{"id":17900,"date":"2025-11-17T13:36:30","date_gmt":"2025-11-17T18:36:30","guid":{"rendered":"https:\/\/www.med.unc.edu\/psych\/?page_id=17900"},"modified":"2026-03-12T10:38:38","modified_gmt":"2026-03-12T14:38:38","slug":"bridge-laboratory","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/psych\/research\/psychiatry-department-research-programs\/bridge-laboratory\/","title":{"rendered":"BRIDGE Laboratory"},"content":{"rendered":"<figure id=\"attachment_18188\" class=\"thumbnail wp-caption alignright\" style=\"width: 310px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-18188 size-medium\" src=\"https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2025\/11\/Pat-Smith_HPDP-office-300x238.jpg\" alt=\"Patrick Smith\" width=\"300\" height=\"238\" srcset=\"https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2025\/11\/Pat-Smith_HPDP-office-300x238.jpg 300w, https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2025\/11\/Pat-Smith_HPDP-office-1024x812.jpg 1024w, https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2025\/11\/Pat-Smith_HPDP-office-768x609.jpg 768w, https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2025\/11\/Pat-Smith_HPDP-office-1536x1218.jpg 1536w, https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2025\/11\/Pat-Smith_HPDP-office-2048x1624.jpg 2048w, https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2025\/11\/Pat-Smith_HPDP-office-600x476.jpg 600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"caption wp-caption-text\">Dr. Patrick J. Smith is a clinical psychologist and biostatistician with expertise in behavioral medicine and neuropsychology. He also directs the BRIDGE Laboratory.<\/figcaption><\/figure>\n<h2><strong>BRIDGE: <u>B<\/u>iobehavioral <u>R<\/u>esilience <u>I<\/u>nterventions using <u>D<\/u>iet and <u>G<\/u>raduated <u>E<\/u>xercise<\/strong><\/h2>\n<p>The <strong>BRIDGE Laboratory<\/strong> has ready access to phlebotomy and blood sample processing facilities, laboratory space dedicated to neuropsychological testing, source materials for neuropsychological assessments and normative measures, biobehavioral assessment materials (including actigraphy, physical frailty, and ambulatory cognition assessments) and physical space for behavioral intervention delivery.<\/p>\n<p>Dr. Smith is an Associate Professor of Psychiatry and Neurology at UNC-CH, where he began his current appointment in 2022. Prior to this, he had spent nearly 20 years working and training at Duke University and DUMC, beginning as a research assistant in 2003 and then PhD graduate student in Clinical Health Psychology in 2005. After obtaining his PhD at Duke in 2010, he completed dual-postdoctoral trainings in behavioral medicine and clinical neuropsychology at DUMC. He also completed an MPH in biostatistics at UNC-CH in parallel.<\/p>\n<p>His research is focused on using biobehavioral interventions to improve cognitive function and mental health outcomes among adults with chronic medical conditions, with a particular focus on targeting cardiometabolic treatment mechanisms. He has been continuously funded by the NIH over the past 15 years, including from the NHLBI and NIA, as well as from foundation and industry sponsors. He was previously a standing member of one of the NIH\u2019s primary behavioral medicine study sections: Biobehavioral Medicine and Health Outcomes (BMHO). He also serves as the co-lead for the UNC clinical core on the Duke-UNC Alzheimer\u2019s Disease Research Center and is the sole UNC neuropsychologist.<\/p>\n<a class=\"btn btn-primary btn-lg  oscitas-bootstrap-container\" target=\"_blank\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Smith+PJ&amp;sort=date\">Publications<\/a>\n<hr \/>\n<h3><strong>Current Studies<\/strong><\/h3>\n<p>Dr. Smith&#8217;s current projects include the use of time-restricted eating to improve cognitive functioning, remotely-delivered telehealth interventions to improve physical frailty in solid organ transplant candidates, the use of Acceptance and Commitment Therapy (ACT) telehealth interventions among individuals with chronic medical conditions, precision approaches to enhance prediction of dementia, and examining cardiovascular mechanisms of improved sleep quality using Cognitive Behavioral Therapy for Insomnia (CBT-I).<\/p>\n<p><strong>Affiliated Collabroators<\/strong><\/p>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-3 col-md-3 col-xs-12 col-sm-3 oscitas-bootstrap-container\">\n<p><a href=\"https:\/\/exss.unc.edu\/faculty-staff\/erik-hanson\/\" target=\"_blank\" rel=\"noopener\" data-outlook-id=\"d171b8a9-a8ac-4fb8-832e-b13d9621c74d\">Erik Hanson<\/a> (UNC)<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/psych\/people\/lisa-kanser-psy-d\/\" target=\"_blank\" rel=\"noopener\" data-outlook-id=\"ebd42a1f-6f52-4dda-bc49-3122fa6ef031\">Lisa Kanser<\/a> (UNC)<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/psych\/people\/zev-nakamura-md\/\" target=\"_blank\" rel=\"noopener\" data-outlook-id=\"0d44697c-4946-4063-a7a2-610c46116f89\">Zev Nakamura<\/a> (UNC)<\/p>\n<\/div>\n<div class=\"col-lg-3 col-md-3 col-xs-12 col-sm-3 oscitas-bootstrap-container\">\n<p><a href=\"https:\/\/dmpi.duke.edu\/profile\/kim-marie-huffman\" target=\"_blank\" rel=\"noopener\" data-outlook-id=\"0a572c88-4e26-4339-b978-abf5a8da4ac5\">Kim Huffman<\/a> (Duke)<\/p>\n<p><a href=\"https:\/\/medicine.duke.edu\/profile\/heather-elizabeth-whitson\" target=\"_blank\" rel=\"noopener\" data-outlook-id=\"77723032-7f7d-4882-a110-06284068f2b2\">Heather Whitson<\/a> (Duke)<\/p>\n<\/div>\n<div class=\"col-lg-6 col-md-6 col-xs-12 col-sm-6 oscitas-bootstrap-container\">\n<p><a href=\"https:\/\/www.jefferson.edu\/academics\/colleges-schools-institutes\/skmc\/departments\/psychiatry\/faculty\/ohayer.html\" target=\"_blank\" rel=\"noopener\" data-outlook-id=\"1618c843-f8b9-4d01-80d9-a9ed279556ee\">Virginia O\u2019Hayer<\/a> (Thomas Jefferson University)<\/p>\n<p><a href=\"https:\/\/singergroup.ucsf.edu\/content\/jonathan-singer-md\" target=\"_blank\" rel=\"noopener\" data-outlook-id=\"63bc9ecc-4736-4fd4-83f0-887fb4ac82ea\">Jonathan Singer<\/a> (UCSF)<\/p>\n<\/div><\/div>\n<div role=\"tablist\" class=\"panel-group accordion-blue oscitas-bootstrap-container\" id=\"unc-accordion-0\">\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-0\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-0\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-0\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-0\">\n                TEMPO Study            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-0\" class=\"panel-collapse collapse out oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\"> The focus of this study is the use of time restricted eating (TRE) to improve metabolic and cognitive functioning among older adults with mild cognitive impairment (MCI). Our goal is to examine whether individuals with MCI can engage and sustain engagement in a 16:2 intermittent fasting protocol, the preliminary effects of TRE on metabolism, inflammation, and cognitive function, and the associations between changes in metabolic function, inflammation, and cognitive function.<\/p>\n<p><strong>Status:<\/strong> Enrollment Completed (analysis phase)<\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-1\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-1\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-1\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-1\">\n                XFIT Study            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-1\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">The focus of this study is the use of a telehealth, exercise-based, prehabilitation intervention to improve physical activity and physical frailty measures among individuals undergoing lung transplantation. This trial, conducted in collaboration with Dr. Jon Singer, examines whether we can develop a remotely delivered behavioral intervention to improve physical frailty as a \u2018prehabilitation\u2019 intervention for those that cannot access standard pulmonary rehabilitation.<\/p>\n<p><strong>Status:<\/strong> Ongoing <\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-2\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-2\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-2\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-2\">\n                CBT-I for Insomnia Study            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-2\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\"> Dr. Smith is a collaborator on several trials examining the cardiovascular mechanisms of a Cognitive Behavioral Therapy for Insomnia (CBT-I) intervention among individuals with risk factors for cardiovascular disease. These trials, conducted in collaboration with Drs. Andrew Sherwood and Jean Beckham, attempt to examine how enhancing sleep quality may reduce cardiovascular risk.<\/p>\n<p><strong>Status:<\/strong> Enrollment Completed (analysis phase)<\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-3\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-3\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-3\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-3\">\n                ACT for Chronic Health Conditions Study            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-3\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\"> Dr. Smith is an active collaborator with Dr. Virginia O\u2019Hayer and other colleagues examining the use of telehealth delivered Acceptance and Commitment Therapy (ACT) to improve coping with chronic medical conditions. Recent trials, including ACT with CF and ACT with NMOSD, have demonstrated that brief telehealth interventions can improve psychological flexibility and psychological functioning among individuals with chronic medical conditions and that these improvements appear to be sustained over subsequent months following intervention completion.<\/p>\n<p><strong>Status:<\/strong> Ongoing <\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-4\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-4\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-4\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-4\">\n                Duke-UNC ADRC            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-4\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">Dr. Smith is one of two neuropsychologists on the <a href=\"https:\/\/dukeuncadrc.org\/\" target=\"_blank\" rel=\"noopener\">Duke-UNC ADRC<\/a>, serving as a member of the <a href=\"https:\/\/dukeuncadrc.org\/core\/clinical-core\" data-outlook-id=\"6fed057e-e2c0-4886-aac7-82f1894cbab2\">UNC Clinical Core<\/a>. The Duke-UNC ADRC is focused on identifying modifiable risk factors for Alzheimer\u2019s Disease and Related Dementias (ADRD) that can be treated in order to reduce risk of ADRD later in life. Dr. Smith has led several of the initial publications for the ADRC, focusing on the role of physical frailty and sensory functions as they relate to cognitive function and cerebrospinal fluid ADRD biomarkers.<\/p>\n<p><strong>Status:<\/strong> Ongoing<\/div>\n\n    <\/div>\n        \n<\/div>\n<\/div>\n<hr \/>\n<script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\nvar gform;gform||(document.addEventListener(\"gform_main_scripts_loaded\",function(){gform.scriptsLoaded=!0}),document.addEventListener(\"gform\/theme\/scripts_loaded\",function(){gform.themeScriptsLoaded=!0}),window.addEventListener(\"DOMContentLoaded\",function(){gform.domLoaded=!0}),gform={domLoaded:!1,scriptsLoaded:!1,themeScriptsLoaded:!1,isFormEditor:()=>\"function\"==typeof InitializeEditor,callIfLoaded:function(o){return!(!gform.domLoaded||!gform.scriptsLoaded||!gform.themeScriptsLoaded&&!gform.isFormEditor()||(gform.isFormEditor()&&console.warn(\"The use of gform.initializeOnLoaded() is deprecated in the form editor context and will be removed in Gravity Forms 3.1.\"),o(),0))},initializeOnLoaded:function(o){gform.callIfLoaded(o)||(document.addEventListener(\"gform_main_scripts_loaded\",()=>{gform.scriptsLoaded=!0,gform.callIfLoaded(o)}),document.addEventListener(\"gform\/theme\/scripts_loaded\",()=>{gform.themeScriptsLoaded=!0,gform.callIfLoaded(o)}),window.addEventListener(\"DOMContentLoaded\",()=>{gform.domLoaded=!0,gform.callIfLoaded(o)}))},hooks:{action:{},filter:{}},addAction:function(o,r,e,t){gform.addHook(\"action\",o,r,e,t)},addFilter:function(o,r,e,t){gform.addHook(\"filter\",o,r,e,t)},doAction:function(o){gform.doHook(\"action\",o,arguments)},applyFilters:function(o){return gform.doHook(\"filter\",o,arguments)},removeAction:function(o,r){gform.removeHook(\"action\",o,r)},removeFilter:function(o,r,e){gform.removeHook(\"filter\",o,r,e)},addHook:function(o,r,e,t,n){null==gform.hooks[o][r]&&(gform.hooks[o][r]=[]);var d=gform.hooks[o][r];null==n&&(n=r+\"_\"+d.length),gform.hooks[o][r].push({tag:n,callable:e,priority:t=null==t?10:t})},doHook:function(r,o,e){var t;if(e=Array.prototype.slice.call(e,1),null!=gform.hooks[r][o]&&((o=gform.hooks[r][o]).sort(function(o,r){return o.priority-r.priority}),o.forEach(function(o){\"function\"!=typeof(t=o.callable)&&(t=window[t]),\"action\"==r?t.apply(null,e):e[0]=t.apply(null,e)})),\"filter\"==r)return e[0]},removeHook:function(o,r,t,n){var e;null!=gform.hooks[o][r]&&(e=(e=gform.hooks[o][r]).filter(function(o,r,e){return!!(null!=n&&n!=o.tag||null!=t&&t!=o.priority)}),gform.hooks[o][r]=e)}});\n\/* ]]> *\/\n<\/script>\n\n                <div class='gf_browser_gecko gform_wrapper gravity-theme gform-theme--no-framework' data-form-theme='gravity-theme' data-form-index='0' id='gform_wrapper_5' >\n                        <div class='gform_heading'>\n                            <h2 class=\"gform_title\">Contact BRIDGE Lab<\/h2>\n                            <p class='gform_description'><\/p>\n\t\t\t\t\t\t\t<p class='gform_required_legend'>&quot;<span class=\"gfield_required gfield_required_asterisk\">*<\/span>&quot; 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