{"id":13972,"date":"2022-03-22T10:51:06","date_gmt":"2022-03-22T14:51:06","guid":{"rendered":"https:\/\/www.med.unc.edu\/psych\/cecmh\/?page_id=13972"},"modified":"2022-11-08T13:53:19","modified_gmt":"2022-11-08T18:53:19","slug":"clozapine-toolkit","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/","title":{"rendered":"Clozapine Toolkit"},"content":{"rendered":"<h4><a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/UNC-Outpatient-Clozapine-Titration-Schedule-2-2022-1.pdf\" target=\"_blank\" rel=\"noopener\"><strong>NCCN Outpatient Clozapine Initiation Titration Schedule<\/strong><\/a><\/h4>\n<p><span id=\"page3R_mcid0\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">A<\/span> <span dir=\"ltr\" role=\"presentation\">sa<\/span><span dir=\"ltr\" role=\"presentation\">mple<\/span> <span dir=\"ltr\" role=\"presentation\">titration schedule<\/span><span dir=\"ltr\" role=\"presentation\">. Adjustments may be needed based on <\/span><span dir=\"ltr\" role=\"presentation\">individual<\/span> <span dir=\"ltr\" role=\"presentation\">tolerability;<\/span> <span dir=\"ltr\" role=\"presentation\">we<\/span> <span dir=\"ltr\" role=\"presentation\">recommend a slower titratio<\/span><span dir=\"ltr\" role=\"presentation\">n<\/span> <span dir=\"ltr\" role=\"presentation\">whe<\/span><span dir=\"ltr\" role=\"presentation\">n<\/span> <span dir=\"ltr\" role=\"presentation\">the<\/span><span dir=\"ltr\" role=\"presentation\">re are<\/span> <span dir=\"ltr\" role=\"presentation\">greater than <\/span><span dir=\"ltr\" role=\"presentation\">mild side effects.<\/span> <span dir=\"ltr\" role=\"presentation\">We<\/span> <span dir=\"ltr\" role=\"presentation\">also recommend consolidating<\/span> <span dir=\"ltr\" role=\"presentation\">to nighttime<\/span> <span dir=\"ltr\" role=\"presentation\">dosi<\/span><span dir=\"ltr\" role=\"presentation\">ng<\/span> <span dir=\"ltr\" role=\"presentation\">in<\/span> <span dir=\"ltr\" role=\"presentation\">cases of <\/span><span dir=\"ltr\" role=\"presentation\">excessive<\/span> <span dir=\"ltr\" role=\"presentation\">daytime sedation<\/span> <span dir=\"ltr\" role=\"presentation\">OR difficult<\/span><span dir=\"ltr\" role=\"presentation\">y with<\/span> <span dir=\"ltr\" role=\"presentation\">optimal medication adherence.<\/span> <span dir=\"ltr\" role=\"presentation\">Target<\/span> <span dir=\"ltr\" role=\"presentation\">dose of 300 mg is the typical minimum dose need<\/span><span dir=\"ltr\" role=\"presentation\">ed to achieve therapeu<\/span><span dir=\"ltr\" role=\"presentation\">tic effect, <\/span><span dir=\"ltr\" role=\"presentation\">although this va<\/span><span dir=\"ltr\" role=\"presentation\">ries widely<\/span> <span dir=\"ltr\" role=\"presentation\">due to individual variability.<\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-13977\" src=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-300x120.jpg\" alt=\"Sample Clozapine Titration Schedule\" width=\"300\" height=\"120\" srcset=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-300x120.jpg 300w, https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-768x308.jpg 768w, https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-600x240.jpg 600w, https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule.jpg 839w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<h4><strong><a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/consultation-service\/\">NCCN Rapid Clozapine Initiation for Suicidality, Violence, or other Substantial Risk<\/a><\/strong><\/h4>\n<p>Please contact the NCCN <a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/consultation-service\/\">Consultation Service<\/a> for Assistance.<\/p>\n<h4><\/h4>\n<h4><a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Clozapine_intiation_schedule_outpt_7-31-19.pdf\" target=\"_blank\" rel=\"noopener\"><strong>NCCN Clozapine Initiation and Maintenance Monitoring Guidelines<\/strong><\/a><\/h4>\n<p>Clozapine initiation and monitoring grid: <span dir=\"ltr\" role=\"presentation\">CBC, <\/span><span dir=\"ltr\" role=\"presentation\">Myocarditis, ECG, Glucose, Vitals, ROS<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">IMPORTANT<\/span><span dir=\"ltr\" role=\"presentation\">:<\/span> <span dir=\"ltr\" role=\"presentation\">If conce<\/span><span dir=\"ltr\" role=\"presentation\">rned about p<\/span><span dir=\"ltr\" role=\"presentation\">ossible myocarditis and<\/span> <span dir=\"ltr\" role=\"presentation\">patient is not in distress, o<\/span><span dir=\"ltr\" role=\"presentation\">btain ECG and consult cardiology<\/span><span dir=\"ltr\" role=\"presentation\">. With <\/span><span dir=\"ltr\" role=\"presentation\">any symptomatic<\/span> <span dir=\"ltr\" role=\"presentation\">distress, have<\/span> <span dir=\"ltr\" role=\"presentation\">low threshold for b<\/span><span dir=\"ltr\" role=\"presentation\">ring<\/span><span dir=\"ltr\" role=\"presentation\">in<\/span><span dir=\"ltr\" role=\"presentation\">g patient to ED or instruct<\/span><span dir=\"ltr\" role=\"presentation\">ing<\/span> <span dir=\"ltr\" role=\"presentation\">patient to go to ED if not<\/span> <span dir=\"ltr\" role=\"presentation\">in clinic. Must<\/span> <span dir=\"ltr\" role=\"presentation\">call<\/span> <span dir=\"ltr\" role=\"presentation\">ED to provide history and clinical details.<\/span><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Initiation-Schedule.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-13976\" src=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Initiation-Schedule-300x120.jpg\" alt=\"Sample Clozapine Initiation Schedule\" width=\"300\" height=\"120\" srcset=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Initiation-Schedule-300x120.jpg 300w, https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Initiation-Schedule-768x308.jpg 768w, https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Initiation-Schedule-600x240.jpg 600w, https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Initiation-Schedule.jpg 839w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<h4><a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Metformin_protocol_7-31-19-1.pdf\" target=\"_blank\" rel=\"noopener\"><strong>NCCN Metformin Use in Antipsychotic Drug-Associated Weight Gain<\/strong><\/a><\/h4>\n<ul>\n<li><span id=\"page3R_mcid2\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">General c<\/span><span dir=\"ltr\" role=\"presentation\">onsiderations<\/span> <span dir=\"ltr\" role=\"presentation\">for weight interventions<\/span><span dir=\"ltr\" role=\"presentation\">.<\/span><\/span><\/li>\n<li><span id=\"page3R_mcid7\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">When to consider<\/span> <span dir=\"ltr\" role=\"presentation\">Metformin<\/span> <span dir=\"ltr\" role=\"presentation\">for weight.<\/span><\/span><\/li>\n<li><span id=\"page3R_mcid13\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Evid<\/span><span dir=\"ltr\" role=\"presentation\">ence to support<\/span> <span dir=\"ltr\" role=\"presentation\">M<\/span><span dir=\"ltr\" role=\"presentation\">etformin<\/span> <span dir=\"ltr\" role=\"presentation\">for<\/span> <span dir=\"ltr\" role=\"presentation\">weight<\/span> <span dir=\"ltr\" role=\"presentation\">control<\/span><span dir=\"ltr\" role=\"presentation\">.<\/span><\/span><\/li>\n<li><span id=\"page21R_mcid0\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Potential added<\/span> <span dir=\"ltr\" role=\"presentation\">benefits of metformin<\/span><\/span>.<\/li>\n<li><span id=\"page21R_mcid6\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Metformin Side Effects<\/span><\/span> and <span id=\"page21R_mcid21\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">(Relative) Contraindications<\/span> <span dir=\"ltr\" role=\"presentation\">to Metform<\/span><span dir=\"ltr\" role=\"presentation\">in<\/span><\/span>.<\/li>\n<li><span id=\"page25R_mcid0\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Pre<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">Metformin workup<\/span><\/span>, I<span id=\"page25R_mcid8\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">nitiating M<\/span><span dir=\"ltr\" role=\"presentation\">etformin<\/span><\/span> and Ongoing Monitoring<\/li>\n<\/ul>\n<h4><a href=\"https:\/\/www.newclozapinerems.com\/home\" target=\"_blank\" rel=\"noopener\"><strong>Become a Clozapine Prescriber, Pharmacist, or Registered Pharmacy<\/strong><\/a><\/h4>\n<ul>\n<li><a href=\"https:\/\/www.newclozapinerems.com\/Public\/home\/Prescriber\" target=\"_blank\" rel=\"noopener\">Clozapine Prescriber Certification and Registration<\/a><\/li>\n<li><a href=\"https:\/\/www.newclozapinerems.com\/Public\/home\/Pharmacy\" target=\"_blank\" rel=\"noopener\">Clozapine Pharmacy (and Pharmacist) Certification and Registration<\/a><\/li>\n<\/ul>\n<p>For questions or assistance with this process, please <a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/consultation-service\/\">consult the NCCN<\/a>. Please do <u>not<\/u> contact the NCCN for <a href=\"https:\/\/cpmgstorageproduction.blob.core.windows.net\/cpmg-public\/cpmg-faq-faqs%20v0_04%20clean.pdf?skoid=153f69fb-5a75-4401-8fda-28b1bd974fd0&amp;sktid=59fc620e-de8c-4745-abcc-18182d1bf20e&amp;skt=2022-11-08T18%3A27%3A01Z&amp;ske=2022-11-14T18%3A32%3A01Z&amp;sks=b&amp;skv=2020-04-08&amp;sv=2020-04-08&amp;st=2021-08-10T13%3A52%3A01Z&amp;se=2031-08-10T23%3A59%3A59Z&amp;sr=b&amp;sp=rc&amp;sig=0MQmIVrJKJ670yF0xWDTHPEDSAjxiRUInZRi6CnAPec%3D\" target=\"_blank\" rel=\"noopener\">technical difficulties<\/a> with the Clozapine REMS website.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NCCN Outpatient Clozapine Initiation Titration Schedule A sample titration schedule. Adjustments may be needed based on individual tolerability; we recommend a slower titration when there are greater than mild side effects. We also recommend consolidating to nighttime dosing in cases of excessive daytime sedation OR difficulty with optimal medication adherence. Target dose of 300 mg &hellip; <a href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/\" aria-label=\"Read more about Clozapine Toolkit\">Read more<\/a><\/p>\n","protected":false},"author":97082,"featured_media":0,"parent":11359,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-13972","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clozapine Toolkit - UNC Center for Excellence in Community Mental Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clozapine Toolkit - UNC Center for Excellence in Community Mental Health\" \/>\n<meta property=\"og:description\" content=\"NCCN Outpatient Clozapine Initiation Titration Schedule A sample titration schedule. Adjustments may be needed based on individual tolerability; we recommend a slower titration when there are greater than mild side effects. We also recommend consolidating to nighttime dosing in cases of excessive daytime sedation OR difficulty with optimal medication adherence. Target dose of 300 mg &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Center for Excellence in Community Mental Health\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-08T18:53:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-300x120.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/\",\"url\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/\",\"name\":\"Clozapine Toolkit - UNC Center for Excellence in Community Mental Health\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-300x120.jpg\",\"datePublished\":\"2022-03-22T14:51:06+00:00\",\"dateModified\":\"2022-11-08T18:53:19+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule.jpg\",\"width\":839,\"height\":336,\"caption\":\"Sample Clozapine Titration Schedule\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Education &amp; Training\",\"item\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"North Carolina Clozapine Network (NCCN)\",\"item\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Clozapine Toolkit\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/\",\"name\":\"UNC Center for Excellence in Community Mental Health\",\"description\":\"Department of Psychiatry\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/psych\/cecmh\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Clozapine Toolkit - UNC Center for Excellence in Community Mental Health","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/","og_locale":"en_US","og_type":"article","og_title":"Clozapine Toolkit - UNC Center for Excellence in Community Mental Health","og_description":"NCCN Outpatient Clozapine Initiation Titration Schedule A sample titration schedule. Adjustments may be needed based on individual tolerability; we recommend a slower titration when there are greater than mild side effects. We also recommend consolidating to nighttime dosing in cases of excessive daytime sedation OR difficulty with optimal medication adherence. Target dose of 300 mg &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/","og_site_name":"UNC Center for Excellence in Community Mental Health","article_modified_time":"2022-11-08T18:53:19+00:00","og_image":[{"url":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-300x120.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/","url":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/","name":"Clozapine Toolkit - UNC Center for Excellence in Community Mental Health","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule-300x120.jpg","datePublished":"2022-03-22T14:51:06+00:00","dateModified":"2022-11-08T18:53:19+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#primaryimage","url":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule.jpg","contentUrl":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-content\/uploads\/sites\/880\/2022\/03\/Titration-Schedule.jpg","width":839,"height":336,"caption":"Sample Clozapine Titration Schedule"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/clozapine-toolkit\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/psych\/cecmh\/"},{"@type":"ListItem","position":2,"name":"Education &amp; Training","item":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/"},{"@type":"ListItem","position":3,"name":"North Carolina Clozapine Network (NCCN)","item":"https:\/\/www.med.unc.edu\/psych\/cecmh\/education-and-training\/north-carolina-clozapine-network-nccn\/"},{"@type":"ListItem","position":4,"name":"Clozapine Toolkit"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/psych\/cecmh\/#website","url":"https:\/\/www.med.unc.edu\/psych\/cecmh\/","name":"UNC Center for Excellence in Community Mental Health","description":"Department of Psychiatry","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/psych\/cecmh\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/pages\/13972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/users\/97082"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/comments?post=13972"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/pages\/13972\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/pages\/11359"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/psych\/cecmh\/wp-json\/wp\/v2\/media?parent=13972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}