglish!"},"content":{"rendered":"

Dr. Daglish successfully defended her PhD thesis, \u201cSmall Molecule ClpP Activators Impair Mitochondrial Function and Induce Senescence in Triple-Negative Breast Cancer\u201d under the direction of Dr. Lee Graves!<\/p>\n

\"Sabrina<\/a><\/p>\n

Dr. Daglish will be moving to the Bay area to start a postdoctoral fellowship position with Gilead Sciences.<\/p>\n

Publications<\/h2>\n

Small Molecule Activators of the Mitochondrial Protease ClpP Induce Senescence in Triple-Negative Breast Cancer Cells and Sensitize Cells to the Bcl-2 Inhibitor Venetoclax.<\/a> Daglish SCD<\/strong>,\u00a0Canterbury OG, Graves PR, Carter SA, Beese SM, Hynek MA, Mouery BL, Mistreanu AJ, Bhatt AP, Tellez N, Butler MT, Aponte-Collazo LJ, Fennell EMJ, Herring LE, Lyons S, Mills CA, Ashamalla H, Iwanowicz EJ, Morris JP 4th, Bear JE, Greer YE, Lipkowitz S, Graves LM. \u00a0Res Sq [Preprint]. 2025 Nov 19:rs.3.rs-7682325. doi: 10.21203\/rs.3.rs-7682325\/v1.\u00a0\u00a0PMID:\u00a041333384. PMC13089524<\/p>\n

Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants.<\/a> Capener JL, Vasta JD, Katis VL, Michaud A, Beck MT, Daglish SCD<\/strong>, Cohen-Kedar S, Barda ES, Howell S, Dotan I, Robers MB, Axtman AD, Bashore FM. Front Chem Biol. 2024;3:10.3389\/fchbi.2024.1447622. doi: 10.3389\/fchbi.2024.1447622. Epub 2024 Jul 28. PMID:\u00a042004161 PMC13089524<\/p>\n

Combining the constitutive TRAIL-secreting induced neural stem cell therapy with the novel anti-cancer drug TR-107 in glioblastoma.\u00a0<\/a>Thang M, Mellows C, Kass LE, Daglish S,<\/strong> Fennell EMJ, Mann BE, Mercer-Smith AR, Valdivia A, Graves LM, Hingtgen SD. Mol Ther Oncol. 2024 Jun 15;32(3):200834. doi: 10.1016\/j.omton.2024.200834. eCollection 2024 Sep 19. PMID:\u00a039045029. PMC11263637.<\/p>\n

Targeting Mitochondrial DNA Transcription by POLRMT Inhibition or Depletion as a Potential Strategy for Cancer Treatment. <\/a>Daglish SCD<\/strong>, Fennell EMJ, Graves LM. Biomedicines. 2023 May 31;11(6):1598. doi: 10.3390\/biomedicines11061598. PMID:\u00a037371693 PMC10295849<\/p>\n

Honors, Awards & Highlights<\/h2>\n

Best Poster Presentation Award, Pharmacology Research Retreat 2025<\/span><\/p>\n

We wish you all the best, Sabrina!<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Daglish successfully defended her PhD thesis, “Small Molecule ClpP Activators Impair Mitochondrial Function and Induce Senescence in Triple-Negative Breast Cancer,” under the direction of Dr. Lee Graves!<\/p>\n","protected":false},"author":22429,"featured_media":27960,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,2,19],"tags":[],"class_list":["post-27948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","category-news","category-student-postdoc-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/05\/Sabrina-Daglish-phd-defense-250-3.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/05\/Sabrina-Daglish-phd-defense-250-3.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/05\/Sabrina-Daglish-phd-defense-250-3.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/05\/Sabrina-Daglish-phd-defense-250-3.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2026\/05\/Sabrina-Daglish-phd-defense-250-3-150x150.jpg","featured_image_alt":"Sabrina Daglish, PhD, at her defense","category_details":[{"name":"Featured News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/featured\/"},{"name":"News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/"},{"name":"Student & Postdoc News","link":"https:\/\/www.med.unc.edu\/pharm\/category\/news\/student-postdoc-news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/27948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/comments?post=27948"}],"version-history":[{"count":9,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/27948\/revisions"}],"predecessor-version":[{"id":27958,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/posts\/27948\/revisions\/27958"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media\/27960"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/media?parent=27948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/categories?post=27948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pharm\/wp-json\/wp\/v2\/tags?post=27948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}