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Informed consent: Old and new challenges in the context of the COVID-19 pandemic

September 13, 2021

Through the lens of the experiences of and challenges for Clinical and Translation Science Award (CTSA) institutions, this paper addresses how COVID-19 has impacted informed consent for clinical research, including an overview of informed consent and the challenges that existed prior to COVID-19, modifications to informed consent processes in response to the pandemic, lessons learned, … Read more

Discriminatory experiences predict neuroanatomical changes and anxiety among healthy individuals and those at clinical high risk for psychosis

September 13, 2021

Individuals face discrimination and discriminatory experiences (DE) based on characteristics including race/ethnicity, gender, age, and disability. This report assessed whether lifetime DE are associated with changes in brain structure (e.g. cortical thinning) and clinical outcomes across time. This report provides the first evidence to date of an association between DE and brain structure in both … Read more

A Clinical Brexanolone Treatment Program at an Academic Medical Center- challenges and lessons learned with patient selection and post 30 day outcomes

September 13, 2021

Brexanolone (Zulresso) is the first Federal Drug Administration (FDA) approved drug for the treatment of postpartum depression (PPD). Brexanolone is a positive allosteric modulator of the GABAA receptor, and is given over 60 hours by infusion in a medical setting. This drug has been shown to be effective at significantly reducing Hamilton Rating Scale for Depression … Read more