{"id":45,"date":"2023-05-16T01:58:12","date_gmt":"2023-05-16T01:58:12","guid":{"rendered":"https:\/\/www.med.unc.edu\/pru\/?page_id=45"},"modified":"2023-06-22T00:47:54","modified_gmt":"2023-06-22T00:47:54","slug":"nsg-nu-nu-mouse-colonies","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pru\/services\/nsg-nu-nu-mouse-colonies\/","title":{"rendered":"NSG & Nu\/Nu Mouse Colonies"},"content":{"rendered":"

The Preclinical Research Unit (PRU) maintains colonies of immune-compromised mice to facilitate your pre-clinical oncology and immune function research. All mice are housed in a barrier facility which maintains the highest level of health status available to UNC researchers.<\/p>\n

Strains<\/h2>\n

NSG<\/strong>; NOD.Cg-Prkdcscid<\/sup> Il2rgtm1Wjl<\/sup> \/SzJ; NOD-scid IL2Rgammanull<\/sup><\/p>\n

NSG mice carry two mutations on the NOD\/ShiLtJ background and a complete null allele of the IL2 receptor common gamma chain which renders them B, T and functional NK cell deficient. These mice are commonly used for humanization through engraftment of HSCs, PBMCs, PDXs or adult stem cells and tissues.<\/p>\n

Nu\/Nu<\/strong>; NU-Foxn1nu<\/sup><\/p>\n

Nu\/nu mice are maintained as outbred and are not associated with any background stock or strain. They lack a thymus and are unable to produce T-cells. Nu\/nu mice are ideal for tumor biology and xenograft research.<\/p>\n

 <\/p>\n

Please contact pruadmin@office@unc.edu<\/span><\/span><\/a>\u00a0<\/span><\/span>\u00a0for more information.<\/p>\n","protected":false},"excerpt":{"rendered":"

The Preclinical Research Unit (PRU) maintains colonies of immune-compromised mice to facilitate your pre-clinical oncology and immune function research. All mice are housed in a barrier facility which maintains the highest level of health status available to UNC researchers. 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