{"id":71,"date":"2023-05-16T02:23:54","date_gmt":"2023-05-16T02:23:54","guid":{"rendered":"https:\/\/www.med.unc.edu\/pru\/?page_id=71"},"modified":"2023-06-22T01:27:07","modified_gmt":"2023-06-22T01:27:07","slug":"syngeneic","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/","title":{"rendered":"Syngeneic"},"content":{"rendered":"<p>While GEMMS off whole animal microenvironment for tumor studies, the PRU has the capability to ramp up project speeds by using syngeneic tumor grafts or cell line implants. Large cohorts of animals can be studied simultaneously to meet the requirements of the project. The current models we have readily available are:<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<ul>\n<li><strong>T11 (Breast) \u2013<\/strong>\u00a0The T11 model is a transplantable orthotopic model derived from a mammary epithelial tumor containing\u00a0<em>Trp53<\/em>\u00a0 (<em>Jerry et al., Oncogene 2000<\/em>\u00a0\u2013 PMID:\u00a0 10713689).\u00a0 This model was genomically characterized by Dr. Charles Perou and represents the claudin-low subtype of human breast tumors tumors (<em>Pfefferle et al. Genome Biology 2013<\/em>\u00a0\u2013 PMID:\u00a0 24220145). As subset of the Triple-negative phenotype (ER-, PR-, HER2-), these tumors are seen in 15% of all human breast cases. They are highly refractory to chemotherapy and offer a much worse prognosis for the patient.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Braf PTEN Tyr-Cre (Melanoma)<\/strong><\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<ul>\n<li><strong>K14pBRCA1_B (Breast)<\/strong><\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<ul>\n<li><strong>BBN (Bladder)<\/strong><\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<ul>\n<li><strong>UPPL (Bladder)<\/strong><\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<ul>\n<li><strong>TRIA (Melanoma)<\/strong><\/li>\n<\/ul>\n<p>If you wish to discuss how to incorporate your models in efficacy studies, please contact Dr. Aadra Bhatt at <a href=\"mailto:aadra_bhatt@med.unc.edu\">aadra_bhatt@med.unc.edu<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>While GEMMS off whole animal microenvironment for tumor studies, the PRU has the capability to ramp up project speeds by using syngeneic tumor grafts or cell line implants. Large cohorts of animals can be studied simultaneously to meet the requirements of the project. The current models we have readily available are: \u00a0 T11 (Breast) \u2013\u00a0The &hellip; <a href=\"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/\" aria-label=\"Read more about Syngeneic\">Read more<\/a><\/p>\n","protected":false},"author":55643,"featured_media":0,"parent":67,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":""},"class_list":["post-71","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Syngeneic - Preclinical Research Unit<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Syngeneic - Preclinical Research Unit\" \/>\n<meta property=\"og:description\" content=\"While GEMMS off whole animal microenvironment for tumor studies, the PRU has the capability to ramp up project speeds by using syngeneic tumor grafts or cell line implants. Large cohorts of animals can be studied simultaneously to meet the requirements of the project. 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Large cohorts of animals can be studied simultaneously to meet the requirements of the project. The current models we have readily available are: \u00a0 T11 (Breast) \u2013\u00a0The &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/","og_site_name":"Preclinical Research Unit","article_modified_time":"2023-06-22T01:27:07+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/","url":"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/","name":"Syngeneic - Preclinical Research Unit","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/pru\/#website"},"datePublished":"2023-05-16T02:23:54+00:00","dateModified":"2023-06-22T01:27:07+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/pru\/science\/syngeneic\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/pru\/"},{"@type":"ListItem","position":2,"name":"Science","item":"https:\/\/www.med.unc.edu\/pru\/science\/"},{"@type":"ListItem","position":3,"name":"Syngeneic"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/pru\/#website","url":"https:\/\/www.med.unc.edu\/pru\/","name":"Preclinical Research Unit","description":"UNC Lineberger Comprehensive Cancer Center","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/pru\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/pages\/71","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/users\/55643"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/comments?post=71"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/pages\/71\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/pages\/67"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pru\/wp-json\/wp\/v2\/media?parent=71"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}