{"id":7099,"date":"2020-07-17T09:29:17","date_gmt":"2020-07-17T13:29:17","guid":{"rendered":"https:\/\/www.med.unc.edu\/psych\/?page_id=7099"},"modified":"2021-10-06T09:59:36","modified_gmt":"2021-10-06T13:59:36","slug":"recent-publications","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/psych\/research\/recent-publications\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"\n<ul class=\"media alt-media\">\n        \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41735536\/\" rel=\"bookmark\" title=\"Orbitofrontal cortex drives predictive filtering of sensory responses.\">\n                                    Orbitofrontal cortex drives predictive filtering of sensory responses.<\/a>\n                                <\/h4>                            <p>Reduced sensory habituation\u2014the brain\u2019s ability to filter out repetitive, irrelevant stimuli\u2014 is commonly found in neurodevelopmental disorders. We found that predictive signals from the orbitofrontal cortex to the primary auditory cortex actively drive this process, providing insights into the neural basis of impaired habituation.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41530554\/\" rel=\"bookmark\" title=\"Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression\">\n                                    Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression<\/a>\n                                <\/h4>                            <p>This review examines factors influencing the recurrence of depressive episodes following remission in LLD, focusing on cognitive, behavioral, social, environmental, and neuroimaging influences. It further proposes possible mechanisms contributing to recurrence, including physiological and behavioral responses to stressors, the influence of Alzheimer&#8217;s disease neuropathology, and conceptualizing repeat depressive episodes within the accelerated aging hypothesis of &hellip; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41530554\/\" aria-label=\"Read more about Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41218355\/\" rel=\"bookmark\" title=\"Pilot randomized controlled trial of Bolster, an mHealth intervention for caregivers to young people with early psychosis.\">\n                                    Pilot randomized controlled trial of Bolster, an mHealth intervention for caregivers to young people with early psychosis.<\/a>\n                                <\/h4>                            <p>In this pilot randomized controlled trial, our team evaluated the feasibility and preliminary effectiveness of a mobile health (mHealth) intervention for caregivers to youth at risk for psychosis, called Bolster. Results suggested that Bolster was feasible to deliver, acceptable to this population, and demonstrated promising effectiveness in improving family communication, reducing caregiver distress, and increasing &hellip; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41218355\/\" aria-label=\"Read more about Pilot randomized controlled trial of Bolster, an mHealth intervention for caregivers to young people with early psychosis.\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40912312\/\" rel=\"bookmark\" title=\"Characterizing the spectrum of distress symptoms in midlife women with perimenopausal depression\">\n                                    Characterizing the spectrum of distress symptoms in midlife women with perimenopausal depression<\/a>\n                                <\/h4>                            <p>This study compared late-perimenopausal women with and without perimenopausal-onset major depressive disorder (PO-MDD) to examine patterns of depression, anxiety, temperament, and menopausal symptoms. Women with PO-MDD showed significantly higher levels of irritability, anxiety, negative temperament, and overall menopausal distress, suggesting that screening for anxiety and related symptoms is important when assessing depression during perimenopause.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41678699\/\" rel=\"bookmark\" title=\"Seven Desiderata for Ethical Frameworks for AI Mental Health Agents\">\n                                    Seven Desiderata for Ethical Frameworks for AI Mental Health Agents<\/a>\n                                <\/h4>                            <p>We offer 7 observations regarding use of AI chatbots for mental health and emotional support and 7 desiderata that any ethical framework for monitoring and regulating such chatbots should meet. We then illustrate how these desiderata help in assessing frameworks by using them to assess a recent paper by Serife Tekin and Megan Delehanty on &hellip; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41678699\/\" aria-label=\"Read more about Seven Desiderata for Ethical Frameworks for AI Mental Health Agents\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41711655\/\" rel=\"bookmark\" title=\"Associations Between Neurobehavioral Symptoms During Breast Cancer Chemotherapy and Patient-Reported Cognitive Impairment 3 or More Years After Chemotherapy\">\n                                    Associations Between Neurobehavioral Symptoms During Breast Cancer Chemotherapy and Patient-Reported Cognitive Impairment 3 or More Years After Chemotherapy<\/a>\n                                <\/h4>                            <p>Many women treated for early-stage breast cancer report ongoing problems with memory and thinking years after chemotherapy. In this study, nearly 40% of survivors reported long-term cognitive concerns, and those who experienced depression, anxiety, or fatigue during chemotherapy were significantly more likely to have these difficulties years later\u2014highlighting the importance of monitoring and addressing these &hellip; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41711655\/\" aria-label=\"Read more about Associations Between Neurobehavioral Symptoms During Breast Cancer Chemotherapy and Patient-Reported Cognitive Impairment 3 or More Years After Chemotherapy\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41620430\/\" rel=\"bookmark\" title=\"Brexanolone infusion produces sustained anti-inflammatory and neurotrophic effects in patients with postpartum depression that predict symptom improvement\">\n                                    Brexanolone infusion produces sustained anti-inflammatory and neurotrophic effects in patients with postpartum depression that predict symptom improvement<\/a>\n                                <\/h4>                            <p>Postpartum depression (PPD) is linked to neuroimmune dysregulation. Brexanolone, an intravenous formulation of the neurosteroid allopregnanolone and the first FDA-approved treatment for PPD, produces rapid and sustained antidepressant effects. However, its long-term mechanisms of action remain unclear. This study evaluated brexanolone\u2019s prolonged impact on two groups of biomarkers in whole blood: inflammatory mediators and growth\/differentiation\/neurotrophic &hellip; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41620430\/\" aria-label=\"Read more about Brexanolone infusion produces sustained anti-inflammatory and neurotrophic effects in patients with postpartum depression that predict symptom improvement\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                            <a class=\"pull-left\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41181354\/\">\n                            <div class=\"thumbnail\">\n                                <img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2026\/03\/Research-Posts-5-150x150.png\" class=\"attachment-post_thumbnail size-post_thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2026\/03\/Research-Posts-5-150x150.png 150w, https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2026\/03\/Research-Posts-5-600x600.png 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\">                            <\/div>\n                        <\/a>\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41181354\/\" rel=\"bookmark\" title=\"Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma\">\n                                    Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma<\/a>\n                                <\/h4>                            <p>Posttraumatic stress disorder (PTSD) can develop after experiencing or witnessing a traumatic event, such as an accident or assault. Symptoms can include flashbacks, anxiety, and emotional distress, which significantly impact daily life. This study explores how changes in brain activity after trauma can predict future symptoms of posttraumatic stress (PTS). We examined data from 275 &hellip; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41181354\/\" aria-label=\"Read more about Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41422952\/\" rel=\"bookmark\" title=\"Novel methods for detecting hormone sensitive affective dysregulation in regularly cycling women: A proof-of-concept study\">\n                                    Novel methods for detecting hormone sensitive affective dysregulation in regularly cycling women: A proof-of-concept study<\/a>\n                                <\/h4>                            <p>This proof-of-concept study examined whether simpler, less invasive methods could identify women who are sensitive to normal fluctuations in ovarian hormones, a factor believed to contribute to mood disorders such as perinatal depression. Researchers tested a shortened seven-day hormone challenge and prospective menstrual cycle mood tracking, finding that these approaches may offer practical alternatives to &hellip; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41422952\/\" aria-label=\"Read more about Novel methods for detecting hormone sensitive affective dysregulation in regularly cycling women: A proof-of-concept study\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                \n                            <li class=\"media-listitem\">\n                                            <a class=\"pull-left\" href=\"https:\/\/www.med.unc.edu\/psych\/translational-team-science-tts-award-congratulations-dr-wu\/\">\n                            <div class=\"thumbnail\">\n                                <img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2018\/10\/Guorong-Wu-150x150.jpg\" class=\"attachment-post_thumbnail size-post_thumbnail wp-post-image\" alt=\"photo of guorong wu\" srcset=\"https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2018\/10\/Guorong-Wu-150x150.jpg 150w, https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2018\/10\/Guorong-Wu-600x600.jpg 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\">                            <\/div>\n                        <\/a>\n                                        <div class=\"media-body\">\n                        <div class=\"caption\">\n                            <h4 class=\"media-heading\" data-shouldbe=\"h4\">                                <a href=\"https:\/\/www.med.unc.edu\/psych\/translational-team-science-tts-award-congratulations-dr-wu\/\" rel=\"bookmark\" title=\"Translational Team Science (TTS) Award: Congratulations, Dr. Wu!\">\n                                    Translational Team Science (TTS) Award: Congratulations, Dr. Wu!<\/a>\n                                <\/h4>                            <p>Dr. Guorong Wu was part of an interdisciplinary team that was just awarded a SOM Team Science grant for the project \u201cEnergy allocation between brain and periphery in children with and without obesity.\u201d Pediatric obesity is increasingly viewed as a brain-related condition, as higher BMI in children is linked to structural and functional brain differences, &hellip; <a href=\"https:\/\/www.med.unc.edu\/psych\/translational-team-science-tts-award-congratulations-dr-wu\/\" aria-label=\"Read more about Translational Team Science (TTS) Award: Congratulations, Dr. Wu!\">Read more<\/a><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                                <\/ul>\n    \n","protected":false},"excerpt":{"rendered":"","protected":false},"author":103208,"featured_media":0,"parent":2275,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-7099","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Recent Publications | Department of Psychiatry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/psych\/research\/recent-publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recent Publications 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