{"id":4635,"date":"2021-09-27T19:54:51","date_gmt":"2021-09-27T23:54:51","guid":{"rendered":"https:\/\/www.med.unc.edu\/ppmh\/?p=4635"},"modified":"2021-09-27T19:54:51","modified_gmt":"2021-09-27T23:54:51","slug":"precision-medicine-social-determinants-of-health-mini-symposium-and-forum-october-27-2021","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/ppmh\/2021\/09\/precision-medicine-social-determinants-of-health-mini-symposium-and-forum-october-27-2021\/","title":{"rendered":"Pharmacogenomics and Decision Support in the EHR | Mini-symposium and Forum | October 27, 2021"},"content":{"rendered":"

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Join the UNC Program for Precision Medicine in Healthcare (PPMH) for Precision Health @UNC: Pharmacogenomics and Decision Support in the EHR<\/strong>, a virtual mini-symposium on Wednesday October 27th from 1:00 to 3:00pm<\/strong>. At this interactive event, you will engage in discussion with leading Precision Medicine researchers at UNC. Presenters will explore mechanisms for predicting how a patient’s genome will influence their response to medications, implementing pharmacogenomics in the clinic, and development of EHR decision support.
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Presenters:<\/span><\/p>\n

\"\"Daniel Crona, PharmD, PhD:<\/a> The ongoing quest for perfection \u2013 or at least precision \u2013 of tacrolimus dosing in bone marrow transplant
\n<\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Associate Professor, Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy<\/span><\/span><\/span><\/p>\n

This presentation focuses on attempts at UNC to develop a precision dosing model of tacrolimus for patients receiving an allogeneic stem cell transplant. Specifically, we will discuss tacrolimus pharmacogenetics and the development of a tacrolimus population pharmacokinetic model, which serve as the foundation for our precision dosing efforts. Ultimately, we believe that a tacrolimus precision dosing model will replace a \u201cone size fits all\u201d dosing paradigm, and will better help to prevent severe acute graft-versus-host syndrome and tacrolimus toxicities.<\/p>\n

 <\/p>\n

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\"\" Klarissa Jackson, PhD:<\/a> Interindividual variability in drug metabolism: Implications for precision medicine in ethnically diverse populations<\/span>
\n<\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Assistant Professor, Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy<\/span><\/span><\/span><\/p>\n

This presentation will focus on recent findings regarding the influence of interindividual variation in cytochrome P450 (CYP) 3A enzyme activity on the metabolism of anti-cancer small molecule tyrosine kinase inhibitors, using lapatinib as a case study. Lapatinib undergoes metabolic activation by CYP3A4 and polymorphic CYP3A5 to form a chemically reactive metabolite, which is implicated in drug-induced liver injury. In this presentation, we will discuss the application of integrated in vitro<\/em> approaches to examine interindividual differences in the metabolic activation of lapatinib. We will also discuss the implications of our findings for future translational studies to investigate how genetic and non-genetic factors affect drug metabolism and drug response in patients from understudied ethnic backgrounds.<\/p>\n

\u00a0<\/span><\/p>\n

\"\" \u00a0 Erin Heinzen, PharmD, PhD:<\/a> The impact of recent gene discovery on treatment selection in epilepsy
\n<\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Associate Professor, Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy<\/span><\/span><\/p>\n

This presentation will discuss recent progress in epilepsy genetics and how these discoveries are being used to guide treatment approaches in patients with different types of genetic epilepsy.<\/span><\/p>\n

 <\/p>\n

This dynamic discussion forum will explore the breadth of Precision Health initiatives at UNC and facilitate connections between colleagues with similar research interests. We hope to see you there!<\/span><\/p>\n

Event Agenda:<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
1:00-1:05<\/td>\nIntroductions<\/td>\n<\/tr>\n
1:05-1:30<\/td>\nDaniel Crona presentation<\/td>\n<\/tr>\n
1:30-1:55<\/td>\nKlarissa Jackson presentation<\/td>\n<\/tr>\n
1:55-2:20<\/td>\nErin Heinzen\u00a0presentation<\/td>\n<\/tr>\n
2:20-2:55<\/td>\nPanel discussion<\/td>\n<\/tr>\n
2:55-3:00<\/td>\nClosing remarks<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Click here<\/a> to register.<\/span><\/p>\n

Email precisionmedicine@med.unc.edu<\/a> for more information.<\/span><\/p>\n

Click here to download the event flyer: PPMH mini-symposium poster Oct2021<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Join the UNC Program for Precision Medicine in Healthcare (PPMH) for Precision Health @UNC: Pharmacogenomics and Decision Support in the EHR, a virtual mini-symposium on Wednesday October 27th from 1:00 to 3:00pm. At this interactive event, you will engage in discussion with leading Precision Medicine researchers at UNC. Presenters will explore mechanisms for predicting how … Read more<\/a><\/p>\n","protected":false},"author":81071,"featured_media":4636,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[8],"tags":[],"class_list":["post-4635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-past","odd"],"acf":[],"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":"","category_details":[{"name":"past","link":"https:\/\/www.med.unc.edu\/ppmh\/category\/past\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/posts\/4635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/users\/81071"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/comments?post=4635"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/posts\/4635\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/media?parent=4635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/categories?post=4635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/ppmh\/wp-json\/wp\/v2\/tags?post=4635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}