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Flavio Frohlich

Associate Professor of Psychiatry, Cell Biology & Physiology, and Biomedical Engineering


Associate Professor

Associate Vice Chair of Research

Department of Psychiatry

Director, Carolina Center for Neurostimulation


UNC Hospitals – Chapel Hill

Education and Training:

International Diploma, Electrical and Electronic Engineering, Imperial College, London, United Kingdom
, Information Technology and Electrical Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland
PhD., Computational Neurobiology, University of California, San Diego & The Salk Institute for Biological Studies
Postdoctoral Fellowship, Neurobiology, Yale University

Summary Statement:

The laboratory of Dr. Frohlich studies cortical state dynamics and develops non-invasive brain stimulation approaches to treat neuropsychiatric illnesses such as schizophrenia, autism, and depression that are caused by pathological network dynamics. Dr. Frohlich employs a multidisciplinary approach that combines large-scale computer simulations of cortical networks, in vitro multi electrode and patch-clamp electrophysiology, parallel extracellular electrophysiology in awake and anesthetized ferrets, and electroencephalography combined with transcranial current stimulation in humans. The integration of these methods allow for the discovery of the fundamental guiding principles of cortical network dynamics and the development of targeted, individualized brain-stimulation based on control engineering for the treatment of psychiatric patient populations for which there exists little help from currently approved medications. Recent discoveries in the lab include (1) the mechanism of action of transcranial Alternating Current stimulation (tACs), (2) a novel brain stimulation paradigm in humans to enhance the endogenous antagonism of slow and fast brain rhythms, (3) the differential role of cholinergic and adrenergic signaling defining cortical activity states, and (4) the role of anesthesia on cortical state dynamics and sensory processing.

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Flavio Frohlich