Why? Eating disorders (anorexia nervosa, bulimia nervosa, binge-eating disorder), life-disrupting and have the highest mortality rate of any psychiatric illness—but they are grossly underfunded relative to the disability they cause. Our work has revolutionized the field by demonstrating a strong genetic component to anorexia nervosa. But, we have only just begun.

What? EDGI is an ambitious global effort to rapidly and efficiently ample, genotype, and biobank 100K samples for genome-wide association studies (GWAS) of eating disorders. UNC and collaborators aim to contribute at least 25K to the effort.

Who? UNC’s Dr. Cynthia Bulik is leading the effort and will be joined by our collaborators in Sweden, Denmark, New Zealand, and Australia.

How? We are part of the Psychiatric Genomics Consortium (PGC)—the largest most successful consortium in the history of psychiatry. EDGI will deliver “actionable” findings and genomic results that 1) reveal fundamental biology, 2) inform clinical practice, and 3) inform new therapeutic targets.

When? EDGI is a five year project to collect samples, genotype, analyze, and disseminate. Our biobanked samples and data repository will form a sustainable resource for follow-on investigations by ourselves and other qualified researchers in the field.

Outcome. EDGI will accelerate genomic discovery for all three eating disorders. Our results will be mined for relevance for improved therapeutics and impact on psychiatric practice within a precision medicine framework.

Donate and Join the EDGI Community. We are gathering funds to support EDGI which is a 10 million dollar enterprise. We encourage you to give a gift and to tell others about this initiative. Together, we can crack the genetic code of eating disorders.