{"id":67,"date":"2023-05-16T02:22:06","date_gmt":"2023-05-16T02:22:06","guid":{"rendered":"https:\/\/www.med.unc.edu\/pru\/?page_id=67"},"modified":"2024-07-02T13:22:21","modified_gmt":"2024-07-02T13:22:21","slug":"science","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pru\/science\/","title":{"rendered":"Science"},"content":{"rendered":"<h2>GEMM<\/h2>\n<p>Genetically Engineered Mouse Models (GEMM) are transgenic animals in which gene knock-out and knock-in technologies have made it possible for us to more faithfully mimic the genetic and biological evolution of human cancers. GEMM studies by nature take longer to fill cohorts due to genetic mutations required for experimental animals due to more breeding required. The PRU has 3 actively breeding models for breast cancer research.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h3><strong>Breast<\/strong><\/h3>\n<p><strong>\u00a0<\/strong><\/p>\n<ul>\n<li><strong>C3(1)Tag<\/strong><\/li>\n<\/ul>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9458374\/\">Genetic alterations in the development of mammary and prostate cancer in the C3(1)\/Tag transgenic mouse model.<\/a><br \/>\nYoshidome K, Shibata M, Maroulakou I, Liu M, Jorcyk C, Gold L, Welch V and Green J: . Int J Oncol 12: 449-502, 1998;\u00a0<span class=\"identifier pubmed\"><span class=\"id-label\">PMID:\u00a0<\/span>9458374<\/span><\/p>\n<ul>\n<li><strong>MMTV-PyVT<br \/>\n<\/strong><\/li>\n<\/ul>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1312220\/\">Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.<\/a><br \/>\nGuy CT; Cardiff RD; Muller WJ: Mol Cell Biol 12(3):954-61 MGI: J:46460 PMID: 1312220<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>MMTV-Neu\u00a0<\/strong><\/li>\n<\/ul>\n<p><u><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27265747\">Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.<\/a><\/u><br \/>\nAlwarawrah Y, Hughes P, Loiselle D, Carlson DA, Darr DB, Jordan JL, Xiong J, Hunter LM, Dubois LG, Thompson JW, Kulkarni MM, Ratcliff AN, Kwiek JJ, Haystead TA.<br \/>\nCell Chem Biol. 2016 Jun 23;23(6):678-88. doi: 10.1016\/j.chembiol.2016.04.011. Epub 2016 Jun 2. PMID:\u00a0 27265747<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><u><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29254140\">Differential response to exercise in claudin-low breast cancer.<\/a><\/u><br \/>\nGlass OK, Bowie M, Fuller J, Darr D, Usary J, Boss K, Choudhury KR, Liu X, Zhang Z, Locasale JW, Williams C, Dewhirst MW, Jones LW, Seewaldt V.<br \/>\nOncotarget. 2017 Sep 19;8(60):100989-101004. doi: 10.18632\/oncotarget.21054. eCollection 2017 Nov 24. PMID:\u00a0 29254140<\/p>\n","protected":false},"excerpt":{"rendered":"<p>GEMM Genetically Engineered Mouse Models (GEMM) are transgenic animals in which gene knock-out and knock-in technologies have made it possible for us to more faithfully mimic the genetic and biological evolution of human cancers. GEMM studies by nature take longer to fill cohorts due to genetic mutations required for experimental animals due to more breeding &hellip; <a href=\"https:\/\/www.med.unc.edu\/pru\/science\/\" aria-label=\"Read more about Science\">Read more<\/a><\/p>\n","protected":false},"author":55643,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":""},"class_list":["post-67","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Science - Preclinical Research Unit<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pru\/science\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science - Preclinical Research Unit\" \/>\n<meta property=\"og:description\" content=\"GEMM Genetically Engineered Mouse Models (GEMM) are transgenic animals in which gene knock-out and knock-in technologies have made it possible for us to more faithfully mimic the genetic and biological evolution of human cancers. GEMM studies by nature take longer to fill cohorts due to genetic mutations required for experimental animals due to more breeding &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pru\/science\/\" \/>\n<meta property=\"og:site_name\" content=\"Preclinical Research Unit\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-02T13:22:21+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pru\/science\/\",\"url\":\"https:\/\/www.med.unc.edu\/pru\/science\/\",\"name\":\"Science - Preclinical Research Unit\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pru\/#website\"},\"datePublished\":\"2023-05-16T02:22:06+00:00\",\"dateModified\":\"2024-07-02T13:22:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pru\/science\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pru\/science\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pru\/science\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pru\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Science\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pru\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pru\/\",\"name\":\"Preclinical Research Unit\",\"description\":\"UNC Lineberger Comprehensive Cancer Center\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pru\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Science - Preclinical Research Unit","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pru\/science\/","og_locale":"en_US","og_type":"article","og_title":"Science - Preclinical Research Unit","og_description":"GEMM Genetically Engineered Mouse Models (GEMM) are transgenic animals in which gene knock-out and knock-in technologies have made it possible for us to more faithfully mimic the genetic and biological evolution of human cancers. GEMM studies by nature take longer to fill cohorts due to genetic mutations required for experimental animals due to more breeding &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/pru\/science\/","og_site_name":"Preclinical Research Unit","article_modified_time":"2024-07-02T13:22:21+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/pru\/science\/","url":"https:\/\/www.med.unc.edu\/pru\/science\/","name":"Science - Preclinical Research Unit","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/pru\/#website"},"datePublished":"2023-05-16T02:22:06+00:00","dateModified":"2024-07-02T13:22:21+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/pru\/science\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/pru\/science\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/pru\/science\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/pru\/"},{"@type":"ListItem","position":2,"name":"Science"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/pru\/#website","url":"https:\/\/www.med.unc.edu\/pru\/","name":"Preclinical Research Unit","description":"UNC Lineberger Comprehensive Cancer Center","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/pru\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/pages\/67","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/users\/55643"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/pages\/67\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/media?parent=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}